FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1889240260> ?p ?o ?g. }

• W1889240260 endingPage "34" @default.
• W1889240260 startingPage "23" @default.
• W1889240260 abstract "C1q deficiency is related strongly to systemic lupus erythematosus (SLE), but very few and inconsistent studies explored the single nucleotide polymorphisms of the C1q gene in relation to juvenile SLE (jSLE) and lupus nephritis (LN). The objective of this study was to analyse whether C1q rs 292001 polymorphism is associated with SLE and disease phenotype, especially nephritis, and to investigate the relation between this polymorphism and clinical data, treatment outcome, serum level of C1q protein and antibodies. Typing of C1q rs292001 polymorphism using restriction fragment length polymorphism and measuring serum levels of C1q protein and antibodies by enzyme-linked immunosorbent assay (ELISA) were performed for 130 children with SLE and 208 healthy controls. The A allele of C1q rs292001 was associated with jSLE and LN (P = 0·005 and 0·013, respectively) and the AA genotype was associated with jSLE (P = 0·036). Low serum levels of C1q protein were found in jSLE and LN (P < 0·001 and 0·009, respectively), and these levels were increased after treatment in patients with LN (P = 0·009) and active renal disease (P = 0·027). Higher titres of C1q antibodies were found in patients with LN (P = 0·015) and correlated negatively with C1q protein level (P < 0·001) and patient age (P = 0·04). The A allele and AA genotype of C1q rs292001 can be considered a susceptibility risk factor and the GG genotype could be considered protective for jSLE and LN in the studied cohort of Egyptian children. Decreased serum levels of C1q protein and increased titres of C1q antibodies may be involved in the pathogenesis of jSLE, especially LN." @default.
• W1889240260 created "2016-06-24" @default.
• W1889240260 creator A5026634237 @default.
• W1889240260 creator A5044574440 @default.
• W1889240260 creator A5051485018 @default.
• W1889240260 creator A5054516403 @default.
• W1889240260 creator A5066904684 @default.
• W1889240260 creator A5068887295 @default.
• W1889240260 creator A5074056463 @default.
• W1889240260 creator A5079299401 @default.
• W1889240260 creator A5083144346 @default.
• W1889240260 creator A5091851347 @default.
• W1889240260 date "2015-07-28" @default.
• W1889240260 modified "2023-09-27" @default.
• W1889240260 title "<i>C1q</i>rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis" @default.
• W1889240260 cites W1498368498 @default.
• W1889240260 cites W1537575434 @default.
• W1889240260 cites W1567114372 @default.
• W1889240260 cites W1820570900 @default.
• W1889240260 cites W1852489937 @default.
• W1889240260 cites W1966665855 @default.
• W1889240260 cites W1972228386 @default.
• W1889240260 cites W1974211648 @default.
• W1889240260 cites W1978144128 @default.
• W1889240260 cites W1983625057 @default.
• W1889240260 cites W1985705893 @default.
• W1889240260 cites W1986941515 @default.
• W1889240260 cites W1988481978 @default.
• W1889240260 cites W2000574489 @default.
• W1889240260 cites W2001711330 @default.
• W1889240260 cites W2006176779 @default.
• W1889240260 cites W2030134252 @default.
• W1889240260 cites W2034827064 @default.
• W1889240260 cites W2036126415 @default.
• W1889240260 cites W2040759013 @default.
• W1889240260 cites W2043681291 @default.
• W1889240260 cites W2048088767 @default.
• W1889240260 cites W2048753387 @default.
• W1889240260 cites W2051713980 @default.
• W1889240260 cites W2053142028 @default.
• W1889240260 cites W2053720299 @default.
• W1889240260 cites W2054065273 @default.
• W1889240260 cites W2056167202 @default.
• W1889240260 cites W2059569484 @default.
• W1889240260 cites W2065505163 @default.
• W1889240260 cites W2067217824 @default.
• W1889240260 cites W2070527591 @default.
• W1889240260 cites W2070909340 @default.
• W1889240260 cites W2071662061 @default.
• W1889240260 cites W2074721716 @default.
• W1889240260 cites W2092330145 @default.
• W1889240260 cites W2101246053 @default.
• W1889240260 cites W2110752613 @default.
• W1889240260 cites W2114362413 @default.
• W1889240260 cites W2139574551 @default.
• W1889240260 cites W2142058826 @default.
• W1889240260 cites W2146203649 @default.
• W1889240260 cites W2157745361 @default.
• W1889240260 cites W2169637270 @default.
• W1889240260 cites W2254618780 @default.
• W1889240260 cites W2322953276 @default.
• W1889240260 cites W2396412468 @default.
• W1889240260 cites W2396499394 @default.
• W1889240260 cites W2402484949 @default.
• W1889240260 cites W2418532437 @default.
• W1889240260 cites W4232872423 @default.
• W1889240260 cites W2094679025 @default.
• W1889240260 doi "https://doi.org/10.1111/cei.12666" @default.
• W1889240260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4578505" @default.
• W1889240260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26095468" @default.
• W1889240260 hasPublicationYear "2015" @default.
• W1889240260 type Work @default.
• W1889240260 sameAs 1889240260 @default.
• W1889240260 citedByCount "20" @default.
• W1889240260 countsByYear W18892402602015 @default.
• W1889240260 countsByYear W18892402602016 @default.
• W1889240260 countsByYear W18892402602017 @default.
• W1889240260 countsByYear W18892402602018 @default.
• W1889240260 countsByYear W18892402602019 @default.
• W1889240260 countsByYear W18892402602020 @default.
• W1889240260 countsByYear W18892402602021 @default.
• W1889240260 countsByYear W18892402602022 @default.
• W1889240260 countsByYear W18892402602023 @default.
• W1889240260 crossrefType "journal-article" @default.
• W1889240260 hasAuthorship W1889240260A5026634237 @default.
• W1889240260 hasAuthorship W1889240260A5044574440 @default.
• W1889240260 hasAuthorship W1889240260A5051485018 @default.
• W1889240260 hasAuthorship W1889240260A5054516403 @default.
• W1889240260 hasAuthorship W1889240260A5066904684 @default.
• W1889240260 hasAuthorship W1889240260A5068887295 @default.
• W1889240260 hasAuthorship W1889240260A5074056463 @default.
• W1889240260 hasAuthorship W1889240260A5079299401 @default.
• W1889240260 hasAuthorship W1889240260A5083144346 @default.
• W1889240260 hasAuthorship W1889240260A5091851347 @default.
• W1889240260 hasBestOaLocation W18892402601 @default.
• W1889240260 hasConcept C104317684 @default.
• W1889240260 hasConcept C126322002 @default.
• W1889240260 hasConcept C135763542 @default.

• next