FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1894037130> ?p ?o ?g. }

• W1894037130 endingPage "1462" @default.
• W1894037130 startingPage "1452" @default.
• W1894037130 abstract "Introduction The interaction between advanced glycation end-products (AGEs) and its receptors for AGEs (RAGEs) elicits oxidative stress and mediates the development of erectile dysfunction (ED). ALT-711, an AGE cross-link breaker, has the therapeutic potential for ED but has been less intensively investigated. Aim The aim of this study was to investigate the effects of an AGEs breaker 3-phenacyl-4,5-dimethylthiazolium chloride (ALT-711) plus insulin on erectile function in streptozocin (STZ)-induced type 1 diabetic rats. Methods Fifty 8-week-old Sprague-Dawley rats were randomly distributed into five groups: normal control (C), diabetic (D), insulin-treated diabetic (D + I), ALT-711-treated diabetic (D + ALT-711) and insulin plus ALT-711-treated diabetic (D + I + ALT-711) rats. Diabetes was induced by a single intraperitoneal injection of STZ. Eight weeks after induction of diabetes, ALT-711 was administered by intraperitoneal injection. Two to six units of intermediate-acting insulin were utilized to achieve normal levels of glycemic control. After treatment for 6 weeks, erectile function was determined via measurement of intracavernous pressures (ICPs) following electrostimulation of the cavernous nerve. The deposition of AGEs, expression of RAGEs, superoxide dismutase activity, and lipid peroxidation were measured. We also evaluated penile histological changes such as smooth muscle contents, endothelial cells contents, and apoptotic activity. Main Outcome Measures The main outcome measures were the ratio of ICP/mean arterial pressure (MAP), penile endothelial cells, smooth muscle cells, neuronal nitric oxide synthase, AGE and RAGE expression, malondialdehyde concentration, SOD activity, and apoptosis index. Results Diabetic rats demonstrated significantly reduced ICP/MAP ratio, penile endothelial cells, smooth muscles cells, increased AGEs and RAGE expression, and increased apoptosis. Insulin and ALT-711 monotherapy partially restored erectile function and histological changes. However, the combination therapy group showed erectile parameters and components similar to those in C. ALT-711-treated group demonstrated less deposition of AGEs and lower expression of RAGE than those in insulin-treated group. Conclusion These results suggest that although insulin can effectively control glycemic levels, it does not completely alter the pathological changes in erectile tissues. Better efficacy could be expected with tight glycemic control plus ALT-711, an AGEs cross-link breaker. The combination therapy might have the potential to eliminate metabolic memory by down-regulating the AGEs–RAGE oxidative stress axis. Wang L, Tian W, Uwais Z, Li G, Li H, Guan R, Gao Z, and Xin Z. AGE-breaker ALT-711 plus insulin could restore erectile function in streptozocin-induced type 1 diabetic rats. J Sex Med 2014;11:1452–1462." @default.
• W1894037130 created "2016-06-24" @default.
• W1894037130 creator A5017254585 @default.
• W1894037130 creator A5025351804 @default.
• W1894037130 creator A5045806343 @default.
• W1894037130 creator A5051298638 @default.
• W1894037130 creator A5053275663 @default.
• W1894037130 creator A5073408567 @default.
• W1894037130 creator A5079186859 @default.
• W1894037130 creator A5088330075 @default.
• W1894037130 date "2014-06-01" @default.
• W1894037130 modified "2023-10-10" @default.
• W1894037130 title "AGE-Breaker ALT-711 Plus Insulin Could Restore Erectile Function in Streptozocin-Induced Type 1 Diabetic Rats" @default.
• W1894037130 cites W1515803726 @default.
• W1894037130 cites W1526927233 @default.
• W1894037130 cites W1752045965 @default.
• W1894037130 cites W1832887128 @default.
• W1894037130 cites W1998961557 @default.
• W1894037130 cites W2008586394 @default.
• W1894037130 cites W2015426450 @default.
• W1894037130 cites W2017800180 @default.
• W1894037130 cites W2024709804 @default.
• W1894037130 cites W2027604422 @default.
• W1894037130 cites W2030315827 @default.
• W1894037130 cites W2047964022 @default.
• W1894037130 cites W2058550328 @default.
• W1894037130 cites W2069510249 @default.
