FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888654868> ?p ?o ?g. }

• W1888654868 endingPage "180" @default.
• W1888654868 startingPage "170" @default.
• W1888654868 abstract "Abstract This study aimed to investigate whether apigenin ( API ) suppresses arthritis development through the modulation of dendritic cell functions. Bone marrow‐derived dendritic cells ( BMDC s) were stimulated in vitro with lipopolysaccharide ( LPS ) and treated with API for 24 hrs; DC functions, including phenotype expressions, cytokine secretion, phagocytosis and chemotaxis, were then investigated. The effects of API on collagen‐induced arthritis ( CIA ) were examined in vivo , and purified DC s from the lymph nodes ( LN s) of API ‐treated CIA mice were analysed for phenotypes and subsets. In in vitro , API efficiently restrained the phenotypic and functional maturation of LPS ‐stimulated BMDC s while maintaining phagocytotic capabilities. Moreover, API inhibited the chemotactic responses of LPS ‐stimulated BMDC s, which may be related to the depressive effect on chemokine receptor 4 ( CXCR 4). In in vivo , API treatment delayed the onset and reduced the severity of arthritis in CIA mice, and diminished secretion of pro‐inflammatory cytokines in the serum and supernatants from the LN cells of the CIA mice. Similar to the in vitro findings, the API ‐treated mice exhibited reduced expression of co‐stimulatory molecules and major histocompatibility complex II on DC s. Furthermore, API treatment strongly down‐regulated the number of Langerhans cells, but not plasmacytoid DC s ( pDC s) in LN s, which may be related to the depressive effect of API on the expression of CXCR 4 on DC s of peripheral blood. These data provide new insight into the mechanism of action of API on arthritis and indicate that the inhibition of maturation and migration of DC s by API may contribute to its immunosuppressive effects." @default.
• W1888654868 created "2016-06-24" @default.
• W1888654868 creator A5000352200 @default.
• W1888654868 creator A5007527706 @default.
• W1888654868 creator A5016114761 @default.
• W1888654868 creator A5016655840 @default.
• W1888654868 creator A5025603651 @default.
• W1888654868 creator A5030537255 @default.
• W1888654868 creator A5064968468 @default.
• W1888654868 creator A5067987105 @default.
• W1888654868 creator A5082335856 @default.
• W1888654868 date "2015-10-30" @default.
• W1888654868 modified "2023-10-16" @default.
• W1888654868 title "Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen‐induced arthritis" @default.
• W1888654868 cites W1552993662 @default.
• W1888654868 cites W1661544713 @default.
• W1888654868 cites W1766190356 @default.
• W1888654868 cites W1963531459 @default.
• W1888654868 cites W1964653776 @default.
• W1888654868 cites W1967359155 @default.
• W1888654868 cites W1967415740 @default.
• W1888654868 cites W1986722574 @default.
• W1888654868 cites W1992999021 @default.
• W1888654868 cites W1996595335 @default.
• W1888654868 cites W1998647423 @default.
• W1888654868 cites W2003377779 @default.
• W1888654868 cites W2007453791 @default.
• W1888654868 cites W2044720062 @default.
• W1888654868 cites W2045776270 @default.
• W1888654868 cites W2055744180 @default.
• W1888654868 cites W2056032873 @default.
• W1888654868 cites W2072654660 @default.
• W1888654868 cites W2074438676 @default.
• W1888654868 cites W2074951329 @default.
• W1888654868 cites W2081156561 @default.
• W1888654868 cites W2089162433 @default.
• W1888654868 cites W2090640877 @default.
• W1888654868 cites W2097833923 @default.
• W1888654868 cites W2101436588 @default.
• W1888654868 cites W2102715783 @default.
• W1888654868 cites W2110901553 @default.
• W1888654868 cites W2133899217 @default.
• W1888654868 cites W2134428218 @default.
• W1888654868 cites W2136314388 @default.
• W1888654868 cites W2141399945 @default.
• W1888654868 cites W2146607274 @default.
• W1888654868 cites W2150295492 @default.
• W1888654868 cites W2156486811 @default.
• W1888654868 cites W2163380226 @default.
• W1888654868 cites W2165020893 @default.
• W1888654868 cites W2165558270 @default.
• W1888654868 cites W2166676682 @default.
• W1888654868 cites W2167681235 @default.
• W1888654868 cites W24844550 @default.
• W1888654868 doi "https://doi.org/10.1111/jcmm.12717" @default.
• W1888654868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4717846" @default.
• W1888654868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26515512" @default.
• W1888654868 hasPublicationYear "2015" @default.
• W1888654868 type Work @default.
• W1888654868 sameAs 1888654868 @default.
• W1888654868 citedByCount "50" @default.
• W1888654868 countsByYear W18886548682016 @default.
• W1888654868 countsByYear W18886548682017 @default.
• W1888654868 countsByYear W18886548682018 @default.
• W1888654868 countsByYear W18886548682019 @default.
• W1888654868 countsByYear W18886548682020 @default.
• W1888654868 countsByYear W18886548682021 @default.
• W1888654868 countsByYear W18886548682022 @default.
• W1888654868 countsByYear W18886548682023 @default.
• W1888654868 crossrefType "journal-article" @default.
• W1888654868 hasAuthorship W1888654868A5000352200 @default.
• W1888654868 hasAuthorship W1888654868A5007527706 @default.
• W1888654868 hasAuthorship W1888654868A5016114761 @default.
• W1888654868 hasAuthorship W1888654868A5016655840 @default.
• W1888654868 hasAuthorship W1888654868A5025603651 @default.
• W1888654868 hasAuthorship W1888654868A5030537255 @default.
• W1888654868 hasAuthorship W1888654868A5064968468 @default.
• W1888654868 hasAuthorship W1888654868A5067987105 @default.
• W1888654868 hasAuthorship W1888654868A5082335856 @default.
• W1888654868 hasBestOaLocation W18886548681 @default.
• W1888654868 hasConcept C13373296 @default.
• W1888654868 hasConcept C150903083 @default.
• W1888654868 hasConcept C185592680 @default.
• W1888654868 hasConcept C203014093 @default.
• W1888654868 hasConcept C207001950 @default.
• W1888654868 hasConcept C2776914184 @default.
• W1888654868 hasConcept C2777077863 @default.
• W1888654868 hasConcept C2778004101 @default.
• W1888654868 hasConcept C2778170410 @default.
• W1888654868 hasConcept C2778609962 @default.
• W1888654868 hasConcept C2778690821 @default.
• W1888654868 hasConcept C2779054382 @default.
• W1888654868 hasConcept C55493867 @default.
• W1888654868 hasConcept C86803240 @default.
• W1888654868 hasConcept C8891405 @default.
• W1888654868 hasConcept C95444343 @default.
• W1888654868 hasConceptScore W1888654868C13373296 @default.
• W1888654868 hasConceptScore W1888654868C150903083 @default.

• next