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- W1889302689 endingPage "3625" @default.
- W1889302689 startingPage "3612" @default.
- W1889302689 abstract "The growth and survival of multicellular organisms depend upon their abilities to acquire and metabolize nutrients, efficiently store and harness energy, and sense and fight infection. Systems for sensing and using nutrients have consequently coevolved alongside systems for sensing and responding to danger signals, including pathogens, and share many of the same cell signaling proteins and networks. Diets rich in carbohydrates and fats can overload these systems, leading to obesity, metabolic dysfunction, impaired immunity, and cardiovascular disease. Excessive nutrient intake promotes adiposity, typically altering adipocyte function and immune cell distribution, both of which trigger metabolic dysfunction. Here, we discuss novel mechanistic links between metabolism and immunity that underlie metabolic dysfunction in obesity. We aim to stimulate debate about how the endocrine and immune systems are connected through autocrine, paracrine, and neuroendocrine signaling in sophisticated networks that are only now beginning to be resolved. Understanding the expression and action of signaling proteins, together with modulating their receptors or pattern recognition using agonists or antagonists, will enable rational intervention in immunometabolism that may lead to novel treatments for obesity and metabolic dysfunction." @default.
- W1889302689 created "2016-06-24" @default.
- W1889302689 creator A5000147533 @default.
- W1889302689 creator A5046558354 @default.
- W1889302689 creator A5053439487 @default.
- W1889302689 creator A5063280122 @default.
- W1889302689 creator A5081497233 @default.
- W1889302689 date "2015-09-01" @default.
- W1889302689 modified "2023-10-15" @default.
- W1889302689 title "Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease" @default.
- W1889302689 cites W1496300643 @default.
- W1889302689 cites W1535970076 @default.
- W1889302689 cites W1570594736 @default.
- W1889302689 cites W1637971961 @default.
- W1889302689 cites W1964607854 @default.
- W1889302689 cites W1965955937 @default.
- W1889302689 cites W1966336914 @default.
- W1889302689 cites W1968086274 @default.
- W1889302689 cites W1971604081 @default.
- W1889302689 cites W1972483153 @default.
- W1889302689 cites W1975296949 @default.
- W1889302689 cites W1977390310 @default.
- W1889302689 cites W1977629315 @default.
- W1889302689 cites W1978713271 @default.
- W1889302689 cites W1979259778 @default.
- W1889302689 cites W1985640778 @default.
- W1889302689 cites W1986098635 @default.
- W1889302689 cites W1986751051 @default.
- W1889302689 cites W1987050934 @default.
- W1889302689 cites W1987887433 @default.
- W1889302689 cites W1989780865 @default.
- W1889302689 cites W1990902267 @default.
- W1889302689 cites W1991845771 @default.
- W1889302689 cites W1992384171 @default.
- W1889302689 cites W1992872198 @default.
- W1889302689 cites W2000054651 @default.
- W1889302689 cites W2001167919 @default.
- W1889302689 cites W2003849432 @default.
- W1889302689 cites W2004616503 @default.
- W1889302689 cites W2006474213 @default.
- W1889302689 cites W2009492665 @default.
- W1889302689 cites W2010957046 @default.
- W1889302689 cites W2011709384 @default.
- W1889302689 cites W2013744734 @default.
- W1889302689 cites W2020843850 @default.
- W1889302689 cites W2023774123 @default.
- W1889302689 cites W2025772141 @default.
- W1889302689 cites W2030951641 @default.
- W1889302689 cites W2035489548 @default.
- W1889302689 cites W2037707845 @default.
- W1889302689 cites W2039033342 @default.
- W1889302689 cites W2041136224 @default.
- W1889302689 cites W2041886157 @default.
- W1889302689 cites W2042144976 @default.
- W1889302689 cites W2043225484 @default.
- W1889302689 cites W2043394717 @default.
- W1889302689 cites W2046948130 @default.
- W1889302689 cites W2051587831 @default.
- W1889302689 cites W2051633940 @default.
- W1889302689 cites W2052638070 @default.
- W1889302689 cites W2052889441 @default.
- W1889302689 cites W2056879548 @default.
- W1889302689 cites W2057182111 @default.
- W1889302689 cites W2057337991 @default.
- W1889302689 cites W2057428444 @default.
- W1889302689 cites W2057923834 @default.
- W1889302689 cites W2058702894 @default.
- W1889302689 cites W2058878445 @default.
- W1889302689 cites W2059261163 @default.
- W1889302689 cites W2060236131 @default.
- W1889302689 cites W2060684229 @default.
- W1889302689 cites W2065678433 @default.
- W1889302689 cites W2065987916 @default.
- W1889302689 cites W2066080857 @default.
- W1889302689 cites W2067572657 @default.
- W1889302689 cites W2067576104 @default.
- W1889302689 cites W2067875627 @default.
- W1889302689 cites W2068445992 @default.
- W1889302689 cites W2068538075 @default.
- W1889302689 cites W2069746141 @default.
- W1889302689 cites W2070109729 @default.
- W1889302689 cites W2070855360 @default.
- W1889302689 cites W2070971699 @default.
- W1889302689 cites W2071754972 @default.
- W1889302689 cites W2072881400 @default.
- W1889302689 cites W2073332363 @default.
- W1889302689 cites W2074303577 @default.
- W1889302689 cites W2076462960 @default.
- W1889302689 cites W2077033935 @default.
- W1889302689 cites W2077930526 @default.
- W1889302689 cites W2079148313 @default.
- W1889302689 cites W2079395662 @default.
- W1889302689 cites W2081133644 @default.
- W1889302689 cites W2082113374 @default.
- W1889302689 cites W2082622955 @default.
- W1889302689 cites W2083260532 @default.
- W1889302689 cites W2089783517 @default.
- W1889302689 cites W2090556647 @default.