Matches in SemOpenAlex for { <https://semopenalex.org/work/W1892016172> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1892016172 endingPage "95" @default.
- W1892016172 startingPage "189" @default.
- W1892016172 abstract "One of the proposed anticonvulsant actions of phenytoin (5,5'-diphenylhydantoin) is the suppression of calcium movement through cell membranes. However, it is not known how phenytoin interacts with calcium channels to inhibit calcium accumulation in various preparations, or to interfere with calcium-dependent neurotransmitter release. The objective of the present study was to examine whether phenytoin directly blocks voltage-dependent calcium channels of N1E-115 neuroblastoma, and if so, to determine what properties of channel gating are modified by this anticonvulsant. Calcium channel currents as carried by barium were recorded with the whole-cell voltage clamp technique. Low-threshold, transient currents (type I) were activated at membrane potentials more positive than -50 mV. Type I currents were of maximum amplitude at -20 or -10 mV. High-threshold, sustained currents (type II) were activated at potentials more positive than -10 mV. Application of phenytoin, at concentrations ranging from 3 to 100 microM, suppressed type I currents without changing their time course or voltage dependence of activation. Type II currents, on the other hand, were insensitive to phenytoin within this concentration range. The block of type I currents by phenytoin was enhanced when the membrane was maintained at more depolarized holding potentials, due to a hyperpolarizing shift in the steady-state inactivation relationship. In addition to the resting block of type I channels, phenytoin exerted an additional component of blocking at stimulation frequencies higher than 0.5 Hz. These voltage- and frequency-dependent blocking actions suggest that phenytoin shifts the channel population toward the inactivated state, allowing fewer channels to open during membrane depolarization.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W1892016172 created "2016-06-24" @default.
- W1892016172 creator A5015578759 @default.
- W1892016172 creator A5017614301 @default.
- W1892016172 creator A5068776104 @default.
- W1892016172 date "1988-07-01" @default.
- W1892016172 modified "2023-10-17" @default.
- W1892016172 title "Mechanisms of calcium channel block by phenytoin." @default.
- W1892016172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2455791" @default.
- W1892016172 hasPublicationYear "1988" @default.
- W1892016172 type Work @default.
- W1892016172 sameAs 1892016172 @default.
- W1892016172 citedByCount "39" @default.
- W1892016172 countsByYear W18920161722016 @default.
- W1892016172 countsByYear W18920161722018 @default.
- W1892016172 crossrefType "journal-article" @default.
- W1892016172 hasAuthorship W1892016172A5015578759 @default.
- W1892016172 hasAuthorship W1892016172A5017614301 @default.
- W1892016172 hasAuthorship W1892016172A5068776104 @default.
- W1892016172 hasConcept C100837961 @default.
- W1892016172 hasConcept C12554922 @default.
- W1892016172 hasConcept C169760540 @default.
- W1892016172 hasConcept C178790620 @default.
- W1892016172 hasConcept C181911157 @default.
- W1892016172 hasConcept C185263204 @default.
- W1892016172 hasConcept C185592680 @default.
- W1892016172 hasConcept C18699975 @default.
- W1892016172 hasConcept C2775858608 @default.
- W1892016172 hasConcept C2778186239 @default.
- W1892016172 hasConcept C2778337148 @default.
- W1892016172 hasConcept C2908647359 @default.
- W1892016172 hasConcept C30979828 @default.
- W1892016172 hasConcept C519063684 @default.
- W1892016172 hasConcept C55493867 @default.
- W1892016172 hasConcept C71924100 @default.
- W1892016172 hasConcept C85520022 @default.
- W1892016172 hasConcept C86803240 @default.
- W1892016172 hasConcept C99454951 @default.
- W1892016172 hasConceptScore W1892016172C100837961 @default.
- W1892016172 hasConceptScore W1892016172C12554922 @default.
- W1892016172 hasConceptScore W1892016172C169760540 @default.
- W1892016172 hasConceptScore W1892016172C178790620 @default.
- W1892016172 hasConceptScore W1892016172C181911157 @default.
- W1892016172 hasConceptScore W1892016172C185263204 @default.
- W1892016172 hasConceptScore W1892016172C185592680 @default.
- W1892016172 hasConceptScore W1892016172C18699975 @default.
- W1892016172 hasConceptScore W1892016172C2775858608 @default.
- W1892016172 hasConceptScore W1892016172C2778186239 @default.
- W1892016172 hasConceptScore W1892016172C2778337148 @default.
- W1892016172 hasConceptScore W1892016172C2908647359 @default.
- W1892016172 hasConceptScore W1892016172C30979828 @default.
- W1892016172 hasConceptScore W1892016172C519063684 @default.
- W1892016172 hasConceptScore W1892016172C55493867 @default.
- W1892016172 hasConceptScore W1892016172C71924100 @default.
- W1892016172 hasConceptScore W1892016172C85520022 @default.
- W1892016172 hasConceptScore W1892016172C86803240 @default.
- W1892016172 hasConceptScore W1892016172C99454951 @default.
- W1892016172 hasIssue "1" @default.
- W1892016172 hasLocation W18920161721 @default.
- W1892016172 hasOpenAccess W1892016172 @default.
- W1892016172 hasPrimaryLocation W18920161721 @default.
- W1892016172 hasRelatedWork W146230617 @default.
- W1892016172 hasRelatedWork W1892016172 @default.
- W1892016172 hasRelatedWork W1914306281 @default.
- W1892016172 hasRelatedWork W1963552271 @default.
- W1892016172 hasRelatedWork W1982194850 @default.
- W1892016172 hasRelatedWork W2017479962 @default.
- W1892016172 hasRelatedWork W2185967238 @default.
- W1892016172 hasRelatedWork W2402051323 @default.
- W1892016172 hasRelatedWork W2474719414 @default.
- W1892016172 hasRelatedWork W994978426 @default.
- W1892016172 hasVolume "246" @default.
- W1892016172 isParatext "false" @default.
- W1892016172 isRetracted "false" @default.
- W1892016172 magId "1892016172" @default.
- W1892016172 workType "article" @default.