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- W1890758967 abstract "Small heterodimer partner (SHP; NR0B2) is a unique orphan nuclear receptor (NR) that contains a putative ligand-binding domain but lacks a DNA-binding domain. SHP is a transcriptional corepressor affecting diverse metabolic processes including bile acid synthesis, cholesterol and lipid metabolism, glucose and energy homeostasis, and reproductive biology via interaction with multiple NRs and transcriptional factors (TFs). Hepatocellular carcinoma (HCC) is one of the most deadly human cancers worldwide with few therapeutic options and poor prognosis. Recently, it is becoming clear that SHP plays an antitumor role in the development of liver cancer. In this review, we summarize the most recent findings regarding the new SHP interaction partners, new structural insights into SHP's gene repressing activity, and SHP protein posttranslational modifications by bile acids. We also discuss the pleiotropic role of SHP in regulating cell proliferation, apoptosis, DNA methylation, and inflammation that are related to antitumor role of SHP in HCC. Improving our understanding of SHP's antitumor role in the development of liver cancer will provide new insights into developing novel treatments or prevention strategies. Future research will focus on developing more efficacious and specific synthetic SHP ligands for pharmaceutical applications in liver cancer and several metabolic diseases such as hypercholesterolemia, obesity, diabetes, and fatty liver disease." @default.
- W1890758967 created "2016-06-24" @default.
- W1890758967 creator A5004376157 @default.
- W1890758967 creator A5006240342 @default.
- W1890758967 creator A5014488169 @default.
- W1890758967 creator A5076923264 @default.
- W1890758967 date "2015-01-01" @default.
- W1890758967 modified "2023-09-26" @default.
- W1890758967 title "New Insights into Orphan Nuclear Receptor SHP in Liver Cancer" @default.
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- W1890758967 cites W1967942094 @default.
- W1890758967 cites W1970048221 @default.
- W1890758967 cites W1970740746 @default.
- W1890758967 cites W1972829847 @default.
- W1890758967 cites W1977548456 @default.
- W1890758967 cites W1981095089 @default.
- W1890758967 cites W1982059385 @default.
- W1890758967 cites W1983057459 @default.
- W1890758967 cites W1983412315 @default.
- W1890758967 cites W1989421786 @default.
- W1890758967 cites W1990819179 @default.
- W1890758967 cites W1995501999 @default.
- W1890758967 cites W1996740401 @default.
- W1890758967 cites W1999677104 @default.
- W1890758967 cites W2008138667 @default.
- W1890758967 cites W2011295923 @default.
- W1890758967 cites W2012294080 @default.
- W1890758967 cites W2023980130 @default.
- W1890758967 cites W2031951464 @default.
- W1890758967 cites W2034992482 @default.
- W1890758967 cites W2035911481 @default.
- W1890758967 cites W2038279322 @default.
- W1890758967 cites W2039057187 @default.
- W1890758967 cites W2041012357 @default.
- W1890758967 cites W2045380897 @default.
- W1890758967 cites W2045958351 @default.
- W1890758967 cites W2046880375 @default.
- W1890758967 cites W2049655058 @default.
- W1890758967 cites W2055911345 @default.
- W1890758967 cites W2056365100 @default.
- W1890758967 cites W2058690999 @default.
- W1890758967 cites W2061357909 @default.
- W1890758967 cites W2068458442 @default.
- W1890758967 cites W2070428103 @default.
- W1890758967 cites W2073719082 @default.
- W1890758967 cites W2074624862 @default.
- W1890758967 cites W2078810890 @default.
- W1890758967 cites W2080281787 @default.
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- W1890758967 cites W2123667080 @default.
- W1890758967 cites W2124343538 @default.
- W1890758967 cites W2124775971 @default.
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- W1890758967 cites W2148672071 @default.
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- W1890758967 cites W2166235215 @default.
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- W1890758967 cites W2172132693 @default.
- W1890758967 cites W2324384090 @default.
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- W1890758967 doi "https://doi.org/10.11131/2015/101162" @default.
- W1890758967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618403" @default.
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- W1890758967 hasPublicationYear "2015" @default.
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