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- W189065984 abstract "In recent years, the chemokine receptor CXCR4 has been shown to be implemented in the mobilization of progenitor cells from the bone marrow. This finding has prompted a search for CXCR4 antagonists acting as stem cell mobilizing agents. In accordance, it is important to look into the molecular pharmacology of well-known CXCR4 antagonists in order to augment the potency and affinity and to increase the specificity of future CXCR4-targeting compounds. In this chapter, binding modes of CXCR4 antagonists that have been shown to mobilize stem cells are discussed. In addition, comparisons between results obtained from structure–function studies and findings from newly released crystal structures are drawn." @default.
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- W189065984 date "2011-12-20" @default.
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- W189065984 title "Molecular Pharmacology of CXCR4 Inhibition" @default.
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- W189065984 doi "https://doi.org/10.1007/978-1-4614-1960-0_2" @default.
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