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• W1894311993 endingPage "353" @default.
• W1894311993 startingPage "341" @default.
• W1894311993 abstract "Neuronal microcircuits, small, localized signaling motifs involving two or more neurons, underlie signal processing and computation in the brain. Compartmentalized signaling within a neuron may enable it to participate in multiple, independent microcircuits. Each A17 amacrine cell in the mammalian retina contains within its dendrites hundreds of synaptic feedback microcircuits that operate independently to modulate feedforward signaling in the inner retina. Each of these microcircuits comprises a small (<1 μm) synaptic varicosity that typically receives one excitatory synapse from a presynaptic rod bipolar cell (RBC) and returns two reciprocal inhibitory synapses back onto the same RBC terminal. Feedback inhibition from the A17 sculpts the feedforward signal from the RBC to the AII, a critical component of the circuitry mediating night vision. Here, we show that the two inhibitory synapses from the A17 to the RBC express kinetically distinct populations of GABA receptors: rapidly activating GABA(A)Rs are enriched at one synapse while more slowly activating GABA(C)Rs are enriched at the other. Anatomical and electrophysiological data suggest that macromolecular complexes of voltage-gated (Cav) channels and Ca(2+)-activated K(+) channels help to regulate GABA release from A17 varicosities and limit GABA(C)R activation under certain conditions. Finally, we find that selective elimination of A17-mediated feedback inhibition reduces the signal to noise ratio of responses to dim flashes recorded in the feedforward pathway (i.e., the AII amacrine cell). We conclude that A17-mediated feedback inhibition improves the signal to noise ratio of RBC-AII transmission near visual threshold, thereby improving visual sensitivity at night." @default.
• W1894311993 created "2016-06-24" @default.
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• W1894311993 date "2015-07-01" @default.
• W1894311993 modified "2023-10-03" @default.
• W1894311993 title "Complex inhibitory microcircuitry regulates retinal signaling near visual threshold" @default.
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• W1894311993 doi "https://doi.org/10.1152/jn.00017.2015" @default.
• W1894311993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4507961" @default.
• W1894311993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25972578" @default.
• W1894311993 hasPublicationYear "2015" @default.
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