FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1890939242> ?p ?o ?g. }

• W1890939242 endingPage "e0130099" @default.
• W1890939242 startingPage "e0130099" @default.
• W1890939242 abstract "The flagellar pocket constitutes an active and strategic site in the body of trypanosomatids (i.e. parasitic protozoa that cause important human and/or livestock diseases), which participates in several important processes such as cell polarity, morphogenesis and replication. Most importantly, the flagellar pocket is the unique site of surface protein export and nutrient uptake in trypanosomatids, and thus constitutes a key portal for the interaction with the host. In this work, we identified and characterized a novel Trypanosoma cruzi protein, termed TCLP 1, that accumulates at the flagellar pocket area of parasite replicative forms, as revealed by biochemical, immuno-cytochemistry and electron microscopy techniques. Different in silico analyses revealed that TCLP 1 is the founding member of a family of chimeric molecules restricted to trypanosomatids bearing, in addition to eukaryotic ubiquitin-like and protein-protein interacting domains, a motif displaying significant structural homology to bacterial multi-cargo chaperones involved in the secretion of virulence factors. Using the fidelity of an homologous expression system we confirmed TCLP 1 sub-cellular distribution and showed that TCLP 1-over-expressing parasites display impaired survival and accelerated progression to late stationary phase under starvation conditions. The reduced endocytic capacity of TCLP 1-over-expressors likely underlies (at least in part) this growth phenotype. TCLP 1 is involved in the uptake of extracellular macromolecules required for nutrition and hence in T. cruzi growth. Due to the bacterial origin, sub-cellular distribution and putative function(s), we propose TCLP 1 and related orthologs in trypanosomatids as appealing therapeutic targets for intervention against these health-threatening parasites." @default.
• W1890939242 created "2016-06-24" @default.
• W1890939242 creator A5001494761 @default.
• W1890939242 creator A5073936466 @default.
• W1890939242 creator A5074266529 @default.
• W1890939242 date "2015-06-18" @default.
• W1890939242 modified "2023-10-03" @default.
• W1890939242 title "A Novel Trypanosoma cruzi Protein Associated to the Flagellar Pocket of Replicative Stages and Involved in Parasite Growth" @default.
• W1890939242 cites W1508733931 @default.
• W1890939242 cites W1524666565 @default.
• W1890939242 cites W1577035833 @default.
• W1890939242 cites W181468314 @default.
• W1890939242 cites W1915912984 @default.
• W1890939242 cites W1933230950 @default.
• W1890939242 cites W1939117002 @default.
• W1890939242 cites W1956942917 @default.
• W1890939242 cites W1958696553 @default.
• W1890939242 cites W1963957860 @default.
• W1890939242 cites W1967856260 @default.
• W1890939242 cites W1973149124 @default.
• W1890939242 cites W1975055427 @default.
• W1890939242 cites W1977527571 @default.
• W1890939242 cites W1987356771 @default.
• W1890939242 cites W1987704449 @default.
• W1890939242 cites W1995498227 @default.
• W1890939242 cites W1996085556 @default.
• W1890939242 cites W1996518652 @default.
• W1890939242 cites W1998626269 @default.
• W1890939242 cites W2002994706 @default.
• W1890939242 cites W2003359585 @default.
• W1890939242 cites W2004798786 @default.
• W1890939242 cites W2007731694 @default.
• W1890939242 cites W2013465778 @default.
• W1890939242 cites W2013913567 @default.
• W1890939242 cites W2019461837 @default.
• W1890939242 cites W2020966544 @default.
• W1890939242 cites W2025277548 @default.
• W1890939242 cites W2027713759 @default.
• W1890939242 cites W2028356785 @default.
• W1890939242 cites W2028845802 @default.
• W1890939242 cites W2036388292 @default.
• W1890939242 cites W2043690247 @default.
• W1890939242 cites W2045504198 @default.
• W1890939242 cites W2045594331 @default.
• W1890939242 cites W2046068908 @default.
• W1890939242 cites W2051915138 @default.
• W1890939242 cites W2058619154 @default.
• W1890939242 cites W2070026868 @default.
• W1890939242 cites W2071539516 @default.
• W1890939242 cites W2072340281 @default.
• W1890939242 cites W2084500816 @default.
• W1890939242 cites W2087860032 @default.
• W1890939242 cites W2093251234 @default.
• W1890939242 cites W2101484541 @default.
• W1890939242 cites W2105006060 @default.
• W1890939242 cites W2107762253 @default.
• W1890939242 cites W2112800304 @default.
• W1890939242 cites W2119509367 @default.
• W1890939242 cites W2124297330 @default.
• W1890939242 cites W2124519714 @default.
• W1890939242 cites W2124769246 @default.
• W1890939242 cites W2130060890 @default.
• W1890939242 cites W2131228709 @default.
• W1890939242 cites W2131907967 @default.
• W1890939242 cites W2132926880 @default.
• W1890939242 cites W2133987610 @default.
• W1890939242 cites W2134810533 @default.
• W1890939242 cites W2143859954 @default.
• W1890939242 cites W2144565250 @default.
• W1890939242 cites W2147592143 @default.
• W1890939242 cites W2149024161 @default.
• W1890939242 cites W2152301430 @default.
• W1890939242 cites W2158427156 @default.
• W1890939242 cites W2159614853 @default.
• W1890939242 cites W2163005000 @default.
• W1890939242 cites W2167630461 @default.
• W1890939242 cites W2169030979 @default.
• W1890939242 cites W2169665346 @default.
• W1890939242 cites W2189532371 @default.
• W1890939242 cites W2292320336 @default.
• W1890939242 cites W4378951057 @default.
• W1890939242 cites W2029284410 @default.
• W1890939242 doi "https://doi.org/10.1371/journal.pone.0130099" @default.
• W1890939242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4472858" @default.
• W1890939242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26086767" @default.
• W1890939242 hasPublicationYear "2015" @default.
• W1890939242 type Work @default.
• W1890939242 sameAs 1890939242 @default.
• W1890939242 citedByCount "9" @default.
• W1890939242 countsByYear W18909392422016 @default.
• W1890939242 countsByYear W18909392422017 @default.
• W1890939242 countsByYear W18909392422019 @default.
• W1890939242 countsByYear W18909392422020 @default.
• W1890939242 countsByYear W18909392422022 @default.
• W1890939242 crossrefType "journal-article" @default.
• W1890939242 hasAuthorship W1890939242A5001494761 @default.
• W1890939242 hasAuthorship W1890939242A5073936466 @default.
• W1890939242 hasAuthorship W1890939242A5074266529 @default.

• next