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• W1893492423 abstract "Immunoglobulin (Ig) genes are rearranged in pre-B cells. Pre-B cells that express Ig heavy (H) and light (L) chain genes whose V(D)J recombination results in a functional reading frame mature into B cells that exit the bone marrow. The V(D)J recombination process creates a large repertoire of different variable regions from a restricted pool of germline genes. Additional variablity arises during the process of somatic hypermutation in mature B cells proliferating in germinal centers of lymphoid organs (reviewed in French et al. 1989). B cells that have mutated to express high-affinity antibodies are selected and develop into plasma cells or memory cells. B cells with mutations that decrease the affinity of the expressed Igs or that prevent Ig expression die by apoptosis. The somatic point mutations are located within the variable region and their proximate upstream and downstream flanks, but not generally within the constant region." @default.
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• W1893492423 date "1998-01-01" @default.
• W1893492423 modified "2023-09-30" @default.
• W1893492423 title "Somatic Hypermutation of Immunoglobulin Genes is Linked to Transcription" @default.
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• W1893492423 doi "https://doi.org/10.1007/978-3-642-71984-4_2" @default.
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