FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1891997222> ?p ?o ?g. }

• W1891997222 endingPage "1252" @default.
• W1891997222 startingPage "1247" @default.
• W1891997222 abstract "Abstract Background. The incidence of anal carcinoma in the U.S. continues to increase steadily, and infection with the human papillomavirus (HPV) is an established risk factor for the development of anal carcinoma. However, the clinicopathologic characteristics of patients with metastatic squamous cell carcinoma of the anal canal according to HPV status have not yet been defined. Materials and Methods. The records of patients treated for metastatic squamous cell carcinoma of the anal canal at the MD Anderson Cancer Center from June 2005 to August 2013 were reviewed. The patients were tested for the presence of HPV DNA by in situ hybridization and/or the p16 oncoprotein by immunohistochemistry. Associations between the presence of HPV and clinicopathologic attributes were measured. Results. Of the 72 patients reviewed, 68 tumors (94%) had detectable HPV. Patients with HPV-negative tumors were more likely to be of nonwhite ethnicity (odds ratio, 8.7) and have a strong (&gt;30 pack-year) tobacco history (odds ratio, 8.7). A trend toward improved survival from the time of diagnosis of metastatic disease was noted among patients with HPV-positive tumors. Conclusion. Most patients with metastatic anal cancer had detectable HPV, with differences in tobacco history and ethnicity detected according to HPV status. The high frequency of HPV positivity for patients with metastatic anal cancer has important implications for novel immunotherapy treatment approaches, including ongoing clinical trials with immune checkpoint blockade agents using antibodies targeting the programmed death-1 receptor. Implications for Practice: Previous studies investigating the clinical features of patients with anal cancer focused on those with early-stage disease. The present study characterizes, for the first time, clinical and pathological features according to human papillomavirus (HPV) status for patients with metastatic anal cancer. A high frequency of HPV-positive tumors and correlations between HPV status and both ethnicity and tobacco history was found. No standard-of-care therapy is available for patients with metastatic anal cancer, and most receive cytotoxic chemotherapy. The high prevalence of HPV in the current population generates optimism for ongoing clinical trials investigating the role of immune checkpoint blockade agents as a novel treatment approach for this disease." @default.
• W1891997222 created "2016-06-24" @default.
• W1891997222 creator A5009132832 @default.
• W1891997222 creator A5010668711 @default.
• W1891997222 creator A5013187820 @default.
• W1891997222 creator A5016694714 @default.
• W1891997222 creator A5034037126 @default.
• W1891997222 creator A5035371911 @default.
• W1891997222 creator A5050429899 @default.
• W1891997222 creator A5080692116 @default.
• W1891997222 creator A5082668053 @default.
• W1891997222 creator A5088389768 @default.
• W1891997222 date "2015-09-17" @default.
• W1891997222 modified "2023-09-24" @default.
• W1891997222 title "Clinicopathologic Features Associated With Human Papillomavirus/p16 in Patients With Metastatic Squamous Cell Carcinoma of the Anal Canal" @default.
• W1891997222 cites W1482866244 @default.
• W1891997222 cites W1620032110 @default.
• W1891997222 cites W1804130247 @default.
• W1891997222 cites W1938171108 @default.
• W1891997222 cites W1947979503 @default.
• W1891997222 cites W1972191022 @default.
• W1891997222 cites W1977129112 @default.
• W1891997222 cites W1981725818 @default.
• W1891997222 cites W1983052612 @default.
• W1891997222 cites W1985213644 @default.
• W1891997222 cites W1985233123 @default.
• W1891997222 cites W1994238092 @default.
• W1891997222 cites W1998345145 @default.
• W1891997222 cites W2008750108 @default.
• W1891997222 cites W2013639959 @default.
• W1891997222 cites W2018098593 @default.
• W1891997222 cites W2039382131 @default.
• W1891997222 cites W2041176483 @default.
• W1891997222 cites W2045332034 @default.
• W1891997222 cites W2050320008 @default.
• W1891997222 cites W2060786724 @default.
• W1891997222 cites W2063806298 @default.
• W1891997222 cites W2068081619 @default.
• W1891997222 cites W2068334303 @default.
• W1891997222 cites W2075791450 @default.
• W1891997222 cites W2079296486 @default.
• W1891997222 cites W2083262432 @default.
• W1891997222 cites W2083807892 @default.
• W1891997222 cites W2086226963 @default.
• W1891997222 cites W2091286208 @default.
• W1891997222 cites W2096733107 @default.
• W1891997222 cites W2101838057 @default.
• W1891997222 cites W2110664940 @default.
• W1891997222 cites W2123526038 @default.
• W1891997222 cites W2127605299 @default.
• W1891997222 cites W2128978912 @default.
• W1891997222 cites W2131971625 @default.
• W1891997222 cites W2133636335 @default.
• W1891997222 cites W2141274038 @default.
• W1891997222 cites W2145150089 @default.
• W1891997222 cites W2146906100 @default.
• W1891997222 cites W2149166037 @default.
• W1891997222 cites W2153043270 @default.
• W1891997222 cites W2170552969 @default.
• W1891997222 cites W2407851486 @default.
• W1891997222 cites W2560367415 @default.
• W1891997222 cites W2597872842 @default.
• W1891997222 cites W2916008418 @default.
• W1891997222 cites W3150552852 @default.
• W1891997222 cites W4232048942 @default.
• W1891997222 doi "https://doi.org/10.1634/theoncologist.2015-0091" @default.
• W1891997222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4718442" @default.
• W1891997222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26382740" @default.
• W1891997222 hasPublicationYear "2015" @default.
• W1891997222 type Work @default.
• W1891997222 sameAs 1891997222 @default.
• W1891997222 citedByCount "27" @default.
• W1891997222 countsByYear W18919972222016 @default.
• W1891997222 countsByYear W18919972222017 @default.
• W1891997222 countsByYear W18919972222018 @default.
• W1891997222 countsByYear W18919972222019 @default.
• W1891997222 countsByYear W18919972222020 @default.
• W1891997222 countsByYear W18919972222021 @default.
• W1891997222 countsByYear W18919972222022 @default.
• W1891997222 crossrefType "journal-article" @default.
• W1891997222 hasAuthorship W1891997222A5009132832 @default.
• W1891997222 hasAuthorship W1891997222A5010668711 @default.
• W1891997222 hasAuthorship W1891997222A5013187820 @default.
• W1891997222 hasAuthorship W1891997222A5016694714 @default.
• W1891997222 hasAuthorship W1891997222A5034037126 @default.
• W1891997222 hasAuthorship W1891997222A5035371911 @default.
• W1891997222 hasAuthorship W1891997222A5050429899 @default.
• W1891997222 hasAuthorship W1891997222A5080692116 @default.
• W1891997222 hasAuthorship W1891997222A5082668053 @default.
• W1891997222 hasAuthorship W1891997222A5088389768 @default.
• W1891997222 hasBestOaLocation W18919972221 @default.
• W1891997222 hasConcept C120665830 @default.
• W1891997222 hasConcept C121332964 @default.
• W1891997222 hasConcept C121608353 @default.
• W1891997222 hasConcept C126322002 @default.
• W1891997222 hasConcept C143998085 @default.
• W1891997222 hasConcept C156957248 @default.
• W1891997222 hasConcept C2779840525 @default.

• next