FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1889074712> ?p ?o ?g. }

• W1889074712 endingPage "939" @default.
• W1889074712 startingPage "932" @default.
• W1889074712 abstract "The aim of the present study was to develop amorphous solid dispersion (ASD) of meloxicam (MEL) for providing rapid onset of action. ASDs of MEL with polyvinylpyrrolidone (PVP) K-30 (MEL/PVP), HPC-SSL (MEL/HPC), and Eudragit EPO (MEL/EPO) were prepared. The physicochemical properties were characterized by focusing on morphology, crystallinity, dissolution properties, stability, and the interaction of MEL with coexisting polymers. MEL/EPO was physicochemically stable after storage at 40°C/75% RH for 30 days. In contrast, recrystallization of MEL was observed in MEL/PVP and MEL/HPC at 40°C/50% RH for 30 days. Infrared spectroscopic studies and (1)H NMR analyses of MEL/EPO revealed that Eudragit EPO interacted with MEL and reduced intermolecular binding between MEL molecules. Intermolecular interaction of drug molecules is necessary for the formation of crystalline. Thus, the interaction of MEL with Eudragit EPO and interruption of the formation of supramolecular interaction between MEL molecules might lead to the inhibition of crystal growth of MEL. Of all the MEL solid dispersions prepared, MEL/EPO showed the largest improvement in dissolution behavior. Oral administration of MEL/EPO to rats showed rapid and enhanced MEL exposure with a 2.4-fold increase in bioavailability compared with crystalline MEL. Based on these findings, MEL/EPO was physicochemically stable and provided a rapid onset of action and enhanced bioavailability after oral administration." @default.
• W1889074712 created "2016-06-24" @default.
• W1889074712 creator A5016108030 @default.
• W1889074712 creator A5028019913 @default.
• W1889074712 creator A5032706346 @default.
• W1889074712 creator A5048571795 @default.
• W1889074712 creator A5048661439 @default.
• W1889074712 creator A5053778755 @default.
• W1889074712 creator A5069565529 @default.
• W1889074712 date "2015-10-05" @default.
• W1889074712 modified "2023-10-03" @default.
• W1889074712 title "Physicochemical and Pharmacokinetic Characterization of Amorphous Solid Dispersion of Meloxicam with Enhanced Dissolution Property and Storage Stability" @default.
• W1889074712 cites W1964693547 @default.
• W1889074712 cites W1977706372 @default.
• W1889074712 cites W1989295556 @default.
• W1889074712 cites W1999899011 @default.
• W1889074712 cites W2020068592 @default.
• W1889074712 cites W2023677520 @default.
• W1889074712 cites W2041517295 @default.
• W1889074712 cites W2044594845 @default.
• W1889074712 cites W2075511045 @default.
• W1889074712 cites W2080856181 @default.
• W1889074712 cites W2085378313 @default.
• W1889074712 cites W2091794461 @default.
• W1889074712 cites W2120076778 @default.
• W1889074712 cites W2152005190 @default.
• W1889074712 cites W2156829937 @default.
• W1889074712 cites W2318219585 @default.
• W1889074712 cites W53851219 @default.
• W1889074712 doi "https://doi.org/10.1208/s12249-015-0422-x" @default.
• W1889074712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27435198" @default.
• W1889074712 hasPublicationYear "2015" @default.
• W1889074712 type Work @default.
• W1889074712 sameAs 1889074712 @default.
• W1889074712 citedByCount "14" @default.
• W1889074712 countsByYear W18890747122017 @default.
• W1889074712 countsByYear W18890747122018 @default.
• W1889074712 countsByYear W18890747122019 @default.
• W1889074712 countsByYear W18890747122020 @default.
• W1889074712 countsByYear W18890747122021 @default.
• W1889074712 countsByYear W18890747122022 @default.
• W1889074712 countsByYear W18890747122023 @default.
• W1889074712 crossrefType "journal-article" @default.
• W1889074712 hasAuthorship W1889074712A5016108030 @default.
• W1889074712 hasAuthorship W1889074712A5028019913 @default.
• W1889074712 hasAuthorship W1889074712A5032706346 @default.
• W1889074712 hasAuthorship W1889074712A5048571795 @default.
• W1889074712 hasAuthorship W1889074712A5048661439 @default.
• W1889074712 hasAuthorship W1889074712A5053778755 @default.
• W1889074712 hasAuthorship W1889074712A5069565529 @default.
• W1889074712 hasBestOaLocation W18890747121 @default.
• W1889074712 hasConcept C112705442 @default.
• W1889074712 hasConcept C13965031 @default.
• W1889074712 hasConcept C151730666 @default.
• W1889074712 hasConcept C178790620 @default.
• W1889074712 hasConcept C181389837 @default.
• W1889074712 hasConcept C185592680 @default.
• W1889074712 hasConcept C195702682 @default.
• W1889074712 hasConcept C2779751750 @default.
• W1889074712 hasConcept C2780077769 @default.
• W1889074712 hasConcept C46275449 @default.
• W1889074712 hasConcept C56052488 @default.
• W1889074712 hasConcept C71924100 @default.
• W1889074712 hasConcept C8010536 @default.
• W1889074712 hasConcept C86803240 @default.
• W1889074712 hasConcept C88380143 @default.
• W1889074712 hasConcept C98274493 @default.
• W1889074712 hasConceptScore W1889074712C112705442 @default.
• W1889074712 hasConceptScore W1889074712C13965031 @default.
• W1889074712 hasConceptScore W1889074712C151730666 @default.
• W1889074712 hasConceptScore W1889074712C178790620 @default.
• W1889074712 hasConceptScore W1889074712C181389837 @default.
• W1889074712 hasConceptScore W1889074712C185592680 @default.
• W1889074712 hasConceptScore W1889074712C195702682 @default.
• W1889074712 hasConceptScore W1889074712C2779751750 @default.
• W1889074712 hasConceptScore W1889074712C2780077769 @default.
• W1889074712 hasConceptScore W1889074712C46275449 @default.
• W1889074712 hasConceptScore W1889074712C56052488 @default.
• W1889074712 hasConceptScore W1889074712C71924100 @default.
• W1889074712 hasConceptScore W1889074712C8010536 @default.
• W1889074712 hasConceptScore W1889074712C86803240 @default.
• W1889074712 hasConceptScore W1889074712C88380143 @default.
• W1889074712 hasConceptScore W1889074712C98274493 @default.
• W1889074712 hasIssue "4" @default.
• W1889074712 hasLocation W18890747121 @default.
• W1889074712 hasLocation W18890747122 @default.
• W1889074712 hasOpenAccess W1889074712 @default.
• W1889074712 hasPrimaryLocation W18890747121 @default.
• W1889074712 hasRelatedWork W1976019421 @default.
• W1889074712 hasRelatedWork W2011931998 @default.
• W1889074712 hasRelatedWork W2014390215 @default.
• W1889074712 hasRelatedWork W2043028328 @default.
• W1889074712 hasRelatedWork W2055845628 @default.
• W1889074712 hasRelatedWork W2080955156 @default.
• W1889074712 hasRelatedWork W2355468301 @default.
• W1889074712 hasRelatedWork W2366157691 @default.
• W1889074712 hasRelatedWork W2372245366 @default.
• W1889074712 hasRelatedWork W2407692144 @default.

• next