FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888594328> ?p ?o ?g. }

• W1888594328 endingPage "2121" @default.
• W1888594328 startingPage "2114" @default.
• W1888594328 abstract "Maternal biotin deficiency is strongly teratogenic in CD-1 mice. The most common malformations are craniofacial and limb defects such as cleft palate, micrognathia and micromelia. The effect of biotin deficiency on palatal development in mouse embryos on d 12 of gestation was studied by culturing mouse embryonic palates in serum-free medium using a suspension culture system. In control embryos palatal processes developed to the fused stage after 72 h in culture. The fusion of palatal processes was further increased by the addition of biotin (10-8 mol/L) to the medium. The addition of organic acids such as propionic, β-methyl crotonic or β-hydroxy isovaleric acids as well as avidin to the medium did not affect the stage of palatal formation. Cycloheximide completely blocked the fusion of palatal shelves. In embryos from biotin-deficient mice, the incidence of fusion between the palatal shelves was <7% and increased to >30% when biotin (10-8-10-6 mol/L) was added to the medium. The addition of fatty acids to the organ culture medium did not have any effect on the fusion of palatal processes. The incorporation of 35S-methionine into protein from biotin-deficient embryo explants was 88% of that in controls. The results indicate that biotin deficiency may interfere directly with synthesis of specific proteins and the formation of palatal processes." @default.
• W1888594328 created "2016-06-24" @default.
• W1888594328 creator A5027839397 @default.
• W1888594328 creator A5031280998 @default.
• W1888594328 creator A5057936074 @default.
• W1888594328 date "1995-08-01" @default.
• W1888594328 modified "2023-10-16" @default.
• W1888594328 title "Biotin Influences Palatal Development of Mouse Embryos in Organ Culture1" @default.
• W1888594328 cites W1416094962 @default.
• W1888594328 cites W1520184516 @default.
• W1888594328 cites W1602350821 @default.
• W1888594328 cites W1608891501 @default.
• W1888594328 cites W1831301545 @default.
• W1888594328 cites W1835460514 @default.
• W1888594328 cites W1967552970 @default.
• W1888594328 cites W1968590155 @default.
• W1888594328 cites W1971987295 @default.
• W1888594328 cites W1979468497 @default.
• W1888594328 cites W1979733421 @default.
• W1888594328 cites W1979769538 @default.
• W1888594328 cites W1987519257 @default.
• W1888594328 cites W1996236419 @default.
• W1888594328 cites W2004966018 @default.
• W1888594328 cites W2030171840 @default.
• W1888594328 cites W2030856157 @default.
• W1888594328 cites W2041731795 @default.
• W1888594328 cites W2057458993 @default.
• W1888594328 cites W2059728727 @default.
• W1888594328 cites W2091767243 @default.
• W1888594328 cites W2135947079 @default.
• W1888594328 cites W2156074368 @default.
• W1888594328 cites W4250626788 @default.
• W1888594328 doi "https://doi.org/10.1093/jn/125.8.2114" @default.
• W1888594328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7643245" @default.
• W1888594328 hasPublicationYear "1995" @default.
• W1888594328 type Work @default.
• W1888594328 sameAs 1888594328 @default.
• W1888594328 citedByCount "51" @default.
• W1888594328 countsByYear W18885943282012 @default.
• W1888594328 countsByYear W18885943282013 @default.
• W1888594328 countsByYear W18885943282017 @default.
• W1888594328 countsByYear W18885943282018 @default.
• W1888594328 countsByYear W18885943282019 @default.
• W1888594328 countsByYear W18885943282020 @default.
• W1888594328 countsByYear W18885943282022 @default.
• W1888594328 crossrefType "journal-article" @default.
• W1888594328 hasAuthorship W1888594328A5027839397 @default.
• W1888594328 hasAuthorship W1888594328A5031280998 @default.
• W1888594328 hasAuthorship W1888594328A5057936074 @default.
• W1888594328 hasConcept C176406525 @default.
• W1888594328 hasConcept C196843134 @default.
• W1888594328 hasConcept C202751555 @default.
• W1888594328 hasConcept C2776294945 @default.
• W1888594328 hasConcept C2778128677 @default.
• W1888594328 hasConcept C2778204606 @default.
• W1888594328 hasConcept C2780912031 @default.
• W1888594328 hasConcept C2781245598 @default.
• W1888594328 hasConcept C28483552 @default.
• W1888594328 hasConcept C3675279 @default.
• W1888594328 hasConcept C515207424 @default.
• W1888594328 hasConcept C54355233 @default.
• W1888594328 hasConcept C55493867 @default.
• W1888594328 hasConcept C86803240 @default.
• W1888594328 hasConcept C87073359 @default.
• W1888594328 hasConcept C95444343 @default.
• W1888594328 hasConceptScore W1888594328C176406525 @default.
• W1888594328 hasConceptScore W1888594328C196843134 @default.
• W1888594328 hasConceptScore W1888594328C202751555 @default.
• W1888594328 hasConceptScore W1888594328C2776294945 @default.
• W1888594328 hasConceptScore W1888594328C2778128677 @default.
• W1888594328 hasConceptScore W1888594328C2778204606 @default.
• W1888594328 hasConceptScore W1888594328C2780912031 @default.
• W1888594328 hasConceptScore W1888594328C2781245598 @default.
• W1888594328 hasConceptScore W1888594328C28483552 @default.
• W1888594328 hasConceptScore W1888594328C3675279 @default.
• W1888594328 hasConceptScore W1888594328C515207424 @default.
• W1888594328 hasConceptScore W1888594328C54355233 @default.
• W1888594328 hasConceptScore W1888594328C55493867 @default.
• W1888594328 hasConceptScore W1888594328C86803240 @default.
• W1888594328 hasConceptScore W1888594328C87073359 @default.
• W1888594328 hasConceptScore W1888594328C95444343 @default.
• W1888594328 hasIssue "8" @default.
• W1888594328 hasLocation W18885943281 @default.
• W1888594328 hasLocation W18885943282 @default.
• W1888594328 hasOpenAccess W1888594328 @default.
• W1888594328 hasPrimaryLocation W18885943281 @default.
• W1888594328 hasRelatedWork W11613253 @default.
• W1888594328 hasRelatedWork W1497685337 @default.
• W1888594328 hasRelatedWork W2006417223 @default.
• W1888594328 hasRelatedWork W2058508517 @default.
• W1888594328 hasRelatedWork W2067157422 @default.
• W1888594328 hasRelatedWork W2075319583 @default.
• W1888594328 hasRelatedWork W2156074368 @default.
• W1888594328 hasRelatedWork W2328930513 @default.
• W1888594328 hasRelatedWork W2333965755 @default.
• W1888594328 hasRelatedWork W2971604732 @default.
• W1888594328 hasVolume "125" @default.
• W1888594328 isParatext "false" @default.

• next