Matches in SemOpenAlex for { <https://semopenalex.org/work/W1892014909> ?p ?o ?g. }
- W1892014909 endingPage "337" @default.
- W1892014909 startingPage "328" @default.
- W1892014909 abstract "Invasive infection caused by Neisseria meningitidis is a worldwide public health problem. Previous reports have indicated that carriage of common ‘defective’ structural polymorphisms of the host mannose-binding lectin gene (MBL2) greatly increases an individual’s risk of developing the disease. We report the largest case–control study so far to investigate the effect of these polymorphisms in meningococcal disease (296 PCR-positive cases and 5196 population controls, all of European ancestry) and demonstrate that no change in risk is associated with the polymorphisms overall or in any age-defined subgroup. This finding contrasts with two smaller studies that reported an increase in risk. A systematic review of all studies of MBL2 polymorphisms in people of European ancestry published since 1999, including 24 693 individuals, revealed a population frequency of the combined ‘defective’MBL2 allele of 0.230 (95% confidence limits: 0.226–0.234). The past reported associations of increased risk of meningococcal disease were because of low ‘defective’ allele frequencies in their study control populations (0.13 and 0.04) that indicate systematic problems with the studies. The data from our study and all other available evidence indicate that MBL2 structural polymorphisms do not predispose children or adults to invasive meningococcal disease." @default.
- W1892014909 created "2016-06-24" @default.
- W1892014909 creator A5022420274 @default.
- W1892014909 creator A5033858904 @default.
- W1892014909 creator A5050042609 @default.
- W1892014909 creator A5067381987 @default.
- W1892014909 creator A5079602397 @default.
- W1892014909 creator A5080557082 @default.
- W1892014909 creator A5087398782 @default.
- W1892014909 creator A5087865591 @default.
- W1892014909 date "2012-02-02" @default.
- W1892014909 modified "2023-10-14" @default.
- W1892014909 title "Genetic susceptibility to invasive meningococcal disease: MBL2 structural polymorphisms revisited in a large case-control study and a systematic review" @default.
- W1892014909 cites W1494478165 @default.
- W1892014909 cites W1527004061 @default.
- W1892014909 cites W1554324835 @default.
- W1892014909 cites W1970372539 @default.
- W1892014909 cites W1980248442 @default.
- W1892014909 cites W1988365133 @default.
- W1892014909 cites W1989011168 @default.
- W1892014909 cites W1996814765 @default.
- W1892014909 cites W1999301355 @default.
- W1892014909 cites W2008834769 @default.
- W1892014909 cites W2011846108 @default.
- W1892014909 cites W2013863789 @default.
- W1892014909 cites W2015826900 @default.
- W1892014909 cites W2025613223 @default.
- W1892014909 cites W2030823247 @default.
- W1892014909 cites W2035438336 @default.
- W1892014909 cites W2037306042 @default.
- W1892014909 cites W2061248440 @default.
- W1892014909 cites W2070617252 @default.
- W1892014909 cites W2070618971 @default.
- W1892014909 cites W2070836718 @default.
- W1892014909 cites W2077008485 @default.
- W1892014909 cites W2082411276 @default.
- W1892014909 cites W2086382677 @default.
- W1892014909 cites W2087387372 @default.
- W1892014909 cites W2100840573 @default.
- W1892014909 cites W2102782864 @default.
- W1892014909 cites W2106759155 @default.
- W1892014909 cites W2107550468 @default.
- W1892014909 cites W2115422918 @default.
- W1892014909 cites W2120540945 @default.
- W1892014909 cites W2124517771 @default.
- W1892014909 cites W2132000476 @default.
- W1892014909 cites W2132497218 @default.
- W1892014909 cites W2136895332 @default.
- W1892014909 cites W2139409203 @default.
- W1892014909 cites W2143970440 @default.
- W1892014909 cites W2144495765 @default.
- W1892014909 cites W2145542662 @default.
- W1892014909 cites W2146970713 @default.
- W1892014909 cites W2148312531 @default.
- W1892014909 cites W2161633633 @default.
- W1892014909 cites W2164266195 @default.
- W1892014909 cites W2167802566 @default.
- W1892014909 cites W2169801019 @default.
- W1892014909 cites W2171120557 @default.
- W1892014909 cites W2395242869 @default.
- W1892014909 cites W3149910839 @default.
- W1892014909 doi "https://doi.org/10.1111/j.1744-313x.2012.01095.x" @default.
- W1892014909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22296677" @default.
- W1892014909 hasPublicationYear "2012" @default.
- W1892014909 type Work @default.
- W1892014909 sameAs 1892014909 @default.
- W1892014909 citedByCount "20" @default.
- W1892014909 countsByYear W18920149092012 @default.
- W1892014909 countsByYear W18920149092013 @default.
- W1892014909 countsByYear W18920149092014 @default.
- W1892014909 countsByYear W18920149092015 @default.
- W1892014909 countsByYear W18920149092016 @default.
- W1892014909 countsByYear W18920149092017 @default.
- W1892014909 countsByYear W18920149092018 @default.
- W1892014909 countsByYear W18920149092022 @default.
- W1892014909 countsByYear W18920149092023 @default.
- W1892014909 crossrefType "journal-article" @default.
- W1892014909 hasAuthorship W1892014909A5022420274 @default.
- W1892014909 hasAuthorship W1892014909A5033858904 @default.
- W1892014909 hasAuthorship W1892014909A5050042609 @default.
- W1892014909 hasAuthorship W1892014909A5067381987 @default.
- W1892014909 hasAuthorship W1892014909A5079602397 @default.
- W1892014909 hasAuthorship W1892014909A5080557082 @default.
- W1892014909 hasAuthorship W1892014909A5087398782 @default.
- W1892014909 hasAuthorship W1892014909A5087865591 @default.
- W1892014909 hasBestOaLocation W18920149092 @default.
- W1892014909 hasConcept C104317684 @default.
- W1892014909 hasConcept C126322002 @default.
- W1892014909 hasConcept C142724271 @default.
- W1892014909 hasConcept C146304588 @default.
- W1892014909 hasConcept C180754005 @default.
- W1892014909 hasConcept C189413060 @default.
- W1892014909 hasConcept C203014093 @default.
- W1892014909 hasConcept C2776645655 @default.
- W1892014909 hasConcept C2778458888 @default.
- W1892014909 hasConcept C2779134260 @default.
- W1892014909 hasConcept C2780758401 @default.
- W1892014909 hasConcept C2908647359 @default.