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- W189439181 abstract "We compared estimates of phenylalanine hydroxylation (Phe-OH), across a range of tyrosine intakes, determined using plasma and ApoB-100 phenylalanine and tyrosine enrichments, with a measurement of in vivo change in protein synthesis. Six, healthy, male subjects receiving 4.54 μmol.kg−1.h−1 of phenylalanine, were randomized to receive each of the 7 test tyrosine intakes (3, 4.5, 6.0, 7.5, 9.0, 10.5 and 12 mg.kg−1.d−1) for 3-d. Studies were conducted at each level using the tracers of L-[15N] phenylalanine and L-[3,3-2H2] tyrosine. Blood samples were collected at baseline and isotopic steady state. Repeated ANOVA using mixed model was performed to assess the effect of tyrosine intake on phenylalanine hydroxylation. Using ApoB-100 as the sampling site, estimates of phenylalanine hydroxylation were lower than those from plasma phenylalanine and tyrosine. Apob-100 enrichment followed a linear plateau pattern with a break point at a tyrosine intake of 6.8 mg.kg−1.d−1. We conclude that ApoB-100 is a more suitable method than plasma for estimating intracellular enrichment of amino acids in the liver. (CIHR supported). Table 1. Effect of Tyrosine intake on Phe-OH (μmol.kg−1.h−1) in plasma and ApoB-100 protein" @default.
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- W189439181 date "2007-04-01" @default.
- W189439181 modified "2023-09-26" @default.
- W189439181 title "Regulation of in vivo phenylalanine hydroxylation by dietary tyrosine using enrichment in Apo‐B100" @default.
- W189439181 doi "https://doi.org/10.1096/fasebj.21.5.a332" @default.
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