FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888513525> ?p ?o ?g. }

• W1888513525 endingPage "52" @default.
• W1888513525 startingPage "41" @default.
• W1888513525 abstract "The knowledge of protein-ligand binding sites is vital prerequisite for any structure-based virtual screening campaign. If no prior knowledge about binding sites is available, the ligand-binding site prediction methods are the only way to obtain the necessary information. Here we introduce P2RANK, a novel machine learning-based method for prediction of ligand binding sites from protein structure. P2RANK uses Random Forests learner to infer ligandability of local chemical neighborhoods near the protein surface which are represented by specific near-surface points and described by aggregating physico-chemical features projected on those points from neighboring protein atoms. The points with high predicted ligandability are clustered and ranked to obtain the resulting list of binding site predictions. The new method was compared with a state-of-the-art binding site prediction method Fpocket on three representative datasets. The results show that P2RANK outperforms Fpocket by 10 to 20 % points on all the datasets. Moreover, since P2RANK does not rely on any external software for computation of various complex features, such as sequence conservation scores or binding energies, it represents an ideal tool for inclusion into future structural bioinformatics pipelines." @default.
• W1888513525 created "2016-06-24" @default.
• W1888513525 creator A5049617942 @default.
• W1888513525 creator A5090048636 @default.
• W1888513525 date "2015-01-01" @default.
• W1888513525 modified "2023-10-16" @default.
• W1888513525 title "P2RANK: Knowledge-Based Ligand Binding Site Prediction Using Aggregated Local Features" @default.
• W1888513525 cites W1553149001 @default.
• W1888513525 cites W1571577887 @default.
• W1888513525 cites W1974732433 @default.
• W1888513525 cites W1975304761 @default.
• W1888513525 cites W1979414133 @default.
• W1888513525 cites W1982885147 @default.
• W1888513525 cites W1983194490 @default.
• W1888513525 cites W1985372952 @default.
• W1888513525 cites W1988195734 @default.
• W1888513525 cites W1991445257 @default.
• W1888513525 cites W1997655258 @default.
• W1888513525 cites W2004175162 @default.
• W1888513525 cites W2019951137 @default.
• W1888513525 cites W2021170902 @default.
• W1888513525 cites W2023170820 @default.
• W1888513525 cites W2024631466 @default.
• W1888513525 cites W2031194866 @default.
• W1888513525 cites W2053658804 @default.
• W1888513525 cites W2058463742 @default.
• W1888513525 cites W2060886672 @default.
• W1888513525 cites W2065232574 @default.
• W1888513525 cites W2066143642 @default.
• W1888513525 cites W2078176948 @default.
• W1888513525 cites W2081201773 @default.
• W1888513525 cites W2088638514 @default.
• W1888513525 cites W2096236743 @default.
• W1888513525 cites W2112109058 @default.
• W1888513525 cites W2123440974 @default.
• W1888513525 cites W2123578540 @default.
• W1888513525 cites W2128402268 @default.
• W1888513525 cites W2132395520 @default.
• W1888513525 cites W2138104170 @default.
• W1888513525 cites W2140407975 @default.
• W1888513525 cites W2144258433 @default.
• W1888513525 cites W2148797284 @default.
• W1888513525 cites W2149095014 @default.
• W1888513525 cites W2149434585 @default.
• W1888513525 cites W2153613893 @default.
• W1888513525 cites W2160544139 @default.
• W1888513525 cites W2164088236 @default.
• W1888513525 cites W2319117079 @default.
• W1888513525 cites W2911964244 @default.
• W1888513525 doi "https://doi.org/10.1007/978-3-319-21233-3_4" @default.
• W1888513525 hasPublicationYear "2015" @default.
• W1888513525 type Work @default.
• W1888513525 sameAs 1888513525 @default.
• W1888513525 citedByCount "5" @default.
• W1888513525 countsByYear W18885135252017 @default.
• W1888513525 countsByYear W18885135252018 @default.
• W1888513525 countsByYear W18885135252020 @default.
• W1888513525 countsByYear W18885135252022 @default.
• W1888513525 countsByYear W18885135252023 @default.
• W1888513525 crossrefType "book-chapter" @default.
• W1888513525 hasAuthorship W1888513525A5049617942 @default.
• W1888513525 hasAuthorship W1888513525A5090048636 @default.
• W1888513525 hasConcept C103697762 @default.
• W1888513525 hasConcept C107824862 @default.
• W1888513525 hasConcept C119857082 @default.
• W1888513525 hasConcept C124101348 @default.
• W1888513525 hasConcept C154945302 @default.
• W1888513525 hasConcept C169258074 @default.
• W1888513525 hasConcept C185592680 @default.
• W1888513525 hasConcept C41008148 @default.
• W1888513525 hasConcept C55493867 @default.
• W1888513525 hasConcept C60644358 @default.
• W1888513525 hasConcept C74187038 @default.
• W1888513525 hasConcept C86803240 @default.
• W1888513525 hasConceptScore W1888513525C103697762 @default.
• W1888513525 hasConceptScore W1888513525C107824862 @default.
• W1888513525 hasConceptScore W1888513525C119857082 @default.
• W1888513525 hasConceptScore W1888513525C124101348 @default.
• W1888513525 hasConceptScore W1888513525C154945302 @default.
• W1888513525 hasConceptScore W1888513525C169258074 @default.
• W1888513525 hasConceptScore W1888513525C185592680 @default.
• W1888513525 hasConceptScore W1888513525C41008148 @default.
• W1888513525 hasConceptScore W1888513525C55493867 @default.
• W1888513525 hasConceptScore W1888513525C60644358 @default.
• W1888513525 hasConceptScore W1888513525C74187038 @default.
• W1888513525 hasConceptScore W1888513525C86803240 @default.
• W1888513525 hasLocation W18885135251 @default.
• W1888513525 hasOpenAccess W1888513525 @default.
• W1888513525 hasPrimaryLocation W18885135251 @default.
• W1888513525 hasRelatedWork W1546989560 @default.
• W1888513525 hasRelatedWork W2059230675 @default.
• W1888513525 hasRelatedWork W2062768126 @default.
• W1888513525 hasRelatedWork W2308164565 @default.
• W1888513525 hasRelatedWork W2320211095 @default.
• W1888513525 hasRelatedWork W2355193834 @default.
• W1888513525 hasRelatedWork W2376003823 @default.
• W1888513525 hasRelatedWork W2907597838 @default.
• W1888513525 hasRelatedWork W3180887190 @default.

• next