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• W1894316305 abstract "Objectives/Hypothesis In this study, we addressed the immunotherapeutic potential of human placental extract (HPE) in a murine allergic rhinitis (AR) model and explored its immunological mechanisms. Study Design In vivo study using an animal model. Methods HPE was administered to BALB/c mice before sensitization with allergen ( Dermatophagoides farinae [Derf]) (pre‐S group) or after allergen challenge (post‐C group). The groups were compared with Derf‐treated mice that received no HPE (Derf group) and phosphate buffered saline (PBS)‐treated mice (control). Allergic symptom scores, eosinophil counts, and serum Derf‐specific IgE levels were measured. mRNA expression levels of interferon (IFN)‐γ, T‐bet, interleukin (IL)‐4, GATA‐3, and Foxp3 in nasal mucosa were determined by real‐time polymerase chain reaction. IFN‐γ, T‐bet, IL‐4, and GATA‐3 were confirmed by Western blotting analysis. Spleen CD4 + CD25 + Foxp3 + T cells were detected using flow cytometry. Results Rubbing motions, serum Derf‐specific IgE, GATA‐3 mRNA levels, IL‐4 mRNA levels, and tissue eosinophil counts were decreased in both pre‐S and post‐C groups (all P < 0.05). Western blots showed decreased expression of GATA‐3 and IL‐4 in both pre‐S and post‐C groups as compared to the Derf group. An increased percentage of CD4 + CD25 + Foxp3 + T cells and an increased level of Foxp3 mRNA were found in pre‐S and post‐C groups as compared to those in the Derf group (all P < 0.05). Conclusion Both prophylactic and therapeutic treatments with HPE significantly reduced allergic inflammation in nasal mucosa and had the potential to induce regulatory T cells in a murine model of AR. Level of Evidence N/A. Laryngoscope 124:E399–E404, 2014" @default.
• W1894316305 created "2016-06-24" @default.
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• W1894316305 date "2014-06-03" @default.
• W1894316305 modified "2023-10-16" @default.
• W1894316305 title "Human placental extract reduces allergic inflammation in a murine allergic rhinitis model" @default.
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• W1894316305 doi "https://doi.org/10.1002/lary.24714" @default.
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