Matches in SemOpenAlex for { <https://semopenalex.org/work/W1888949612> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1888949612 endingPage "84" @default.
- W1888949612 startingPage "376" @default.
- W1888949612 abstract "The term sialic acid is used to describe derivatives of neuraminic acid, where the amino group of neuraminic acid is substituted by either an acetyl or glycolyl group. The unique structural features of the molecule, which includes a negative charge owing to a carboxyl group, enables it to play a role in cellular functions, such as transport of positively charged compounds, cell-to-cell repulsion, influencing conformation of glycoproteins on cell membranes, and even masking antigenic determinants on receptor molecules. Focus on sialic acid as a tumor marker should be examined from the perspective of aberrant glycosylation in cancer cell membranes owing to activation of new glycosyl transferases that are characteristic of tumor cells, and the role played by sialic acid in tumor cell metastasis including increased capacity to adhere to vascular endothelium, and decreased capacity of cancer cells to be destroyed by host defence mechanisms. The high sensitivity of sialic acid as a tumor marker has been reported in a variety of cancerous conditions. Its specificity, however, is relatively low since there is also an increase in sialic acid-rich glycoproteins in inflammatory diseases. Sialic acid measurements, however, have value in monitoring cancer patients during treatment. A variety of methods are available for the measurement of both total and lipid associated sialic acids in serum or plasma. The newer high performance liquid chromatographic procedures can detect picogram levels of sialic acid and are relatively free of interferences seen with classical procedures." @default.
- W1888949612 created "2016-06-24" @default.
- W1888949612 creator A5080331330 @default.
- W1888949612 date "1994-07-01" @default.
- W1888949612 modified "2023-09-23" @default.
- W1888949612 title "Sialic acid as a tumor marker." @default.
- W1888949612 cites W145362268 @default.
- W1888949612 cites W1536299500 @default.
- W1888949612 cites W1580023435 @default.
- W1888949612 cites W1748902457 @default.
- W1888949612 cites W1904434827 @default.
- W1888949612 cites W1964112957 @default.
- W1888949612 cites W1970376753 @default.
- W1888949612 cites W1970778876 @default.
- W1888949612 cites W1976644790 @default.
- W1888949612 cites W1995602018 @default.
- W1888949612 cites W2001117975 @default.
- W1888949612 cites W2025031941 @default.
- W1888949612 cites W2030701775 @default.
- W1888949612 cites W2035885305 @default.
- W1888949612 cites W2045836151 @default.
- W1888949612 cites W2061109373 @default.
- W1888949612 cites W2079836599 @default.
- W1888949612 cites W2093540558 @default.
- W1888949612 cites W2162983944 @default.
- W1888949612 cites W2286050241 @default.
- W1888949612 cites W30256237 @default.
- W1888949612 cites W63170597 @default.
- W1888949612 cites W2396501495 @default.
- W1888949612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7944275" @default.
- W1888949612 hasPublicationYear "1994" @default.
- W1888949612 type Work @default.
- W1888949612 sameAs 1888949612 @default.
- W1888949612 citedByCount "55" @default.
- W1888949612 countsByYear W18889496122012 @default.
- W1888949612 countsByYear W18889496122013 @default.
- W1888949612 countsByYear W18889496122014 @default.
- W1888949612 countsByYear W18889496122015 @default.
- W1888949612 countsByYear W18889496122016 @default.
- W1888949612 countsByYear W18889496122017 @default.
- W1888949612 countsByYear W18889496122018 @default.
- W1888949612 countsByYear W18889496122019 @default.
- W1888949612 countsByYear W18889496122020 @default.
- W1888949612 countsByYear W18889496122021 @default.
- W1888949612 countsByYear W18889496122022 @default.
- W1888949612 countsByYear W18889496122023 @default.
- W1888949612 crossrefType "journal-article" @default.
- W1888949612 hasAuthorship W1888949612A5080331330 @default.
- W1888949612 hasConcept C108625454 @default.
- W1888949612 hasConcept C185592680 @default.
- W1888949612 hasConcept C2777313579 @default.
- W1888949612 hasConcept C2778671442 @default.
- W1888949612 hasConcept C2780115458 @default.
- W1888949612 hasConcept C2781302033 @default.
- W1888949612 hasConcept C55493867 @default.
- W1888949612 hasConceptScore W1888949612C108625454 @default.
- W1888949612 hasConceptScore W1888949612C185592680 @default.
- W1888949612 hasConceptScore W1888949612C2777313579 @default.
- W1888949612 hasConceptScore W1888949612C2778671442 @default.
- W1888949612 hasConceptScore W1888949612C2780115458 @default.
- W1888949612 hasConceptScore W1888949612C2781302033 @default.
- W1888949612 hasConceptScore W1888949612C55493867 @default.
- W1888949612 hasIssue "4" @default.
- W1888949612 hasLocation W18889496121 @default.
- W1888949612 hasOpenAccess W1888949612 @default.
- W1888949612 hasPrimaryLocation W18889496121 @default.
- W1888949612 hasRelatedWork W1595841096 @default.
- W1888949612 hasRelatedWork W1888949612 @default.
- W1888949612 hasRelatedWork W1983724873 @default.
- W1888949612 hasRelatedWork W1986367195 @default.
- W1888949612 hasRelatedWork W2058269227 @default.
- W1888949612 hasRelatedWork W2060158336 @default.
- W1888949612 hasRelatedWork W2060658253 @default.
- W1888949612 hasRelatedWork W2072826323 @default.
- W1888949612 hasRelatedWork W2117728762 @default.
- W1888949612 hasRelatedWork W3143291213 @default.
- W1888949612 hasVolume "24" @default.
- W1888949612 isParatext "false" @default.
- W1888949612 isRetracted "false" @default.
- W1888949612 magId "1888949612" @default.
- W1888949612 workType "article" @default.