FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W189088503> ?p ?o ?g. }

• W189088503 endingPage "430" @default.
• W189088503 startingPage "430" @default.
• W189088503 abstract "Background: Cardiac progenitor cell transfer may improve myocardial repair after acute myocardial infarction (AMI), but responsible cell types and mechanisms remain uncertain. Methods: In a blinded, randomized, controlled study, we infused allogeneic porcine LentiGFP-infected mesenchymal stem cells (MSC, n=11, 10±2x10 6 CD29 – 44 –90 cells, capable of adipogenic and osteogenic differentiation), autologous late-outgrowth endothelial progenitor cells (EPC, n=10, 34±22x10 6 CD29 –31 cells, capable of tube formation) or vehicle (CON, n=10) in the CX artery 1 w after AMI induced by 90 min balloon occlusion. Hemodynamic and cine MRI measurements (dP/dt max/min and ejection fraction, EF) were performed at 1w and 7w follow-up. We measured LV remodeling from end-diastolic and end-systolic volumes (EDV, ESV) and quantified infarct size and transmurality on late enhanced images. We evaluated the secretome of cultured EPC and MSC and compared changes in relative upslope (RU) of first-pass perfusion images and vascular density on postmortem sections from infarct core and border zones. Results: While systolic function (dP/dt max/min and EF) at 7 w was similar between groups, LVEDV increased in MSC and CON pigs, but not in EPC pigs [+23.3 (25–75 th percentile 1.7;27.9) and +26 ml/m 2 (17.9;31.9) vs +0.8 ml/m 2 (−10.1;18.8), resp, P 2 (5.9;14.5) in MSC and CON, resp], vs −1.8 ml/m 2 (−13.5;0.7) in EPC ( P =0.06). After EPC transfer, infarct size decreased more in segments with >50% infarct transmurality ( P =0.01 vs MSC and CON). Myocardial perfusion increased more in EPC than in MSC and CON [RU +72% (−2;119) vs −2% (−28;84) and +25% (−33;236), resp], and was associated with greater vascular density in infarct border zones ( P =0.01) and with higher levels of pro-angiogenic growth factors, PLGF and FGF2 in EPC secretome (1730±1002 and 75±44 pg/10 6 cells resp vs 73±16 and 19±12 in MSC secretome,,n=5). No evidence of cell transdifferentiation was observed at 7w. Conclusion: Infusion of late-outgrowth EPCs after AMI limits negative LV remodeling but does not mediate cardiomyogenesis. EPC transfer may hold promise for heart failure prevention via paracrine matrix-modulating or pro-angiogenic effects." @default.
• W189088503 created "2016-06-24" @default.
• W189088503 creator A5004855849 @default.
• W189088503 creator A5014806250 @default.
• W189088503 creator A5016770191 @default.
• W189088503 creator A5026432849 @default.
• W189088503 creator A5028548769 @default.
• W189088503 creator A5035651557 @default.
• W189088503 creator A5038783310 @default.
• W189088503 creator A5044014184 @default.
• W189088503 creator A5046208454 @default.
• W189088503 creator A5054557179 @default.
• W189088503 creator A5055887513 @default.
• W189088503 creator A5061687360 @default.
• W189088503 creator A5070495078 @default.
• W189088503 creator A5072028836 @default.
• W189088503 creator A5072529198 @default.
• W189088503 creator A5091108531 @default.
• W189088503 date "2008-10-28" @default.
• W189088503 modified "2023-10-18" @default.
• W189088503 title "Differential Effects of Progenitor Cell Populations on Myocardial Neovascularization and Left Ventricular Remodeling after Myocardial Infarction" @default.
• W189088503 hasPublicationYear "2008" @default.
• W189088503 type Work @default.
• W189088503 sameAs 189088503 @default.
• W189088503 citedByCount "0" @default.
• W189088503 crossrefType "journal-article" @default.
• W189088503 hasAuthorship W189088503A5004855849 @default.
• W189088503 hasAuthorship W189088503A5014806250 @default.
• W189088503 hasAuthorship W189088503A5016770191 @default.
• W189088503 hasAuthorship W189088503A5026432849 @default.
