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- W1889629465 abstract "Abstract The X chromosome invariably has the largest effect on postzygotic isolation between animal species. One explanation of this pattern is that inviability and sterility result from a breakdown in the dosage compensation of X-linked genes in hybrids. In Drosophila, such breakdown could result from divergence of the genes used to assess the X/autosomal (X/A) ratio, and thus the sex, of an individual. I test this hypothesis by introducing mutant alleles of the Sex-lethal locus into Drosophila melanogaster-Drosophila simulans hybrids. These mutants ignore any perceived anomalous X/A ratio and thus can be used to ensure proper dosage compensation in hybrids. These mutants do not rescue hybrid viability or fertility, implying that postzygotic isolation in this hybridization does not result from a disruption of dosage compensation caused by divergence of the X/A counting system." @default.
- W1889629465 created "2016-06-24" @default.
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- W1889629465 date "1989-08-01" @default.
- W1889629465 modified "2023-10-17" @default.
- W1889629465 title "Does postzygotic isolation result from improper dosage compensation?" @default.
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- W1889629465 doi "https://doi.org/10.1093/genetics/122.4.891" @default.
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