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- W189147310 abstract "1218 Objectives To evaluate the PBR ligand [11C]SSR180575 in an acute and chronic model for neuroinflammation as compared to the reference [11C]PK11195. Methods SSR180575 was labeled with carbon-11. For acute and chronic neuroinflammation we used respectively the AMPA rat model (n=14) (Boutin JNM 2007) and double transgenic mice (APP×PS1, n=15) for Alzheimer’s disease at the age of 12 months. All animals were scanned using the Concorde Focus 220 µPET scanner. Both rat and mouse models were divided in 4 equal groups to study the brain kinetics of [11C]PK11195 and [11C]SSR180575, and the specificity of the binding by displacement studies using an excess (1 mg/kg) of non-labeled PK11195 or SSR180575. Additional to in vivo studies we performed in vitro autoradiography on the same models. Results In rats, the uptake ratio of [11C]SSR180575 in the lesioned-over intact striatum was significantly higher for [11C]SSR180575 than [11C]PK11195. Competition with PK11195 or SSR180575 quickly displaced the tracer from the lesioned side. Autoradiography on brain sections confirmed the in vivo results with a high ipsi- to contralateral ratio (3.8), which was abolished by an excess of PK11195 or SSR180575. In both PS1 and APPxPS1 mice, [11C]SSR180575 uptake in the whole brain was higher as compared to the uptake of [11C]PK11195. In addition, in vitro autoradiography showed high specific binding in APPxPS1 mice that was double the binding of PS1 mice. Conclusions The results obtained confirm the potential of [11C]SSR180575 to image neuroinflammation." @default.
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- W189147310 date "2009-05-01" @default.
- W189147310 modified "2023-10-15" @default.
- W189147310 title "[11C]SSR180575: Preliminary evaluation in rodent models of neuroinflammation" @default.
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