• W189088503 hasAuthorship W189088503A5028548769 @default.
• W189088503 hasAuthorship W189088503A5035651557 @default.
• W189088503 hasAuthorship W189088503A5038783310 @default.
• W189088503 hasAuthorship W189088503A5044014184 @default.
• W189088503 hasAuthorship W189088503A5046208454 @default.
• W189088503 hasAuthorship W189088503A5054557179 @default.
• W189088503 hasAuthorship W189088503A5055887513 @default.
• W189088503 hasAuthorship W189088503A5061687360 @default.
• W189088503 hasAuthorship W189088503A5070495078 @default.
• W189088503 hasAuthorship W189088503A5072028836 @default.
• W189088503 hasAuthorship W189088503A5072529198 @default.
• W189088503 hasAuthorship W189088503A5091108531 @default.
• W189088503 hasConcept C126322002 @default.
• W189088503 hasConcept C142724271 @default.
• W189088503 hasConcept C146957229 @default.
• W189088503 hasConcept C164705383 @default.
• W189088503 hasConcept C198826908 @default.
• W189088503 hasConcept C201750760 @default.
• W189088503 hasConcept C2777408375 @default.
• W189088503 hasConcept C2778198053 @default.
• W189088503 hasConcept C2778271429 @default.
• W189088503 hasConcept C2779537366 @default.
• W189088503 hasConcept C2780152582 @default.
• W189088503 hasConcept C2780394083 @default.
• W189088503 hasConcept C28328180 @default.
• W189088503 hasConcept C500558357 @default.
• W189088503 hasConcept C54355233 @default.
• W189088503 hasConcept C71924100 @default.
• W189088503 hasConcept C78085059 @default.
• W189088503 hasConcept C86803240 @default.
• W189088503 hasConceptScore W189088503C126322002 @default.
• W189088503 hasConceptScore W189088503C142724271 @default.
• W189088503 hasConceptScore W189088503C146957229 @default.
• W189088503 hasConceptScore W189088503C164705383 @default.
• W189088503 hasConceptScore W189088503C198826908 @default.
• W189088503 hasConceptScore W189088503C201750760 @default.
• W189088503 hasConceptScore W189088503C2777408375 @default.
• W189088503 hasConceptScore W189088503C2778198053 @default.
• W189088503 hasConceptScore W189088503C2778271429 @default.
• W189088503 hasConceptScore W189088503C2779537366 @default.
• W189088503 hasConceptScore W189088503C2780152582 @default.
• W189088503 hasConceptScore W189088503C2780394083 @default.
• W189088503 hasConceptScore W189088503C28328180 @default.
• W189088503 hasConceptScore W189088503C500558357 @default.
• W189088503 hasConceptScore W189088503C54355233 @default.
• W189088503 hasConceptScore W189088503C71924100 @default.
• W189088503 hasConceptScore W189088503C78085059 @default.
• W189088503 hasConceptScore W189088503C86803240 @default.
• W189088503 hasIssue "18" @default.
• W189088503 hasLocation W1890885031 @default.
• W189088503 hasOpenAccess W189088503 @default.
• W189088503 hasPrimaryLocation W1890885031 @default.
• W189088503 hasRelatedWork W1976326232 @default.
• W189088503 hasRelatedWork W2005564264 @default.
• W189088503 hasRelatedWork W2018619273 @default.
• W189088503 hasRelatedWork W2020647534 @default.
• W189088503 hasRelatedWork W2047860843 @default.
• W189088503 hasRelatedWork W2049694903 @default.
• W189088503 hasRelatedWork W2053595149 @default.
• W189088503 hasRelatedWork W2066861020 @default.
• W189088503 hasRelatedWork W2074463920 @default.
• W189088503 hasRelatedWork W2080097356 @default.
• W189088503 hasRelatedWork W2086316501 @default.
• W189088503 hasRelatedWork W2102901871 @default.
• W189088503 hasRelatedWork W2110462638 @default.
• W189088503 hasRelatedWork W2139234903 @default.
• W189088503 hasRelatedWork W2252420734 @default.
• W189088503 hasRelatedWork W2281510048 @default.

• next