Matches in SemOpenAlex for { <https://semopenalex.org/work/W1892230621> ?p ?o ?g. }
- W1892230621 endingPage "5189" @default.
- W1892230621 startingPage "5181" @default.
- W1892230621 abstract "Intravenous Igs (IVIg) therapy is widely used as an immunomodulatory strategy in inflammatory pathologies and is suggested to promote cancer regression. Because progression of tumors depends on their ability to redirect the polarization state of tumor-associated macrophages (from M1/immunogenic/proinflammatory to M2/anti-inflammatory), we have evaluated whether IVIg limits tumor progression and dissemination through modulation of macrophage polarization. In vitro, IVIg inhibited proinflammatory cytokine production from M1 macrophages and induced a M2-to-M1 polarization switch on human and murine M2 macrophages. In vivo, IVIg modified the polarization of tumor-associated myeloid cells in a Fcεr1γ chain-dependent manner, modulated cytokine blood levels in tumor-bearing animals, and impaired tumor progression via FcγRIII (CD16), FcγRIV, and FcRγ engagement, the latter two effects being macrophage mediated. Therefore, IVIg immunomodulatory activity is dependent on the polarization state of the responding macrophages, and its ability to trigger a M2-to-M1 macrophage polarization switch might be therapeutically useful in cancer, in which proinflammatory or immunogenic functions should be promoted." @default.
- W1892230621 created "2016-06-24" @default.
- W1892230621 creator A5002624533 @default.
- W1892230621 creator A5009068683 @default.
- W1892230621 creator A5012820382 @default.
- W1892230621 creator A5020184761 @default.
- W1892230621 creator A5029545795 @default.
- W1892230621 creator A5035527592 @default.
- W1892230621 creator A5047641235 @default.
- W1892230621 creator A5052406854 @default.
- W1892230621 creator A5055174431 @default.
- W1892230621 creator A5055527712 @default.
- W1892230621 creator A5064978271 @default.
- W1892230621 creator A5071064598 @default.
- W1892230621 creator A5073808135 @default.
- W1892230621 creator A5079003683 @default.
- W1892230621 creator A5082860862 @default.
- W1892230621 creator A5083181264 @default.
- W1892230621 creator A5085267148 @default.
- W1892230621 date "2014-11-15" @default.
- W1892230621 modified "2023-10-18" @default.
- W1892230621 title "Intravenous Immunoglobulin Promotes Antitumor Responses by Modulating Macrophage Polarization" @default.
- W1892230621 cites W1491316832 @default.
- W1892230621 cites W1493742659 @default.
- W1892230621 cites W1942388905 @default.
- W1892230621 cites W1969892170 @default.
- W1892230621 cites W1979982103 @default.
- W1892230621 cites W1982871919 @default.
- W1892230621 cites W1984803858 @default.
- W1892230621 cites W1986736465 @default.
- W1892230621 cites W1991240417 @default.
- W1892230621 cites W1996213381 @default.
- W1892230621 cites W1998984179 @default.
- W1892230621 cites W2001717792 @default.
- W1892230621 cites W2021757899 @default.
- W1892230621 cites W2036506588 @default.
- W1892230621 cites W2038459489 @default.
- W1892230621 cites W2041944580 @default.
- W1892230621 cites W2051118090 @default.
- W1892230621 cites W2054472394 @default.
- W1892230621 cites W2060672294 @default.
- W1892230621 cites W2061123122 @default.
- W1892230621 cites W2063680739 @default.
- W1892230621 cites W2065210647 @default.
- W1892230621 cites W2070255464 @default.
- W1892230621 cites W2084423382 @default.
- W1892230621 cites W2084516448 @default.
- W1892230621 cites W2088002019 @default.
- W1892230621 cites W2088847779 @default.
- W1892230621 cites W2091712626 @default.
- W1892230621 cites W2094655231 @default.
- W1892230621 cites W2101287360 @default.
- W1892230621 cites W2101328621 @default.
- W1892230621 cites W2114050989 @default.
- W1892230621 cites W2114496790 @default.
- W1892230621 cites W2118200665 @default.
- W1892230621 cites W2129311237 @default.
- W1892230621 cites W2136732030 @default.
- W1892230621 cites W2143766145 @default.
- W1892230621 cites W2149142217 @default.
- W1892230621 cites W2150026822 @default.
- W1892230621 cites W2151105551 @default.
- W1892230621 cites W2151935175 @default.
- W1892230621 cites W2152091665 @default.
- W1892230621 cites W2159287844 @default.
- W1892230621 cites W2162444234 @default.
- W1892230621 cites W2167485774 @default.
- W1892230621 cites W2169211336 @default.
- W1892230621 cites W4250007760 @default.
- W1892230621 doi "https://doi.org/10.4049/jimmunol.1303375" @default.
- W1892230621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25326025" @default.
- W1892230621 hasPublicationYear "2014" @default.
- W1892230621 type Work @default.
- W1892230621 sameAs 1892230621 @default.
- W1892230621 citedByCount "38" @default.
- W1892230621 countsByYear W18922306212015 @default.
- W1892230621 countsByYear W18922306212016 @default.
- W1892230621 countsByYear W18922306212017 @default.
- W1892230621 countsByYear W18922306212018 @default.
- W1892230621 countsByYear W18922306212019 @default.
- W1892230621 countsByYear W18922306212020 @default.
- W1892230621 countsByYear W18922306212021 @default.
- W1892230621 countsByYear W18922306212022 @default.
- W1892230621 countsByYear W18922306212023 @default.
- W1892230621 crossrefType "journal-article" @default.
- W1892230621 hasAuthorship W1892230621A5002624533 @default.
- W1892230621 hasAuthorship W1892230621A5009068683 @default.
- W1892230621 hasAuthorship W1892230621A5012820382 @default.
- W1892230621 hasAuthorship W1892230621A5020184761 @default.
- W1892230621 hasAuthorship W1892230621A5029545795 @default.
- W1892230621 hasAuthorship W1892230621A5035527592 @default.
- W1892230621 hasAuthorship W1892230621A5047641235 @default.
- W1892230621 hasAuthorship W1892230621A5052406854 @default.
- W1892230621 hasAuthorship W1892230621A5055174431 @default.
- W1892230621 hasAuthorship W1892230621A5055527712 @default.
- W1892230621 hasAuthorship W1892230621A5064978271 @default.
- W1892230621 hasAuthorship W1892230621A5071064598 @default.
- W1892230621 hasAuthorship W1892230621A5073808135 @default.