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- W1888750291 abstract "Epigenetic mechanisms, which involve DNA and histone modifications, result in the heritable silencing of genes without a change in their coding sequence. The study of human disease has focused on genetic mechanisms, but disruption of the balance of epigenetic networks may lead to several major pathologies, including cancer, syndromes involving chromosomal instabilities, and autoimmune diseases. Recent studies on epigenetics, including DNA methylation and its regulatory enzymes, could contribute to the understanding of the rheumatoid arthritis (RA) pathogenesis. Herein, we review the DNA methylation and its importance in RA. Several studies have indicated the importance possible of DNA methylation, especially hypomethylation, in the etiology of RA. As a corollary, epigenetic therapy which includes several inhibitors of enzymes controlling epigenetic modifications, specifically DNA methyltransferases and histone deacetylases, could be a promising treatment of RA." @default.
- W1888750291 created "2016-06-24" @default.
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- W1888750291 date "2006-01-01" @default.
- W1888750291 modified "2023-09-26" @default.
- W1888750291 title "EPIGENÉTICA Y EPIGENÓMICA DE LA ARTRITIS REUMATOIDE" @default.
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