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- W1891881566 abstract "Heterotrimeric GTP binding proteins (G proteins) mediate signal generated by neurotransmitter and hormones. Among all G proteins, Go is the most abundant in brain but its role in brain is not clearly understood. To determine the function of the alpha subunit of Go (Goα), we search for the interacting partner of Goα in brain using yeast two-hybrid system. A resistant to inhibitor of cholinesterase (Ric-8B) was identified as a Goα interacting protein. We confirmed interaction between Goα and Ric-8b employing in vitro affinity binding assay and showed that the Ric-8b increased the function of Goα. Our findings indicate that Ric-8b is possible guanine nucleotide exchange factor for Goα." @default.
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- W1891881566 date "2007-06-01" @default.
- W1891881566 modified "2023-09-24" @default.
- W1891881566 title "Ric-8B Modulates the Function of Alpha Subunit of Go" @default.
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- W1891881566 hasPublicationYear "2007" @default.
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