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- W1893084795 abstract "Cross‐presentation is the pathway by which exogenous antigens are routed for presentation by MHC class I molecules leading to activation of antiviral CD 8 + T ‐cell responses. However, there is little information describing the modulation of cross‐presentation and the impact of pathogen‐derived signals associated with J apanese encephalitis virus ( JEV ), which is one of the most common causes of encephalitis in humans. In this study, we demonstrate that JEV infection could suppress in vivo cross‐presentation of soluble and cell‐associated antigens, thereby generating weak CD 8 + T ‐cell responses to exogenous antigens, as evaluated by CFSE dilution of adoptively transferred CD 8 + T cells and in vivo CTL killing activity. Furthermore, CD 8α + CD 11c + dendritic cells ( DC s), which are known to be far more efficient at cross‐presenting soluble antigens, played a specific role in contributing to JEV ‐mediated inhibition of the cross‐presentation of exogenous antigens through interference with effective antigen uptake. Finally, this study provides evidence that TLR 2‐ M y D 88 and p38 MAPK signal pathway might be involved in JEV ‐mediated inhibition of cross‐presentation of soluble and cell‐associated antigens. These observations suggest that the modulation of cross‐presentation of exogenous antigens through TLR signaling has important implications for antiviral immune responses against JEV infection and the development of effective vaccination strategies." @default.
- W1893084795 created "2016-06-24" @default.
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- W1893084795 date "2012-09-10" @default.
- W1893084795 modified "2023-09-27" @default.
- W1893084795 title "Impaired cross-presentation of CD8α<sup>+</sup>CD11c<sup>+</sup>dendritic cells by Japanese encephalitis virus in a TLR2/MyD88 signal pathway-dependent manner" @default.
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- W1893084795 doi "https://doi.org/10.1002/eji.201142052" @default.
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