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- W1893345303 abstract "Cancer and chronic fatigue syndrome (CFS) are both characterised by fatigue and severe disability. Besides fatigue, certain aspects of immune dysfunctions appear to be present in both illnesses. In this regard, a literature review of overlapping immune dysfunctions in CFS and cancer is provided. Special emphasis is given to the relationship between immune dysfunctions and fatigue. Abnormalities in ribonuclease (RNase) L and hyperactivation of nuclear factor kappa beta (NF-kappaB) are present in CFS and in prostate cancer. Malfunctioning of natural killer (NK) cells has long been recognised as an important factor in the development and reoccurrence of cancer, and has been documented repeatedly in CFS patients. The dysregulation of the RNase L pathway, hyperactive NF-kappaB leading to disturbed apoptotic mechanisms and oxidative stress or excessive nitric oxide, and low NK activity may play a role in the two diseases and in the physiopathology of the common symptom fatigue. However, in cancer the relation between the immune dysfunctions and fatigue has been poorly studied. Immunological abnormalities to such as a dysregulated RNase L pathway, hyperactive NF-kappaB, increased oxidative stress and reduced NK cytotoxicity, among others, are present in both diseases. These anomalies may be part of the physiopathology of some of the common complaints, such as fatigue. Further studies to confirm the hypotheses given here are warranted." @default.
- W1893345303 created "2016-06-24" @default.
- W1893345303 creator A5019708076 @default.
- W1893345303 creator A5048009397 @default.
- W1893345303 creator A5063743576 @default.
- W1893345303 creator A5086114226 @default.
- W1893345303 date "2009-11-01" @default.
- W1893345303 modified "2023-10-16" @default.
- W1893345303 title "Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue?" @default.
- W1893345303 cites W113716995 @default.
- W1893345303 cites W11486939 @default.
- W1893345303 cites W130455168 @default.
- W1893345303 cites W1494692328 @default.
- W1893345303 cites W1550909327 @default.
- W1893345303 cites W1866438480 @default.
- W1893345303 cites W187494191 @default.
- W1893345303 cites W1964605210 @default.
- W1893345303 cites W1966134557 @default.
- W1893345303 cites W1966733272 @default.
- W1893345303 cites W1969846494 @default.
- W1893345303 cites W1971324193 @default.
- W1893345303 cites W1976772617 @default.
- W1893345303 cites W1978689372 @default.
- W1893345303 cites W1982662129 @default.
- W1893345303 cites W1982774827 @default.
- W1893345303 cites W1985501733 @default.
- W1893345303 cites W1994362859 @default.
- W1893345303 cites W1995071981 @default.
- W1893345303 cites W1997021750 @default.
- W1893345303 cites W2002969389 @default.
- W1893345303 cites W2003982318 @default.
- W1893345303 cites W2009595759 @default.
- W1893345303 cites W2011240027 @default.
- W1893345303 cites W2011270511 @default.
- W1893345303 cites W2014833819 @default.
- W1893345303 cites W2017973963 @default.
- W1893345303 cites W2022244154 @default.
- W1893345303 cites W2027471608 @default.
- W1893345303 cites W2028051513 @default.
- W1893345303 cites W2028240889 @default.
- W1893345303 cites W2029442522 @default.
- W1893345303 cites W2029676928 @default.
- W1893345303 cites W2029782698 @default.
- W1893345303 cites W2032884648 @default.
- W1893345303 cites W2034361293 @default.
- W1893345303 cites W2036071389 @default.
- W1893345303 cites W2039271100 @default.
- W1893345303 cites W2039817035 @default.
- W1893345303 cites W2042047630 @default.
- W1893345303 cites W2044855136 @default.
- W1893345303 cites W2045830093 @default.
- W1893345303 cites W2046013214 @default.
- W1893345303 cites W2046056065 @default.
- W1893345303 cites W2047205134 @default.
- W1893345303 cites W2049350925 @default.
- W1893345303 cites W2050166914 @default.
- W1893345303 cites W2053994623 @default.
- W1893345303 cites W2054243400 @default.
- W1893345303 cites W2055354965 @default.
- W1893345303 cites W2056501152 @default.
- W1893345303 cites W2058308967 @default.
- W1893345303 cites W2059132322 @default.
- W1893345303 cites W2067371565 @default.
- W1893345303 cites W2074349361 @default.
- W1893345303 cites W2084501255 @default.
- W1893345303 cites W2085791773 @default.
- W1893345303 cites W2087103155 @default.
- W1893345303 cites W2092663976 @default.
- W1893345303 cites W2094598862 @default.
- W1893345303 cites W2096324963 @default.
- W1893345303 cites W2097015662 @default.
- W1893345303 cites W2098000889 @default.
- W1893345303 cites W2098287790 @default.
- W1893345303 cites W2099697117 @default.
- W1893345303 cites W2100022997 @default.
- W1893345303 cites W2100884687 @default.
- W1893345303 cites W2101783501 @default.
- W1893345303 cites W2104109715 @default.
- W1893345303 cites W2105534209 @default.
- W1893345303 cites W2106848257 @default.
- W1893345303 cites W2109059363 @default.
- W1893345303 cites W2109286577 @default.
- W1893345303 cites W2110739933 @default.
- W1893345303 cites W2111340940 @default.
- W1893345303 cites W2112547385 @default.
- W1893345303 cites W2114426595 @default.
- W1893345303 cites W2118385502 @default.
- W1893345303 cites W2118809707 @default.
- W1893345303 cites W2122467970 @default.
- W1893345303 cites W2123329911 @default.
- W1893345303 cites W2124951925 @default.
- W1893345303 cites W2129820993 @default.
- W1893345303 cites W2130459043 @default.
- W1893345303 cites W2130880975 @default.
- W1893345303 cites W2135578925 @default.
- W1893345303 cites W2135783367 @default.
- W1893345303 cites W2136088258 @default.
- W1893345303 cites W2150756306 @default.