Matches in SemOpenAlex for { <https://semopenalex.org/work/W1892912449> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1892912449 endingPage "51" @default.
- W1892912449 startingPage "45" @default.
- W1892912449 abstract "Freise, K. J., Newbound, G. C., Tudan, C., Clark, T. P. Naloxone reversal of an overdose of a novel, long‐acting transdermal fentanyl solution in laboratory Beagles. J. vet. Pharmacol. Therap . 35 (Suppl. 2), 45–51. Opioid overdose in dogs is manifested by clinical signs such as excessive sedation, bradycardia, and hypothermia. The ability of two different intramuscular (i.m.) naloxone reversal regimens to reverse the opioid‐induced effects of a fivefold overdose of long‐acting transdermal fentanyl solution was evaluated in dogs. Twenty‐four healthy Beagles were administered a single 13 mg/kg dose (fivefold overdose) of transdermal fentanyl solution and randomized to two naloxone reversal regimen treatment groups, hourly administration for 8 h of 40 ( n = 8) or 160 μg/kg i.m. ( n = 16). All dogs were sedated and had reduced body temperatures and heart rates (HRs) prior to naloxone administration. Both dosage regimens significantly reduced sedation ( P < 0.001), and the 160 μg/kg naloxone regimen resulted in a nearly threefold lower odds of sedation than that of the 40 μg/kg i.m. naloxone regimen ( P < 0.05). Additionally, naloxone significantly increased the mean body temperatures and HR ( P < 0.001), although the 160 μg/kg regimen increased body temperature and HR more ( P < 0.05). However, the narcotic side effects of fentanyl returned within 1–3 h following termination of the naloxone dosage regimens. The opioid‐induced effects of an overdose of transdermal fentanyl solution can be safely and effectively reversed by either 40 or 160 μg/kg i.m. naloxone administered at hourly intervals." @default.
- W1892912449 created "2016-06-24" @default.
- W1892912449 creator A5018066673 @default.
- W1892912449 creator A5021220272 @default.
- W1892912449 creator A5058733601 @default.
- W1892912449 creator A5088046480 @default.
- W1892912449 date "2012-06-25" @default.
- W1892912449 modified "2023-09-25" @default.
- W1892912449 title "Naloxone reversal of an overdose of a novel, long-acting transdermal fentanyl solution in laboratory Beagles" @default.
- W1892912449 cites W1510237081 @default.
- W1892912449 cites W1522902420 @default.
- W1892912449 cites W1578357875 @default.
- W1892912449 cites W1968166370 @default.
- W1892912449 cites W2008628436 @default.
- W1892912449 cites W2013215300 @default.
- W1892912449 cites W2039642650 @default.
- W1892912449 cites W2042270576 @default.
- W1892912449 cites W2076184556 @default.
- W1892912449 cites W2082124495 @default.
- W1892912449 cites W2110680952 @default.
- W1892912449 cites W2142635246 @default.
- W1892912449 cites W2147823893 @default.
- W1892912449 cites W2165269437 @default.
- W1892912449 cites W2174863371 @default.
- W1892912449 cites W4234587695 @default.
- W1892912449 doi "https://doi.org/10.1111/j.1365-2885.2012.01409.x" @default.
- W1892912449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22731775" @default.
- W1892912449 hasPublicationYear "2012" @default.
- W1892912449 type Work @default.
- W1892912449 sameAs 1892912449 @default.
- W1892912449 citedByCount "23" @default.
- W1892912449 countsByYear W18929124492012 @default.
- W1892912449 countsByYear W18929124492013 @default.
- W1892912449 countsByYear W18929124492014 @default.
- W1892912449 countsByYear W18929124492015 @default.
- W1892912449 countsByYear W18929124492016 @default.
- W1892912449 countsByYear W18929124492017 @default.
- W1892912449 countsByYear W18929124492018 @default.
- W1892912449 countsByYear W18929124492019 @default.
- W1892912449 countsByYear W18929124492021 @default.
- W1892912449 countsByYear W18929124492022 @default.
- W1892912449 crossrefType "journal-article" @default.
- W1892912449 hasAuthorship W1892912449A5018066673 @default.
- W1892912449 hasAuthorship W1892912449A5021220272 @default.
- W1892912449 hasAuthorship W1892912449A5058733601 @default.
- W1892912449 hasAuthorship W1892912449A5088046480 @default.
- W1892912449 hasBestOaLocation W18929124491 @default.
- W1892912449 hasConcept C126322002 @default.
- W1892912449 hasConcept C141071460 @default.
- W1892912449 hasConcept C170493617 @default.
- W1892912449 hasConcept C205679159 @default.
- W1892912449 hasConcept C2776814716 @default.
- W1892912449 hasConcept C2777389121 @default.
- W1892912449 hasConcept C2778750930 @default.
- W1892912449 hasConcept C2779148768 @default.
- W1892912449 hasConcept C2781063702 @default.
- W1892912449 hasConcept C2781072394 @default.
- W1892912449 hasConcept C2781413609 @default.
- W1892912449 hasConcept C42219234 @default.
- W1892912449 hasConcept C71924100 @default.
- W1892912449 hasConcept C98274493 @default.
- W1892912449 hasConceptScore W1892912449C126322002 @default.
- W1892912449 hasConceptScore W1892912449C141071460 @default.
- W1892912449 hasConceptScore W1892912449C170493617 @default.
- W1892912449 hasConceptScore W1892912449C205679159 @default.
- W1892912449 hasConceptScore W1892912449C2776814716 @default.
- W1892912449 hasConceptScore W1892912449C2777389121 @default.
- W1892912449 hasConceptScore W1892912449C2778750930 @default.
- W1892912449 hasConceptScore W1892912449C2779148768 @default.
- W1892912449 hasConceptScore W1892912449C2781063702 @default.
- W1892912449 hasConceptScore W1892912449C2781072394 @default.
- W1892912449 hasConceptScore W1892912449C2781413609 @default.
- W1892912449 hasConceptScore W1892912449C42219234 @default.
- W1892912449 hasConceptScore W1892912449C71924100 @default.
- W1892912449 hasConceptScore W1892912449C98274493 @default.
- W1892912449 hasIssue "s2" @default.
- W1892912449 hasLocation W18929124491 @default.
- W1892912449 hasLocation W18929124492 @default.
- W1892912449 hasOpenAccess W1892912449 @default.
- W1892912449 hasPrimaryLocation W18929124491 @default.
- W1892912449 hasRelatedWork W1892912449 @default.
- W1892912449 hasRelatedWork W2017945832 @default.
- W1892912449 hasRelatedWork W2067032885 @default.
- W1892912449 hasRelatedWork W2759575206 @default.
- W1892912449 hasRelatedWork W2887406189 @default.
- W1892912449 hasRelatedWork W2896333848 @default.
- W1892912449 hasRelatedWork W2921971750 @default.
- W1892912449 hasRelatedWork W3034888056 @default.
- W1892912449 hasRelatedWork W3171387315 @default.
- W1892912449 hasRelatedWork W3204485469 @default.
- W1892912449 hasVolume "35" @default.
- W1892912449 isParatext "false" @default.
- W1892912449 isRetracted "false" @default.
- W1892912449 magId "1892912449" @default.
- W1892912449 workType "article" @default.