Matches in SemOpenAlex for { <https://semopenalex.org/work/W1892185840> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1892185840 abstract "The inflammatory phenotype of acute asthma exacerbations has been reported to be characterized by a heterogeneous infiltrate with eosinophils and large numbers of neutrophils in sputum as well as broncho-alveolar lavage (BAL). Epidemiological surveys suggested viral infection of the respiratory tract as the main trigger. Double stranded RNA is produced as an intermediate during replication of respiratory viruses and can be sensed by toll-like receptor 3 (TLR3). TLR3 could therefore play a key role in the pathogenesis of acute asthma exacerbation. Our study aimed at i) establishing a mouse model of TLR3 trigged asthma exacerbation and ii) clarifying the underlying mechanisms. Intra-nasal (i.n.) application of the TLR3 ligand poly (I:C) induced an exacerbation of experimental allergic asthma in mice characterized by enhanced release of pro-inflammatory cytokines, mucus production, and pronounced airway hyperresponsiveness (AHR). Exacerbation included marked infiltration of neutrophils and T helper 17 (TH17) cells. . None of these characteristics could be observed in mice lacking IL-17A, indicating an essential role of this cytokine in mediating TLR3 triggered asthma exacerbation. Furthermore, in IL-23p19 mice, which lack IL-17 producing γδ T cells and TH17 cells, local application of poly (I:C) again provoked asthma exacerbation. Therefore, we suggest IL-17 producing NKT cells as main cell type involved in TLR3 triggered exacerbation of allergic asthma in mice." @default.
- W1892185840 created "2016-06-24" @default.
- W1892185840 creator A5021401129 @default.
- W1892185840 creator A5043459278 @default.
- W1892185840 creator A5072405396 @default.
- W1892185840 creator A5080381047 @default.
- W1892185840 creator A5083339565 @default.
- W1892185840 creator A5084901270 @default.
- W1892185840 date "2013-09-01" @default.
- W1892185840 modified "2023-09-26" @default.
- W1892185840 title "LSC 2013 abstract - TLR-3 triggered aggravation of experimental asthma depends on IL-17" @default.
- W1892185840 hasPublicationYear "2013" @default.
- W1892185840 type Work @default.
- W1892185840 sameAs 1892185840 @default.
- W1892185840 citedByCount "0" @default.
- W1892185840 crossrefType "journal-article" @default.
- W1892185840 hasAuthorship W1892185840A5021401129 @default.
- W1892185840 hasAuthorship W1892185840A5043459278 @default.
- W1892185840 hasAuthorship W1892185840A5072405396 @default.
- W1892185840 hasAuthorship W1892185840A5080381047 @default.
- W1892185840 hasAuthorship W1892185840A5083339565 @default.
- W1892185840 hasAuthorship W1892185840A5084901270 @default.
- W1892185840 hasConcept C136449434 @default.
- W1892185840 hasConcept C203014093 @default.
- W1892185840 hasConcept C207480886 @default.
- W1892185840 hasConcept C2776042228 @default.
- W1892185840 hasConcept C2776709828 @default.
- W1892185840 hasConcept C2777014857 @default.
- W1892185840 hasConcept C2778420691 @default.
- W1892185840 hasConcept C2778690821 @default.
- W1892185840 hasConcept C2780942790 @default.
- W1892185840 hasConcept C2909082789 @default.
- W1892185840 hasConcept C71924100 @default.
- W1892185840 hasConcept C8891405 @default.
- W1892185840 hasConceptScore W1892185840C136449434 @default.
- W1892185840 hasConceptScore W1892185840C203014093 @default.
- W1892185840 hasConceptScore W1892185840C207480886 @default.
- W1892185840 hasConceptScore W1892185840C2776042228 @default.
- W1892185840 hasConceptScore W1892185840C2776709828 @default.
- W1892185840 hasConceptScore W1892185840C2777014857 @default.
- W1892185840 hasConceptScore W1892185840C2778420691 @default.
- W1892185840 hasConceptScore W1892185840C2778690821 @default.
- W1892185840 hasConceptScore W1892185840C2780942790 @default.
- W1892185840 hasConceptScore W1892185840C2909082789 @default.
- W1892185840 hasConceptScore W1892185840C71924100 @default.
- W1892185840 hasConceptScore W1892185840C8891405 @default.
- W1892185840 hasLocation W18921858401 @default.
- W1892185840 hasOpenAccess W1892185840 @default.
- W1892185840 hasPrimaryLocation W18921858401 @default.
- W1892185840 hasRelatedWork W1881320175 @default.
- W1892185840 hasRelatedWork W1998836153 @default.
- W1892185840 hasRelatedWork W2040701593 @default.
- W1892185840 hasRelatedWork W2087143527 @default.
- W1892185840 hasRelatedWork W2108802034 @default.
- W1892185840 hasRelatedWork W2163635921 @default.
- W1892185840 hasRelatedWork W2256158091 @default.
- W1892185840 hasRelatedWork W2345227496 @default.
- W1892185840 hasRelatedWork W2551679357 @default.
- W1892185840 hasRelatedWork W2556111778 @default.
- W1892185840 hasRelatedWork W2768249729 @default.
- W1892185840 hasRelatedWork W2774472372 @default.
- W1892185840 hasRelatedWork W2891956534 @default.
- W1892185840 hasRelatedWork W2901429309 @default.
- W1892185840 hasRelatedWork W2978483213 @default.
- W1892185840 hasRelatedWork W2985886707 @default.
- W1892185840 hasRelatedWork W2990419595 @default.
- W1892185840 hasRelatedWork W3041769706 @default.
- W1892185840 hasRelatedWork W3093942108 @default.
- W1892185840 hasRelatedWork W1941778088 @default.
- W1892185840 hasVolume "42" @default.
- W1892185840 isParatext "false" @default.
- W1892185840 isRetracted "false" @default.
- W1892185840 magId "1892185840" @default.
- W1892185840 workType "article" @default.