Matches in SemOpenAlex for { <https://semopenalex.org/work/W1891998632> ?p ?o ?g. }
- W1891998632 endingPage "300" @default.
- W1891998632 startingPage "288" @default.
- W1891998632 abstract "Understanding of the role of estrogen receptors (ERα and ERβ) in the pathophysiology of breast cancer (BC) has considerably increased in last decades. Despite sharing a similar structure, these two transcription factors often exert opposite roles in BC. In addition, it has been shown that their transcriptional activity is not strictly associated to ligand activation and that unliganded ERs are able to have a life on their own. This appears to be mainly due to ligand-independent mechanisms leading to ERs PTMs or to their recruitment to specific protein complexes, dependent on cellular context. Furthermore, a significant unliganded ER activity, probably independent by the activation of other pathways, has been recently reported to affect gene transcription, microRNA expression, and downstream proteome. In this review, we describe recent findings on nuclear and cytoplasmic unliganded ERα and ERβ activity. We focus on functional genomics, epigenomics, and interaction proteomics data, including PTM induced by ERs-modulated miRNAs in the BC context. A better comprehension of the molecular events controlled by unliganded ERs activity in BC pathogenesis is crucial since it may impact the therapeutic approach to the initial or acquired resistance to endocrine therapies, frequently experienced in the treatment of BC." @default.
- W1891998632 created "2016-06-24" @default.
- W1891998632 creator A5009028518 @default.
- W1891998632 creator A5017584434 @default.
- W1891998632 creator A5028482826 @default.
- W1891998632 creator A5050045829 @default.
- W1891998632 creator A5076007006 @default.
- W1891998632 creator A5078787117 @default.
- W1891998632 date "2015-12-17" @default.
- W1891998632 modified "2023-09-30" @default.
- W1891998632 title "The “busy life” of unliganded estrogen receptors" @default.
- W1891998632 cites W1493770466 @default.
- W1891998632 cites W1537397007 @default.
- W1891998632 cites W1857981040 @default.
- W1891998632 cites W1963718035 @default.
- W1891998632 cites W1966878363 @default.
- W1891998632 cites W1973036877 @default.
- W1891998632 cites W1975046195 @default.
- W1891998632 cites W1979977994 @default.
- W1891998632 cites W1984469213 @default.
- W1891998632 cites W1985976602 @default.
- W1891998632 cites W1986285928 @default.
- W1891998632 cites W1989099841 @default.
- W1891998632 cites W1989698840 @default.
- W1891998632 cites W1994095991 @default.
- W1891998632 cites W1996722984 @default.
- W1891998632 cites W1996732665 @default.
- W1891998632 cites W1996909912 @default.
- W1891998632 cites W1997006452 @default.
- W1891998632 cites W1997622817 @default.
- W1891998632 cites W1998485305 @default.
- W1891998632 cites W1999191546 @default.
- W1891998632 cites W1999252671 @default.
- W1891998632 cites W2001377879 @default.
- W1891998632 cites W2006363105 @default.
- W1891998632 cites W2007819180 @default.
- W1891998632 cites W2009468514 @default.
- W1891998632 cites W2009680456 @default.
- W1891998632 cites W2010309484 @default.
- W1891998632 cites W2011540227 @default.
- W1891998632 cites W2012515613 @default.
- W1891998632 cites W2013642090 @default.
- W1891998632 cites W2016669417 @default.
- W1891998632 cites W2019198121 @default.
- W1891998632 cites W2021383412 @default.
- W1891998632 cites W2021713357 @default.
- W1891998632 cites W2021828774 @default.
- W1891998632 cites W2021880374 @default.
- W1891998632 cites W2024875989 @default.
- W1891998632 cites W2026637523 @default.
- W1891998632 cites W2027444207 @default.
- W1891998632 cites W2030394345 @default.
- W1891998632 cites W2031383572 @default.
- W1891998632 cites W2032153924 @default.
- W1891998632 cites W2033124645 @default.
- W1891998632 cites W2033672070 @default.
- W1891998632 cites W2034001757 @default.
- W1891998632 cites W2034329390 @default.
- W1891998632 cites W2035336181 @default.
- W1891998632 cites W2036001944 @default.
- W1891998632 cites W2036334064 @default.
- W1891998632 cites W2038250560 @default.
- W1891998632 cites W2039338696 @default.
- W1891998632 cites W2039576757 @default.
- W1891998632 cites W2053214239 @default.
- W1891998632 cites W2056550511 @default.
- W1891998632 cites W2058240476 @default.
- W1891998632 cites W2059384572 @default.
- W1891998632 cites W2061551473 @default.
- W1891998632 cites W2061674718 @default.
- W1891998632 cites W2067594036 @default.
- W1891998632 cites W2068205741 @default.
- W1891998632 cites W2072787342 @default.
- W1891998632 cites W2073353512 @default.
- W1891998632 cites W2074680809 @default.
- W1891998632 cites W2076524169 @default.
- W1891998632 cites W2079633900 @default.
- W1891998632 cites W2080158944 @default.
- W1891998632 cites W2080987913 @default.
- W1891998632 cites W2081357772 @default.
- W1891998632 cites W2083876166 @default.
- W1891998632 cites W2086407765 @default.
- W1891998632 cites W2088280645 @default.
- W1891998632 cites W2097246067 @default.
- W1891998632 cites W2103824461 @default.
- W1891998632 cites W2110430672 @default.
- W1891998632 cites W2112131993 @default.
- W1891998632 cites W2112816468 @default.
- W1891998632 cites W2117555991 @default.
- W1891998632 cites W2120137028 @default.
- W1891998632 cites W2121664015 @default.
- W1891998632 cites W2122994172 @default.
- W1891998632 cites W2123674503 @default.
- W1891998632 cites W2133010239 @default.
- W1891998632 cites W2134358258 @default.
- W1891998632 cites W2135060880 @default.
- W1891998632 cites W2137543869 @default.
- W1891998632 cites W2141631089 @default.