FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1889926369> ?p ?o ?g. }

• W1889926369 endingPage "321" @default.
• W1889926369 startingPage "314" @default.
• W1889926369 abstract "The src gene of Rous sarcoma virus (v-src) and its cellular homolog, the c-src gene, share extensive sequence homology. The most notable differences between these genes reside in the region encoding the carboxy terminus of the src proteins. We constructed mutations within the 3' end of the v-src gene to determine the significance of this region to the transforming potential of the v-src protein, pp60v-src. The mutants CHdl300 and CHis1511 contain mutations that alter the last 23 amino acids of pp60v-src, whereas the mutant CHis1545-C contains a linker insertion that alters the last 11 amino acids of pp60v-src, and the mutant CHis1545-H contains a linker insertion that results in a 9-amino-acid insertion at position 415. Plasmids bearing each of these mutations were unable to transform chicken cells when introduced into these cells by DNA transfection. In addition, the structurally altered src proteins encoded by the mutants had much-reduced levels of tyrosine protein kinase activity in vivo, as measured by autophosphorylation and phosphorylation of the 34,000-Mr cellular protein, and in vitro, as determined by measuring the level of pp60src autophosphorylation. These data indicate that the carboxy-terminal amino acid sequences play an important role in maintaining the structure of the catalytic domain of pp60v-src. In contrast, the transfection of chicken cells with plasmid DNA containing a chimeric v-c-src gene resulted in morphological cell transformation and the synthesis of an enzymatically active hybrid protein. Therefore, the carboxy-terminal sequence alterations observed in the c-src protein do not alone serve to alter the functional activity of a hybrid v-c-src protein appreciably." @default.
• W1889926369 created "2016-06-24" @default.
• W1889926369 creator A5019699752 @default.
• W1889926369 creator A5055474312 @default.
• W1889926369 creator A5081166831 @default.
• W1889926369 date "1985-08-01" @default.
• W1889926369 modified "2023-09-27" @default.
• W1889926369 title "Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation" @default.
• W1889926369 cites W1492857624 @default.
• W1889926369 cites W1494533689 @default.
• W1889926369 cites W1495359295 @default.
• W1889926369 cites W1558516755 @default.
• W1889926369 cites W1586543565 @default.
• W1889926369 cites W1588885776 @default.
• W1889926369 cites W1591626787 @default.
• W1889926369 cites W1772692742 @default.
• W1889926369 cites W1827979469 @default.
• W1889926369 cites W1838164920 @default.
• W1889926369 cites W1892388442 @default.
• W1889926369 cites W1893943343 @default.
• W1889926369 cites W1897669544 @default.
• W1889926369 cites W1922625104 @default.
• W1889926369 cites W1929752858 @default.
• W1889926369 cites W1931042715 @default.
• W1889926369 cites W1971333358 @default.
• W1889926369 cites W1976508520 @default.
• W1889926369 cites W1976782840 @default.
• W1889926369 cites W1980294596 @default.
• W1889926369 cites W1981671523 @default.
• W1889926369 cites W1987145868 @default.
• W1889926369 cites W1991486518 @default.
• W1889926369 cites W1995729295 @default.
• W1889926369 cites W1999214130 @default.
• W1889926369 cites W1999477520 @default.
• W1889926369 cites W2002338830 @default.
• W1889926369 cites W2003570140 @default.
• W1889926369 cites W2008226643 @default.
• W1889926369 cites W2011147958 @default.
• W1889926369 cites W2013729223 @default.
• W1889926369 cites W2017560084 @default.
• W1889926369 cites W2018289835 @default.
• W1889926369 cites W2025340997 @default.
• W1889926369 cites W2027603959 @default.
• W1889926369 cites W2035016671 @default.
• W1889926369 cites W2037491928 @default.
• W1889926369 cites W2039610291 @default.
• W1889926369 cites W2047070443 @default.
• W1889926369 cites W2049858393 @default.
• W1889926369 cites W2052692052 @default.
• W1889926369 cites W2057902888 @default.
• W1889926369 cites W2062483982 @default.
• W1889926369 cites W2063450941 @default.
• W1889926369 cites W2064529356 @default.
• W1889926369 cites W2064883409 @default.
• W1889926369 cites W2086280546 @default.
• W1889926369 cites W2089396478 @default.
• W1889926369 cites W2100837269 @default.
• W1889926369 cites W2135380694 @default.
• W1889926369 cites W2137105424 @default.
• W1889926369 cites W2180795626 @default.
• W1889926369 cites W2261356028 @default.
• W1889926369 doi "https://doi.org/10.1128/jvi.55.2.314-321.1985" @default.
• W1889926369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/254935" @default.
• W1889926369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2991557" @default.
• W1889926369 hasPublicationYear "1985" @default.
• W1889926369 type Work @default.
• W1889926369 sameAs 1889926369 @default.
• W1889926369 citedByCount "52" @default.
• W1889926369 countsByYear W18899263692016 @default.
• W1889926369 countsByYear W18899263692020 @default.
• W1889926369 crossrefType "journal-article" @default.
• W1889926369 hasAuthorship W1889926369A5019699752 @default.
• W1889926369 hasAuthorship W1889926369A5055474312 @default.
• W1889926369 hasAuthorship W1889926369A5081166831 @default.
• W1889926369 hasBestOaLocation W18899263691 @default.
• W1889926369 hasConcept C104317684 @default.
• W1889926369 hasConcept C108636557 @default.
• W1889926369 hasConcept C11960822 @default.
• W1889926369 hasConcept C143065580 @default.
• W1889926369 hasConcept C150109051 @default.
• W1889926369 hasConcept C153911025 @default.
• W1889926369 hasConcept C167625842 @default.
• W1889926369 hasConcept C196347352 @default.
• W1889926369 hasConcept C2777441520 @default.
• W1889926369 hasConcept C54009773 @default.
• W1889926369 hasConcept C55493867 @default.
• W1889926369 hasConcept C86803240 @default.
• W1889926369 hasConcept C97029542 @default.
• W1889926369 hasConceptScore W1889926369C104317684 @default.
• W1889926369 hasConceptScore W1889926369C108636557 @default.
• W1889926369 hasConceptScore W1889926369C11960822 @default.
• W1889926369 hasConceptScore W1889926369C143065580 @default.
• W1889926369 hasConceptScore W1889926369C150109051 @default.
• W1889926369 hasConceptScore W1889926369C153911025 @default.
• W1889926369 hasConceptScore W1889926369C167625842 @default.
• W1889926369 hasConceptScore W1889926369C196347352 @default.
• W1889926369 hasConceptScore W1889926369C2777441520 @default.
• W1889926369 hasConceptScore W1889926369C54009773 @default.

• next