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• W1892337648 endingPage "832" @default.
• W1892337648 startingPage "821" @default.
• W1892337648 abstract "Abstract We have used three cloned DNA sequences consisting of (1) part of the suppressor of forked transcription unit, (2) a cloned 359-bp satellite, and (3), a type I ribosomal insertion, to examine the structure of the base of the X chromosome of Drosophila melanogaster where different chromatin types are found in juxtaposition. A DNA probe from the suppressor of forked locus hybridizes exclusively to the very proximal polytenized part of division 20, which forms part of the beta-heterochromatin of the chromocenter. The cloned 359-bp satellite sequence, which derives from the proximal mitotic heterochromatin between the centromere and the ribosomal genes, hybridizes to the under replicated alpha-heterochromatin of the chromocenter. The type I insertion sequence, which has major locations in the ribosomal genes and in the distal mitotic heterochromatin of the X chromosome, hybridizes as expected to the nucleolus but does not hybridize to the beta-heterochromatic division 20 of the polytene X chromosome. Our molecular data reveal that the suppressor of forked locus, which on cytogenetic grounds is the most proximal ordinary gene on the X chromosome, is very close to the junction of the polytenized and non-polytenized region of the X chromosome. The data have implications for the structure of beta-heterochromatin-alpha-heterochromatin junction zones in both mitotic and polytene chromosomes, and are discussed with reference to models of chromosome structure." @default.
• W1892337648 created "2016-06-24" @default.
• W1892337648 creator A5006267847 @default.
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• W1892337648 date "1990-08-01" @default.
• W1892337648 modified "2023-10-12" @default.
• W1892337648 title "Molecular and cytogenetic analysis of the heterochromatin-euchromatin junction region of the Drosophila melanogaster X chromosome using cloned DNA sequences." @default.
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• W1892337648 doi "https://doi.org/10.1093/genetics/125.4.821" @default.
• W1892337648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1204108" @default.
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