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• W1892109225 abstract "Memory deficits are a common complaint of patients with posttraumatic stress disorder (PTSD). Despite vivid trauma-related memory, previous studies report memory impairment for nontrauma-related stimuli when compared to controls, specifically in associative memory (Guez et al., 2011). Healthy individuals show hemispheric memory asymmetry with left-prefrontal lateralization of encoding and right-prefrontal lateralization of episodic retrieval, suggesting a role for interhemispheric communication in memory-related tasks (Gazzaniga, 2000; Ringo, Doty, Demeter, & Simard, 1994). Because brain magnetic resonance imaging (bMRI) studies in PTSD patients report volume changes in various regions, including white matter and corpus callosum (CC), we aimed to test the relationship between memory deficits and CC volume in PTSD patients. We probed for specific alterations in associative memory in PTSD and measured the volume of subportions within the CC employing bMRI. Our main finding was a reduction in CC white-matter volume in PTSD patients, as compared to controls, t(35) = −2.7, p = .010, that was correlated with lower associative performance (r = .76, p = .003). We propose that CC volume reduction is a substrate for the associative memory deficits found in PTSD. Traditional and Simplified Chinese Abstracts by AsianSTSS 標題：創傷後壓力症胼胝體縮小顯示腦半球連接對聯想記憶的重要性 撮要：創傷後壓力症(PTSD) 病人經常投訴記憶減退。昔日研究指出儘管有着鮮明的創傷記憶，但與對照比較，病人對非創傷刺激的記憶(特別是聯想記憶) 存在障礙(Guez et al.,2011)。健康人士腦半球記憶不對稱，左前額葉側重記憶編碼而右前額葉偏重情節記憶提取，因而腦半球互相連接在記憶事項有相當角色(Gazzaniga, 2000；Ringo, Doty, Demeter & Simard, 1994)。PTSD病人的腦磁共振造影 (bMRI) 研究顯示腦區 (包括白質和胼胝體(CC) ) 有變化 。我們試圖在PTSD病人中找尋記憶障礙和CC體積的關係，利用bMRI量度CC中子分區的體積，和測試PTSD中聯想記憶的獨特變化。主要發現為：對比對照組，PTSD病人有CC白質體積縮小，t(35)= - 2.7, p= .010, 而與較差聯想表現有關連(r= .76, p= .003)。我們提出在PTSD中CC體積減少是聯想記憶障礙的腦部基板。 标题：创伤后压力症胼胝体缩小显示脑半球连接对联想记忆的重要性 撮要：创伤后压力症(PTSD) 病人经常投诉记忆减退。昔日研究指出尽管有鲜明的创伤记忆，但与对照比较，病人对非创伤刺激的记忆(特别是联想记忆) 存在障碍(Guez et al.,2011)。健康人士脑半球记忆不对称，左前额叶侧重记忆编码而右前额叶偏重情节记忆提取，所以脑半球互相连接在记忆事项有相当角色(Gazzaniga, 2000；Ringo, Doty, Demeter & Simard, 1994)。PTSD病人的脑磁共振造影 (bMRI) 研究显示脑区 (包括白质和胼胝体(CC) ) 有变化 。我们试图在PTSD病人中找寻记忆障碍和CC体积的关系，利用bMRI量度CC中子分区的体积，和测试PTSD中联想记忆的独特变化。主要发现为：对比对照组，PTSD病人有CC白质体积缩小，t(35)= - 2.7, p= .010, 而与较差联想表现有关连(r= .76, p= .003)。我们提出在PTSD中CC体积减少是联想记忆障碍的脑部基板。" @default.
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• W1892109225 date "2014-01-28" @default.
• W1892109225 modified "2023-09-26" @default.
• W1892109225 title "Reduced Corpus-Callosum Volume in Posttraumatic Stress Disorder Highlights the Importance of Interhemispheric Connectivity for Associative Memory" @default.
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• W1892109225 doi "https://doi.org/10.1002/jts.21887" @default.
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