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- W1891275484 abstract "Parkinson's disease, the most common neurological disorder in the elderly, is characterized by progressive extrapyramidal motor dysfunction including resting tremors, muscle rigidity, hypolocomotion (bradykinesia and akinesia) and postural instability. Various non-motor features are also seen such as cognitive impairments (deficits in learning and memory) and mood disorders (depression and anxiety). While the 5-HT(1A) receptor has long been implicated in the pathogenesis and treatment of anxiety and depression, recent research has revealed new therapeutic roles for 5-HT(1A) receptors in the treatment of Parkinson's disease. These include the modulation of parkinsonian motor symptoms, L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia, cognitive impairments and emesis. Thus, 5-HT(1A) agonists improve the various motor disorders associated with dopaminergic deficits, dyskinesia induced by chronic L-DOPA treatment, mood disturbances (anxiety and depression) and dopamine agonist-induced emesis. In addition, partial 5-HT(1A) agonists are expected to improve cognitive impairment in Parkinson's patients. These findings encourage research into new 5-HT(1A) receptor ligands, which will improve efficacy and/or ameliorate adverse reactions in the treatment of Parkinson's disease." @default.
- W1891275484 created "2016-06-24" @default.
- W1891275484 creator A5013647008 @default.
- W1891275484 creator A5050238592 @default.
- W1891275484 date "2013-02-01" @default.
- W1891275484 modified "2023-09-23" @default.
- W1891275484 title "Improving the Treatment of Parkinson's Disease: A Novel Approach by Modulating 5-HT(1A) Receptors." @default.
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- W1891275484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3570136" @default.
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- W1891275484 hasPublicationYear "2013" @default.
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