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- W1892783136 abstract "Despite aggressive treatments including surgical resection, radiation therapy, and cytotoxic chemotherapy, brain cancer remains incurable with a median survival under 15 months and a 2-year survival of 26.5 per cent1,2. The failure of conventional oncology to eradicate glioblastoma, the most common malignant primary brain tumour, has prompted investigators to look for new and more targeted therapeutic options as well as for improved prognostic biomarkers3. It is recognized that brain cancer emerges from multiple alterations that induce changes in expression patterns of genes and proteins that function in complex networks controlling critical cellular functions4. A primary task of the tumour research is the translation of molecular biomarkers into clinical practice. However, there is still not agreement with regard to the sequence and nature of steps that need to be taken to warrant efficient translation of prognostic and/or predictive biomarkers into clinical use and to the introduction of novel therapeutic strategies5." @default.
- W1892783136 created "2016-06-24" @default.
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- W1892783136 date "2013-05-01" @default.
- W1892783136 modified "2023-09-24" @default.
- W1892783136 title "Rethinking immunotherapy for brain cancers in the light of cancer complexity." @default.
- W1892783136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3734675" @default.
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