FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1889173857> ?p ?o ?g. }

• W1889173857 endingPage "481" @default.
• W1889173857 startingPage "473" @default.
• W1889173857 abstract "The influences of castration and of subsequent replacement therapy with gonadal hormones on the secretion of prolactin (PRL) and growth hormone (GH) in male and female mice were investigated. Long term castration in female mice significantly reduced basal and perphenazine-indueed PRL levels in the serum and PRL cOncentrations in the pituitary gland. Treatment with a moderate dose (1 pg/day) of estradiol benzoate (EB) for several weeks increased PRL levels in the pituitary gland and serum, but the release of PRL in response to perphenazine was not augmented. A large dose of EB(20�sg/day), on the other hand, resulted in a smaller increase in pituitary concentrations, little or no increase in basal serum levels and complete abolition of perphenazine-induced PRL release, suggesting that high doses of EB are detrimental to the release of PRL. In male mice, castration had little or no effect on PRL levels in the pituitary gland or on basal concentrations in serum, but it significantly reduced perphenazine-induced release of PRL. Administration of testosterone (0.5 mg/day) only marginally enhanced pituitary and serum concentrations of PRL, whereas EB injection (1 11g/day) increased serum and pituitary PRL concentrations severalfold. However, neither testosterone nor EB treatment of orehideetomized males could cause serum PRL concentrations to rise after injection of perphenazine to levels equivalent to those in intact females. This suggests that the sex difference in the control of PRL secretion in adult mice involves the pituitary-hypothalamic system rather than the gonad. Concentrations of GH in the pituitary glands and sera of female mice increased following castration, whereas administration of EB (1 pg/day) decreased basal levels of GH in serum and prevented the usual posteastration rise in serum and pituitary GH. In male mice, in contrast, castration reduced pituitary GH concentrations but had no marked influence on serum GH. Administration of testosterone (0.5 mg/day), in turn, increased pituitary GH concentrations, with no appreciable influence on serum GH. These results indicate that the female gonad exerts a net inhibitory influence on GH secretion in female mice, whereas, although essential for maintaining normal levels in the pituitary gland, the male gonad has little influence on the circulating levels of GH in male mice." @default.
• W1889173857 created "2016-06-24" @default.
• W1889173857 creator A5030455939 @default.
• W1889173857 creator A5049871603 @default.
• W1889173857 creator A5053468467 @default.
• W1889173857 creator A5076994804 @default.
• W1889173857 date "1979-09-01" @default.
• W1889173857 modified "2023-09-27" @default.
• W1889173857 title "Gonadal Regulation of Prolactin and Growth Hormone Secretion in the Mouse" @default.
• W1889173857 cites W1791080610 @default.
• W1889173857 cites W1971621419 @default.
• W1889173857 cites W1974972822 @default.
• W1889173857 cites W1975836044 @default.
• W1889173857 cites W1976046984 @default.
• W1889173857 cites W1989920625 @default.
• W1889173857 cites W1992458486 @default.
• W1889173857 cites W2018495851 @default.
• W1889173857 cites W2027351488 @default.
• W1889173857 cites W2028515197 @default.
• W1889173857 cites W2034756725 @default.
• W1889173857 cites W2041800616 @default.
• W1889173857 cites W2042222473 @default.
• W1889173857 cites W2042255866 @default.
• W1889173857 cites W2043089512 @default.
• W1889173857 cites W2061975024 @default.
• W1889173857 cites W2069911118 @default.
• W1889173857 cites W2073401201 @default.
• W1889173857 cites W2075006883 @default.
• W1889173857 cites W2083376505 @default.
• W1889173857 cites W2094103746 @default.
• W1889173857 cites W2095039002 @default.
• W1889173857 cites W2095513100 @default.
• W1889173857 cites W2097080186 @default.
• W1889173857 cites W2103323006 @default.
• W1889173857 cites W2104241484 @default.
• W1889173857 cites W2142532942 @default.
• W1889173857 cites W2148979367 @default.
• W1889173857 cites W2290913308 @default.
• W1889173857 cites W2313159711 @default.
• W1889173857 cites W2321650879 @default.
• W1889173857 cites W2334304578 @default.
• W1889173857 cites W2410758470 @default.
• W1889173857 cites W2620127211 @default.
• W1889173857 cites W2122370082 @default.
• W1889173857 cites W2334896575 @default.
• W1889173857 cites W2738486034 @default.
• W1889173857 doi "https://doi.org/10.1093/biolreprod/21.2.473" @default.
• W1889173857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/486669" @default.
• W1889173857 hasPublicationYear "1979" @default.
• W1889173857 type Work @default.
• W1889173857 sameAs 1889173857 @default.
• W1889173857 citedByCount "23" @default.
• W1889173857 countsByYear W18891738572013 @default.
• W1889173857 countsByYear W18891738572015 @default.
• W1889173857 countsByYear W18891738572018 @default.
• W1889173857 crossrefType "journal-article" @default.
• W1889173857 hasAuthorship W1889173857A5030455939 @default.
• W1889173857 hasAuthorship W1889173857A5049871603 @default.
• W1889173857 hasAuthorship W1889173857A5053468467 @default.
• W1889173857 hasAuthorship W1889173857A5076994804 @default.
• W1889173857 hasConcept C126322002 @default.
• W1889173857 hasConcept C134018914 @default.
• W1889173857 hasConcept C2779064019 @default.
• W1889173857 hasConcept C2984496839 @default.
• W1889173857 hasConcept C49039625 @default.
• W1889173857 hasConcept C71315377 @default.
• W1889173857 hasConcept C71924100 @default.
• W1889173857 hasConcept C86803240 @default.
• W1889173857 hasConceptScore W1889173857C126322002 @default.
• W1889173857 hasConceptScore W1889173857C134018914 @default.
• W1889173857 hasConceptScore W1889173857C2779064019 @default.
• W1889173857 hasConceptScore W1889173857C2984496839 @default.
• W1889173857 hasConceptScore W1889173857C49039625 @default.
• W1889173857 hasConceptScore W1889173857C71315377 @default.
• W1889173857 hasConceptScore W1889173857C71924100 @default.
• W1889173857 hasConceptScore W1889173857C86803240 @default.
• W1889173857 hasIssue "2" @default.
• W1889173857 hasLocation W18891738571 @default.
• W1889173857 hasLocation W18891738572 @default.
• W1889173857 hasOpenAccess W1889173857 @default.
• W1889173857 hasPrimaryLocation W18891738571 @default.
• W1889173857 hasRelatedWork W1965498821 @default.
• W1889173857 hasRelatedWork W1966296538 @default.
• W1889173857 hasRelatedWork W1972051303 @default.
• W1889173857 hasRelatedWork W1990896009 @default.
• W1889173857 hasRelatedWork W2033209790 @default.
• W1889173857 hasRelatedWork W2047160720 @default.
• W1889173857 hasRelatedWork W2152306407 @default.
• W1889173857 hasRelatedWork W2158583837 @default.
• W1889173857 hasRelatedWork W2161296685 @default.
• W1889173857 hasRelatedWork W4241810725 @default.
• W1889173857 hasVolume "21" @default.
• W1889173857 isParatext "false" @default.
• W1889173857 isRetracted "false" @default.
• W1889173857 magId "1889173857" @default.
• W1889173857 workType "article" @default.