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- W188940231 abstract "Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Eclipta alba Hassk [ Asteraceae], Hibiscus rosa sinensis Linn [Malvaceae], Nardostachys Jatamansi [ Valerianaceae] is a well known Ayurvedic herb with purported claims of hair growth promotion. Hair formulation of Eclipta alba Hassk [ Asteraceae ] 10% w/v, Hibiscus rosa sinensis Linn [ Malvaceae ] 10 % w/v, Nardostachys jatamansi [ Valerianceae ] 5 % w/v concentration in the form of herbal oil were studied and showed excellent hair growth activity with standard [ 2 % minoxidil ethanolic solution] in wister albino rats. Hair growth initiation time was significantly reduced to half on treatment with the oil, as compared to control animals. The time required for complete hair growth was also significantly reduced. Quantitative analysis of hair growth after treatment with oil exhibited greater number of hair follicles in anagenic phase [ 82 ] which were higher as compared to control [ 52 ]. The result of treatment with oil were better than the positive control minoxidil 2 % treatment. It holds the promise of potent herbal alternative for minoxidil . Key-words : Herbal hair formulation, Asteraceae, Malvaceae, Valerianaceae. Introduction Hair is one of the vital parts of the body derived from ectoderm of skin, is protective appendages on the body and considered accessory structure of the integument along with sebaceous glands, sweat glands and nails.They are known as epidermal derivatives as they originate from the epidermis during embryological development. Hair is an important of the overall appeal of the human body.Alopecia, is dermatological disorder that has been recognized for more than 2000 years is a common problem in cosmetics as well as Primary Health Care Practice. It is common throughout the world and has been estimated to affect between 0.2 % and 2% of the world population. Synthetic drug, minoxidil is a potent vasodilator was scientifically proved for the treatment of alopecia 6-7 .Though the use of drugs for its side effect is not advisable, the drug of plant origin is necessary to replace the synthetic one. Hence the present study was aimed to evaluate the hair growth activity of herbal formulation which includes Eclipta alba Hassk [ 10 % w/v], Hibiscus rosa sinensis Linn [ 10 % w/v], Nardostachys jatamansi [ 5 % w/v] concentration in oil. Bhavaprakash, an Ayurvedic treatise mentions the use of drug for the treatment of “Indralupta” i.e. drug used in the treatment of hair loss. Eclipta alba Hassk [Asteraceae], Hibiscus rosa sinensis [ Malvaceae ], Nardostachys jatamansi [ Valerianaceae] is such herb with traditional claims of hair growth promotion .Eclipta alba is small much branched annual herb with white flower heads found in moist situation throughout India ascending up to 600 feet, grows just after the first showers of rainy season. It is used for hair growth promoter, improving the luster of the hair, treatment of variety of human ailments, particularly liver disorders, wound healing .The herb Hibiscus rosa sinensis Linn [ Malvaceae ] is a glabrous shrub widely cultivated in the tropics as an ornamental plant and has several forms with varying clour of flowers. The leaves and flowers are observed to be promoters of hair growth and aid in healing of ulcers. Flowers have been found to be effective in the treatment of arterial hypertension and have significant antifertility effect. Dried rhizome of Nardostachys jatamansi DC [ Valerianaceae ] is a small herbaceous Himalayan genus, common in Garhwal, Kumaun and Sikkim Himalaya between 3000m and 5000m. It is used for hair growth , convulsions, sedative, treatment of hypertension, dysuria, cystitis and uterine inflammation . V. M. Jadhav et al /Int.J. PharmTech Res.2009,1(4) 1252 Materials and Methods Collection and authentication of plant The leaves of Eclipta alba, flowers of Hibiscus rosa sinensis, rhizomes of Nardostachys jatamansi were purchased from local market and authenticated by Agharkar Research Institute, Pune. The various parts of plant drugs are crushed in mixed and passed through the sieve number 80. The various powder drugs were subjected to pharmacognostic studies for confirmation. Preparation of Combined drug herbal hair formulation of different concentration : After confirming the literature survey , Eclipta alba, Hibiscus rosa sinensis, Nardostachys jatamansi were selected and mixed in 3 different concentration for maximum activity [ Table 1 ]. The formula of base contain coconut oil. Table 1 : Selection of concentration of oil for hair growth activity Amount of drugs / 100 ml of Oil g. Formulations Eclipta alba % Hibiscus rosa sinensis % Nardostachys jatamansi % Eclipta albaJuice ml" @default.
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- W188940231 date "2009-01-01" @default.
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- W188940231 title "Development and evaluation of polyherbal formulations for hair growth-promoting activity." @default.
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