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- W1894229905 abstract "OBJECTIVE OF THE EXPERIMENT The students will observe the three main events of limb development. They will observe first, how proximo-distal limb outgrowth is achieved; second, how chondrogenic differentiation contributes to the establishment of the future skeleton; and third, how limb shape is sculpted by apoptosis. The avian embryo is a good model for the study of these processes, as eggs are easy to obtain and manipulate, and the resulting phenotypes can be observed at different time points. By using the application of microspheres soaked in the different proteins, students will visualise how the proximo-distal axis is controlled during limb bud development. Students will also observe how the chondrogenic template, which will be substituted by osteogenic tissue, develops to form the different elements and joints of the limb. Lastly, students will use a technique for visualizing cell death that enables the assessment of both how cell death takes place during limb development and how this is correlated with the morphology of the limb bud in different species. The exercises are completed by studying the action of different secreted molecules involved in apoptosis and chondrogenesis." @default.
- W1894229905 created "2016-06-24" @default.
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- W1894229905 date "2005-03-24" @default.
- W1894229905 modified "2023-10-18" @default.
- W1894229905 title "Experimental manipulations during limb development in avian embryos" @default.
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- W1894229905 doi "https://doi.org/10.1017/cbo9780511546204.009" @default.
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