Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888503604> ?p ?o ?g. }
- W1888503604 endingPage "1600" @default.
- W1888503604 startingPage "1593" @default.
- W1888503604 abstract "A major focus of studies that center on regeneration of the periodontium is to determine the efficacy of the use of polypeptide growth factors. Platelet-derived growth factor has been reported to be a possible agent for clinical use. PDGF has various isoforms. Therefore, we decided to study the mitogenic and chemotactic responses of human periodontal ligament (PDL) cells to recombinant human PDGF-AB, AA, and BB. Addition of each isoform of PDGF to in vitro mitogenesis assays induced PDL cell proliferation in a dose-dependent manner. The maximum mitogenic effect was evident at the concentration of 100 ng/mL. In these assays, PDGF-BB was found to be the most potent mitogen. PDGF-AB elicited an intermediate response, and PDGF-AA was the least effective. The results of chemotaxis assays closely parallel those of the mitogenesis assays. PDGF-BB exhibited the most potent chemotactic effect. The maximal effect was observed at 10 ng/mL. The findings of these experiments indicate that PDGF-BB is more effective than the other isoforms in promoting mitogenesis and chemotaxis of PDL cells in vitro, and may therefore be a suitable ethical pharmaceutical for use in periodontal regeneration procedures." @default.
- W1888503604 created "2016-06-24" @default.
- W1888503604 creator A5006017962 @default.
- W1888503604 creator A5028120017 @default.
- W1888503604 creator A5060441883 @default.
- W1888503604 creator A5080351529 @default.
- W1888503604 creator A5082657818 @default.
- W1888503604 creator A5086340755 @default.
- W1888503604 date "1994-10-01" @default.
- W1888503604 modified "2023-10-11" @default.
- W1888503604 title "Mitogenic and Chemotactic Responses of Human Periodontal Ligament Cells to the Different Isoforms of Platelet-derived Growth Factor" @default.
- W1888503604 cites W120809866 @default.
- W1888503604 cites W1493414055 @default.
- W1888503604 cites W1510419597 @default.
- W1888503604 cites W1522048024 @default.
- W1888503604 cites W1570617743 @default.
- W1888503604 cites W1856298654 @default.
- W1888503604 cites W1885472586 @default.
- W1888503604 cites W1963873340 @default.
- W1888503604 cites W1973631902 @default.
- W1888503604 cites W1974154033 @default.
- W1888503604 cites W1980322182 @default.
- W1888503604 cites W1983041452 @default.
- W1888503604 cites W1998155351 @default.
- W1888503604 cites W2020457061 @default.
- W1888503604 cites W2038595692 @default.
- W1888503604 cites W2039411384 @default.
- W1888503604 cites W2039844297 @default.
- W1888503604 cites W2039981641 @default.
- W1888503604 cites W2040470809 @default.
- W1888503604 cites W2045389909 @default.
- W1888503604 cites W2047129716 @default.
- W1888503604 cites W2048478219 @default.
- W1888503604 cites W2049596719 @default.
- W1888503604 cites W2051331754 @default.
- W1888503604 cites W2053280162 @default.
- W1888503604 cites W2056557043 @default.
- W1888503604 cites W2059722792 @default.
- W1888503604 cites W2060293093 @default.
- W1888503604 cites W2066348646 @default.
- W1888503604 cites W2069100650 @default.
- W1888503604 cites W2072733843 @default.
- W1888503604 cites W2081527835 @default.
- W1888503604 cites W2086600284 @default.
- W1888503604 cites W2090925626 @default.
- W1888503604 cites W2091619620 @default.
- W1888503604 cites W2094891357 @default.
- W1888503604 cites W2101649677 @default.
- W1888503604 cites W2109381162 @default.
- W1888503604 cites W2116736324 @default.
- W1888503604 cites W2148371225 @default.
- W1888503604 cites W2154912685 @default.
- W1888503604 cites W2156905839 @default.
- W1888503604 cites W2166497857 @default.
- W1888503604 cites W2270571149 @default.
- W1888503604 cites W2292523598 @default.
- W1888503604 cites W2339357198 @default.
- W1888503604 cites W2366627350 @default.
- W1888503604 cites W2473765679 @default.
- W1888503604 cites W3023260993 @default.
- W1888503604 cites W3025750271 @default.
- W1888503604 cites W41707389 @default.
- W1888503604 cites W4235745237 @default.
- W1888503604 cites W4254966109 @default.
- W1888503604 cites W72404892 @default.
- W1888503604 doi "https://doi.org/10.1177/00220345940730100301" @default.
- W1888503604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7929973" @default.
- W1888503604 hasPublicationYear "1994" @default.
- W1888503604 type Work @default.
- W1888503604 sameAs 1888503604 @default.
- W1888503604 citedByCount "78" @default.
- W1888503604 countsByYear W18885036042012 @default.
- W1888503604 countsByYear W18885036042013 @default.
- W1888503604 countsByYear W18885036042014 @default.
- W1888503604 countsByYear W18885036042015 @default.
- W1888503604 countsByYear W18885036042016 @default.
- W1888503604 countsByYear W18885036042017 @default.
- W1888503604 countsByYear W18885036042018 @default.
- W1888503604 countsByYear W18885036042019 @default.
- W1888503604 countsByYear W18885036042020 @default.
- W1888503604 countsByYear W18885036042021 @default.
- W1888503604 countsByYear W18885036042022 @default.
- W1888503604 countsByYear W18885036042023 @default.
- W1888503604 crossrefType "journal-article" @default.
- W1888503604 hasAuthorship W1888503604A5006017962 @default.
- W1888503604 hasAuthorship W1888503604A5028120017 @default.
- W1888503604 hasAuthorship W1888503604A5060441883 @default.
- W1888503604 hasAuthorship W1888503604A5080351529 @default.
- W1888503604 hasAuthorship W1888503604A5082657818 @default.
- W1888503604 hasAuthorship W1888503604A5086340755 @default.
- W1888503604 hasConcept C104317684 @default.
- W1888503604 hasConcept C126322002 @default.
- W1888503604 hasConcept C153911025 @default.
- W1888503604 hasConcept C170493617 @default.
- W1888503604 hasConcept C171056886 @default.
- W1888503604 hasConcept C180361614 @default.
- W1888503604 hasConcept C185592680 @default.
- W1888503604 hasConcept C199343813 @default.