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- W1890954725 abstract "The epsilon-globin gene is the first of the human beta-like globin genes to be expressed during development. We have analyzed protein-DNA interactions in the epsilon-globin promoter region by DNase I footprinting and electrophoretic mobility shift experiments using nuclear extracts from K562 human erythroid cells and from nonerythroid HeLa cells. A restricted set of ubiquitous proteins, including Sp1, bound to regions of the promoter including the CACCC and CCAAT sites. Three interactions, at positions -213, -165, and +3 relative to the transcription start site, were erythroid specific and corresponded to binding of GATA-1, a transcription factor highly restricted to the erythroid lineage. Interestingly, the GATA-1 site at -165 has been conserved in the promoters of 10 mammalian embryonic globin genes. Point mutations demonstrate that GATA-1 binding to this site is necessary for interaction with an erythroid-specific enhancer but that in the absence of an enhancer, GATA-1 does not increase transcription." @default.
- W1890954725 created "2016-06-24" @default.
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- W1890954725 date "1991-05-01" @default.
- W1890954725 modified "2023-10-16" @default.
- W1890954725 title "Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter." @default.
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- W1890954725 doi "https://doi.org/10.1128/mcb.11.5.2558" @default.
- W1890954725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/360025" @default.
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