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- W1888760957 abstract "Oligodendrocytes (OLs) are in many ways implicated in the pathophysiology of schizophrenia. However, very little is currently known about possible OL cell cycle disturbances in schizophrenia, a phenomenon which has been described for the birth of new hippocampal neurons in schizophrenics. When morphometrically analyzing the density of prohibitinexpressing OLs in diff erent prefrontal white matter areas of patients with schizophrenia, we found a signifi cantly increased density of this OL subpopulation in the anterior cingulate cortex. Prohibitin is a mitochondrial protein, which is expressed both in neurons and OLs. Among many other functions, this protein plays an important role in the control of cell proliferation and apoptosis by regulating the GTPase OPA1. Hence, out data might be taken as possible hint for disease-related cell cycle abnormalities." @default.
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- W1888760957 date "2010-06-01" @default.
- W1888760957 modified "2023-10-12" @default.
- W1888760957 title "Increased Oligodendroglial Expression of the Cell Proliferation-Controlling Protein Prohibitin in Schizophrenia. A Hint for Cell Cycle Abnormalities?" @default.
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