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- W1889370028 abstract "This chapter provides an overview of autoimmune coagulation disorders to help clinicians and clinical investigators to establish an early diagnosis. Disorders related to coagulation factor autoimmunity are rare but underestimated. Clinical manifestations are obviously dominated by bleeding, but these can be acute and life-threatening, or progressive with formation of hematomas in various organs. The circumstances under which an autoimmune coagulation disorder appears also vary from spontaneous occurrence in an otherwise healthy individual, as a complication in the context of a systemic autoimmune disease, to association with postpartum, surgery, drug intake, or exposure to a cross-reactive antigen. The chapter also discusses the general organization of the coagulation system. In vivo, the coagulation process is initiated when tissue factor (TF) expressed on injured vessel walls is exposed to activate Factor VII in the bloodstream. Small amounts of thrombin are generated through activation of Factor IX and Factor X. Thrombin activates Factor VIII and Factor V, thereby triggering an amplification phase through the formation of the tenase complex, which converts Factor X to its activated form, and the prothrombinase complex, which converts prothrombin into thrombin." @default.
- W1889370028 created "2016-06-24" @default.
- W1889370028 creator A5073433620 @default.
- W1889370028 date "2006-01-01" @default.
- W1889370028 modified "2023-09-25" @default.
- W1889370028 title "Clotting Disorders" @default.
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- W1889370028 doi "https://doi.org/10.1016/b978-012595961-2/50048-2" @default.
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