• W1894037130 cites W2107516773 @default.
• W1894037130 cites W2110601215 @default.
• W1894037130 cites W2111787122 @default.
• W1894037130 cites W2121306209 @default.
• W1894037130 cites W2136262455 @default.
• W1894037130 cites W2144805711 @default.
• W1894037130 cites W2147587029 @default.
• W1894037130 cites W2152805847 @default.
• W1894037130 cites W2158666727 @default.
• W1894037130 cites W2162430779 @default.
• W1894037130 cites W2218378049 @default.
• W1894037130 doi "https://doi.org/10.1111/jsm.12533" @default.
• W1894037130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24766706" @default.
• W1894037130 hasPublicationYear "2014" @default.
• W1894037130 type Work @default.
• W1894037130 sameAs 1894037130 @default.
• W1894037130 citedByCount "24" @default.
• W1894037130 countsByYear W18940371302014 @default.
• W1894037130 countsByYear W18940371302015 @default.
• W1894037130 countsByYear W18940371302016 @default.
• W1894037130 countsByYear W18940371302017 @default.
• W1894037130 countsByYear W18940371302018 @default.
• W1894037130 countsByYear W18940371302019 @default.
• W1894037130 countsByYear W18940371302020 @default.
• W1894037130 countsByYear W18940371302021 @default.
• W1894037130 countsByYear W18940371302022 @default.
• W1894037130 crossrefType "journal-article" @default.
• W1894037130 hasAuthorship W1894037130A5017254585 @default.
• W1894037130 hasAuthorship W1894037130A5025351804 @default.
• W1894037130 hasAuthorship W1894037130A5045806343 @default.
• W1894037130 hasAuthorship W1894037130A5051298638 @default.
• W1894037130 hasAuthorship W1894037130A5053275663 @default.
• W1894037130 hasAuthorship W1894037130A5073408567 @default.
• W1894037130 hasAuthorship W1894037130A5079186859 @default.
• W1894037130 hasAuthorship W1894037130A5088330075 @default.
• W1894037130 hasConcept C126322002 @default.
• W1894037130 hasConcept C134018914 @default.
• W1894037130 hasConcept C2776151105 @default.
• W1894037130 hasConcept C2779280383 @default.
• W1894037130 hasConcept C2779306644 @default.
• W1894037130 hasConcept C2779929075 @default.
• W1894037130 hasConcept C2780159080 @default.
• W1894037130 hasConcept C2911120302 @default.
• W1894037130 hasConcept C555293320 @default.
• W1894037130 hasConcept C71924100 @default.
• W1894037130 hasConceptScore W1894037130C126322002 @default.
• W1894037130 hasConceptScore W1894037130C134018914 @default.
• W1894037130 hasConceptScore W1894037130C2776151105 @default.
• W1894037130 hasConceptScore W1894037130C2779280383 @default.
• W1894037130 hasConceptScore W1894037130C2779306644 @default.
• W1894037130 hasConceptScore W1894037130C2779929075 @default.
• W1894037130 hasConceptScore W1894037130C2780159080 @default.
• W1894037130 hasConceptScore W1894037130C2911120302 @default.
• W1894037130 hasConceptScore W1894037130C555293320 @default.
• W1894037130 hasConceptScore W1894037130C71924100 @default.
• W1894037130 hasIssue "6" @default.
• W1894037130 hasLocation W18940371301 @default.
• W1894037130 hasLocation W18940371302 @default.
• W1894037130 hasOpenAccess W1894037130 @default.
• W1894037130 hasPrimaryLocation W18940371301 @default.
• W1894037130 hasRelatedWork W2005372304 @default.
• W1894037130 hasRelatedWork W2356539028 @default.
• W1894037130 hasRelatedWork W2366253291 @default.
• W1894037130 hasRelatedWork W2368451778 @default.
• W1894037130 hasRelatedWork W2379548360 @default.
• W1894037130 hasRelatedWork W2399110484 @default.
• W1894037130 hasRelatedWork W2740358460 @default.
• W1894037130 hasRelatedWork W2950138714 @default.
• W1894037130 hasRelatedWork W3006406582 @default.
• W1894037130 hasRelatedWork W4285675073 @default.
• W1894037130 hasVolume "11" @default.

• next