Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888714757> ?p ?o ?g. }
- W1888714757 endingPage "7525" @default.
- W1888714757 startingPage "7517" @default.
- W1888714757 abstract "Contactin (also known as F3, F11) is a surface glycoprotein that has significant homology with the beta2 subunit of voltage-gated Na(+) channels. Contactin and Na(+) channels can be reciprocally coimmunoprecipitated from brain homogenates, indicating association within a complex. Cells cotransfected with Na(+) channel Na(v)1.2alpha and beta1 subunits and contactin have threefold to fourfold higher peak Na(+) currents than cells with Na(v)1.2alpha alone, Na(v)1.2/beta1, Na(v)1.2/contactin, or Na(v)1.2/beta1/beta2. These cells also have a correspondingly higher saxitoxin binding, suggesting an increased Na(+) channel surface membrane density. Coimmunoprecipitation of different subunits from cell lines shows that contactin interacts specifically with the beta1 subunit. In the PNS, immunocytochemical studies show a transient colocalization of contactin and Na(+) channels at new nodes of Ranvier forming during remyelination. In the CNS, there is a particularly high level of colocalization of Na(+) channels and contactin at nodes both during development and in the adult. Contactin may thus significantly influence the functional expression and distribution of Na(+) channels in neurons." @default.
- W1888714757 created "2016-06-24" @default.
- W1888714757 creator A5004973809 @default.
- W1888714757 creator A5006062838 @default.
- W1888714757 creator A5030541297 @default.
- W1888714757 creator A5036686598 @default.
- W1888714757 creator A5041619819 @default.
- W1888714757 creator A5043756865 @default.
- W1888714757 creator A5048331793 @default.
- W1888714757 creator A5054639915 @default.
- W1888714757 creator A5082719482 @default.
- W1888714757 creator A5089069038 @default.
- W1888714757 creator A5090198091 @default.
- W1888714757 date "2001-10-01" @default.
- W1888714757 modified "2023-10-18" @default.
- W1888714757 title "Contactin Associates with Na<sup>+</sup>Channels and Increases Their Functional Expression" @default.
- W1888714757 cites W1517753368 @default.
- W1888714757 cites W1519457709 @default.
- W1888714757 cites W1585222504 @default.
- W1888714757 cites W1788586683 @default.
- W1888714757 cites W1910325974 @default.
- W1888714757 cites W1965458397 @default.
- W1888714757 cites W1968924035 @default.
- W1888714757 cites W1971734837 @default.
- W1888714757 cites W1972238556 @default.
- W1888714757 cites W1991798507 @default.
- W1888714757 cites W1992316691 @default.
- W1888714757 cites W1996988785 @default.
- W1888714757 cites W2006271002 @default.
- W1888714757 cites W2012674134 @default.
- W1888714757 cites W2015556183 @default.
- W1888714757 cites W2016466873 @default.
- W1888714757 cites W2019268667 @default.
- W1888714757 cites W2020714294 @default.
- W1888714757 cites W2027404231 @default.
- W1888714757 cites W2029255000 @default.
- W1888714757 cites W2037384321 @default.
- W1888714757 cites W2050258368 @default.
- W1888714757 cites W2059612947 @default.
- W1888714757 cites W2068555907 @default.
- W1888714757 cites W2068684319 @default.
- W1888714757 cites W2079832984 @default.
- W1888714757 cites W2080537538 @default.
- W1888714757 cites W2082952610 @default.
- W1888714757 cites W2086956125 @default.
- W1888714757 cites W2087138604 @default.
- W1888714757 cites W2088699251 @default.
- W1888714757 cites W2088716212 @default.
- W1888714757 cites W2090336874 @default.
- W1888714757 cites W2093823310 @default.
- W1888714757 cites W2098584548 @default.
- W1888714757 cites W2101895903 @default.
- W1888714757 cites W2103015711 @default.
- W1888714757 cites W2113519237 @default.
- W1888714757 cites W2125417616 @default.
- W1888714757 cites W2137340824 @default.
- W1888714757 cites W2139846514 @default.
- W1888714757 cites W2151915336 @default.
- W1888714757 cites W2161439549 @default.
- W1888714757 cites W2192379666 @default.
- W1888714757 cites W308270796 @default.
- W1888714757 doi "https://doi.org/10.1523/jneurosci.21-19-07517.2001" @default.
- W1888714757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762905" @default.
- W1888714757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11567041" @default.
- W1888714757 hasPublicationYear "2001" @default.
- W1888714757 type Work @default.
- W1888714757 sameAs 1888714757 @default.
- W1888714757 citedByCount "172" @default.
- W1888714757 countsByYear W18887147572012 @default.
- W1888714757 countsByYear W18887147572013 @default.
- W1888714757 countsByYear W18887147572014 @default.
- W1888714757 countsByYear W18887147572015 @default.
- W1888714757 countsByYear W18887147572016 @default.
- W1888714757 countsByYear W18887147572017 @default.
- W1888714757 countsByYear W18887147572018 @default.
- W1888714757 countsByYear W18887147572019 @default.
- W1888714757 countsByYear W18887147572020 @default.
- W1888714757 countsByYear W18887147572021 @default.
- W1888714757 countsByYear W18887147572022 @default.
- W1888714757 countsByYear W18887147572023 @default.
- W1888714757 crossrefType "journal-article" @default.
- W1888714757 hasAuthorship W1888714757A5004973809 @default.
- W1888714757 hasAuthorship W1888714757A5006062838 @default.
- W1888714757 hasAuthorship W1888714757A5030541297 @default.
- W1888714757 hasAuthorship W1888714757A5036686598 @default.
- W1888714757 hasAuthorship W1888714757A5041619819 @default.
- W1888714757 hasAuthorship W1888714757A5043756865 @default.
- W1888714757 hasAuthorship W1888714757A5048331793 @default.
- W1888714757 hasAuthorship W1888714757A5054639915 @default.
- W1888714757 hasAuthorship W1888714757A5082719482 @default.
- W1888714757 hasAuthorship W1888714757A5089069038 @default.
- W1888714757 hasAuthorship W1888714757A5090198091 @default.
- W1888714757 hasBestOaLocation W18887147571 @default.
- W1888714757 hasConcept C104292427 @default.
- W1888714757 hasConcept C104317684 @default.
- W1888714757 hasConcept C12554922 @default.
- W1888714757 hasConcept C153911025 @default.
- W1888714757 hasConcept C170493617 @default.