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• W1894267612 abstract "Peptides and polypeptides either fully or partially built of D-amino acids interest researchers because of their advantages over all L peptides and polypeptides. In exploiting these characteristics, one should realize that the resulting molecules are nonetheless not inert, but rather may induce a unique immune response, which is hardly cross-reactive with the L-enantiomer. Moreover, cross-reaction between the L- and the D-sequences is limited also at the T cell level, probably due to different sterical conformations of the MHC-antigen-T cell receptor complexes formed. Polypeptides built exclusively of D-amino acids lead to antibody formation only at a relatively low concentration, otherwise they provoke immunological paralysis. The specificity of the immune response toward peptides containing D-amino acid residues is exquisite, and often D-amino acids play a dominant role in defining the specificity. Polypeptides composed exclusively of D-amino acids are thymus-independent antigens. Nevertheless, it is possible to prepare against them highly specific T cell hybridomas. In future plans for synthetic vaccines against infectious or autoimmune diseases, the inclusion of D-amino acids may be an advantage in terms of both specificity and efficacy, the latter because of longer persistence in an undigested form because they resist enzymatic degradation." @default.
• W1894267612 created "2016-06-24" @default.
• W1894267612 creator A5016902113 @default.
• W1894267612 creator A5023962321 @default.
• W1894267612 date "1997-05-01" @default.
• W1894267612 modified "2023-10-16" @default.
• W1894267612 title "Different roles of D‐amino acids in immune phenomena" @default.
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• W1894267612 doi "https://doi.org/10.1096/fasebj.11.6.9194525" @default.
• W1894267612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9194525" @default.
• W1894267612 hasPublicationYear "1997" @default.
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