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- W1890105955 endingPage "e0125745" @default.
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- W1890105955 abstract "Growing evidence suggests a key role for RNA binding proteins (RBPs) in genome stability programs. Additionally, recent developments in RNA sequencing technologies, as well as mass-spectrometry techniques, have greatly expanded our knowledge on protein-RNA interactions. We here use full transcriptome sequencing and label-free LC/MS/MS to identify global changes in protein-RNA interactions in response to etoposide-induced genotoxic stress. We show that RBPs have distinct binding patterns in response to genotoxic stress and that inactivation of the RBP regulator module, p38/MK2, can affect the entire spectrum of protein-RNA interactions that take place in response to stress. In addition to validating the role of known RBPs like Srsf1, Srsf2, Elavl1 in the genotoxic stress response, we add a new collection of RBPs to the DNA damage response. We identify Khsrp as a highly regulated RBP in response to genotoxic stress and further validate its role as a driver of the G(1/)S transition through the suppression of Cdkn1a(P21) transcripts. Finally, we identify KHSRP as an indicator of overall survival, as well as disease free survival in glioblastoma multiforme." @default.
- W1890105955 created "2016-06-24" @default.
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- W1890105955 date "2015-05-20" @default.
- W1890105955 modified "2023-10-13" @default.
- W1890105955 title "Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression" @default.
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- W1890105955 doi "https://doi.org/10.1371/journal.pone.0125745" @default.
- W1890105955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4439058" @default.
- W1890105955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25993413" @default.
- W1890105955 hasPublicationYear "2015" @default.
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