FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1892992006> ?p ?o ?g. }

• W1892992006 endingPage "7" @default.
• W1892992006 startingPage "1" @default.
• W1892992006 abstract "Stem cells are a powerful resource for cell-based transplantation therapies, but understanding of stem cell differentiation at the molecular level is not clear yet. We hypothesized that the Wnt pathway controls stem cell maintenance and neural differentiation. We have characterized the transcriptional expression of Wnt during the neural differentiation of hADSCs. After neural induction, the expressions of Wnt2, Wnt4, and Wnt11 were decreased, but the expression of Wnt5a was increased compared with primary hADSCs in RT-PCR analysis. In addition, the expression levels of most Fzds and LRP5/6 ligand were decreased, but not Fzd3 and Fzd5. Furthermore, Dvl1 and RYK expression levels were downregulated in NI-hADSCs. There were no changes in the expression of ß-catenin and GSK3ß. Interestingly, Wnt5a expression was highly increased in NI-hADSCs by real time RT-PCR analysis and western blot. Wnt5a level was upregulated after neural differentiation and Wnt3, Dvl2, and Naked1 levels were downregulated. Finally, we found that the JNK expression was increased after neural induction and ERK level was decreased. Thus, this study shows for the first time how a single Wnt5a ligand can activate the neural differentiation pathway through the activation of Wnt5a/JNK pathway by binding Fzd3 and Fzd5 and directing Axin/GSK-3ß in hADSCs." @default.
• W1892992006 created "2016-06-24" @default.
• W1892992006 creator A5035114925 @default.
• W1892992006 creator A5048001031 @default.
• W1892992006 creator A5057517410 @default.
• W1892992006 date "2015-01-01" @default.
• W1892992006 modified "2023-10-17" @default.
• W1892992006 title "Neural Differentiation of Human Adipose Tissue-Derived Stem Cells Involves Activation of the Wnt5a/JNK Signalling" @default.
• W1892992006 cites W1563128033 @default.
• W1892992006 cites W1965516033 @default.
• W1892992006 cites W1975703347 @default.
• W1892992006 cites W1978914404 @default.
• W1892992006 cites W1981670574 @default.
• W1892992006 cites W1982579673 @default.
• W1892992006 cites W1991737182 @default.
• W1892992006 cites W2003615946 @default.
• W1892992006 cites W2012549032 @default.
• W1892992006 cites W2019196925 @default.
• W1892992006 cites W2023525243 @default.
• W1892992006 cites W2028174844 @default.
• W1892992006 cites W2029584195 @default.
• W1892992006 cites W2029880733 @default.
• W1892992006 cites W2061468522 @default.
• W1892992006 cites W2061989491 @default.
• W1892992006 cites W2073777241 @default.
• W1892992006 cites W2079677088 @default.
• W1892992006 cites W2087124418 @default.
• W1892992006 cites W2095118457 @default.
• W1892992006 cites W2106117542 @default.
• W1892992006 cites W2122491860 @default.
• W1892992006 cites W2125916283 @default.
• W1892992006 cites W2125948664 @default.
• W1892992006 cites W2132289628 @default.
• W1892992006 cites W2136499741 @default.
• W1892992006 cites W2139211316 @default.
• W1892992006 cites W2146455000 @default.
• W1892992006 cites W2155945484 @default.
• W1892992006 cites W2158048826 @default.
• W1892992006 cites W2161428975 @default.
• W1892992006 doi "https://doi.org/10.1155/2015/178618" @default.
• W1892992006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4461786" @default.
• W1892992006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26106419" @default.
• W1892992006 hasPublicationYear "2015" @default.
• W1892992006 type Work @default.
• W1892992006 sameAs 1892992006 @default.
• W1892992006 citedByCount "37" @default.
• W1892992006 countsByYear W18929920062015 @default.
• W1892992006 countsByYear W18929920062016 @default.
• W1892992006 countsByYear W18929920062017 @default.
• W1892992006 countsByYear W18929920062018 @default.
• W1892992006 countsByYear W18929920062019 @default.
• W1892992006 countsByYear W18929920062020 @default.
• W1892992006 countsByYear W18929920062021 @default.
• W1892992006 countsByYear W18929920062022 @default.
• W1892992006 countsByYear W18929920062023 @default.
• W1892992006 crossrefType "journal-article" @default.
• W1892992006 hasAuthorship W1892992006A5035114925 @default.
• W1892992006 hasAuthorship W1892992006A5048001031 @default.
• W1892992006 hasAuthorship W1892992006A5057517410 @default.
• W1892992006 hasBestOaLocation W18929920061 @default.
• W1892992006 hasConcept C104317684 @default.
• W1892992006 hasConcept C127561419 @default.
• W1892992006 hasConcept C134018914 @default.
• W1892992006 hasConcept C136834591 @default.
• W1892992006 hasConcept C137620995 @default.
• W1892992006 hasConcept C148738053 @default.
• W1892992006 hasConcept C171089720 @default.
• W1892992006 hasConcept C185592680 @default.
• W1892992006 hasConcept C2780176071 @default.
• W1892992006 hasConcept C28328180 @default.
• W1892992006 hasConcept C502942594 @default.
• W1892992006 hasConcept C55493867 @default.
• W1892992006 hasConcept C57074206 @default.
• W1892992006 hasConcept C62478195 @default.
• W1892992006 hasConcept C86803240 @default.
• W1892992006 hasConcept C95444343 @default.
• W1892992006 hasConceptScore W1892992006C104317684 @default.
• W1892992006 hasConceptScore W1892992006C127561419 @default.
• W1892992006 hasConceptScore W1892992006C134018914 @default.
• W1892992006 hasConceptScore W1892992006C136834591 @default.
• W1892992006 hasConceptScore W1892992006C137620995 @default.
• W1892992006 hasConceptScore W1892992006C148738053 @default.
• W1892992006 hasConceptScore W1892992006C171089720 @default.
• W1892992006 hasConceptScore W1892992006C185592680 @default.
• W1892992006 hasConceptScore W1892992006C2780176071 @default.
• W1892992006 hasConceptScore W1892992006C28328180 @default.
• W1892992006 hasConceptScore W1892992006C502942594 @default.
• W1892992006 hasConceptScore W1892992006C55493867 @default.
• W1892992006 hasConceptScore W1892992006C57074206 @default.
• W1892992006 hasConceptScore W1892992006C62478195 @default.
• W1892992006 hasConceptScore W1892992006C86803240 @default.
• W1892992006 hasConceptScore W1892992006C95444343 @default.
• W1892992006 hasFunder F4320322120 @default.
• W1892992006 hasLocation W18929920061 @default.
• W1892992006 hasLocation W18929920062 @default.
• W1892992006 hasLocation W18929920063 @default.
• W1892992006 hasLocation W18929920064 @default.
• W1892992006 hasLocation W18929920065 @default.

• next