Matches in SemOpenAlex for { <https://semopenalex.org/work/W1894536429> ?p ?o ?g. }
- W1894536429 endingPage "3837" @default.
- W1894536429 startingPage "3822" @default.
- W1894536429 abstract "The liver, the largest organ in the human body, is a multi-functional organ with diverse metabolic activities that plays a critical role in maintaining the body and sustaining life. Although the liver has excellent regenerative and recuperative properties, damages caused by chronic liver diseases or viral infection may lead to permanent loss of liver functions. Studies of liver disease mechanism have focused on drug screening and liver tissue engineering techniques, including strategies based on in vitro models. However, conventional liver models are plagued by a number of limitations, which have motivated the development of 'liver-on-a-chip' and microplatform-based bioreactors that can provide well-defined microenvironments. Microtechnology is a promising tool for liver tissue engineering and liver system development, as it can mimic the complex in vivo microenvironment and microlevel ultrastructure, by using a small number of human cells under two-dimensional (2D) and three-dimensional (3D) culture conditions. These systems provided by microtechnology allow improved liver-specific functions and can be expanded to encompass diverse 3D culture methods, which are critical for the maintenance of liver functions and recapitulation of the features of the native liver. In this review, we provide an overview of microtechnologies that have been used for liver studies, describe biomimetic technologies for constructing microscale 2D and 3D liver models as well as liver-on-a-chip systems and microscale bioreactors, and introduce applications of liver microtechnology and future trends in the field." @default.
- W1894536429 created "2016-06-24" @default.
- W1894536429 creator A5011148386 @default.
- W1894536429 creator A5019886336 @default.
- W1894536429 creator A5040025378 @default.
- W1894536429 creator A5087996909 @default.
- W1894536429 date "2015-01-01" @default.
- W1894536429 modified "2023-10-14" @default.
- W1894536429 title "3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip" @default.
- W1894536429 cites W1848527143 @default.
- W1894536429 cites W1853057935 @default.
- W1894536429 cites W1927390986 @default.
- W1894536429 cites W1965341391 @default.
- W1894536429 cites W1966959914 @default.
- W1894536429 cites W1968267859 @default.
- W1894536429 cites W1970857673 @default.
- W1894536429 cites W1972086788 @default.
- W1894536429 cites W1972264416 @default.
- W1894536429 cites W1974268523 @default.
- W1894536429 cites W1977761310 @default.
- W1894536429 cites W1978400497 @default.
- W1894536429 cites W1979665070 @default.
- W1894536429 cites W1980080300 @default.
- W1894536429 cites W1980998826 @default.
- W1894536429 cites W1981684516 @default.
- W1894536429 cites W1981810736 @default.
- W1894536429 cites W1986732540 @default.
- W1894536429 cites W1987133692 @default.
- W1894536429 cites W1989316730 @default.
- W1894536429 cites W1991273988 @default.
- W1894536429 cites W1993194931 @default.
- W1894536429 cites W1994258387 @default.
- W1894536429 cites W1995710831 @default.
- W1894536429 cites W1996442444 @default.
- W1894536429 cites W1996513265 @default.
- W1894536429 cites W2000151960 @default.
- W1894536429 cites W2000984827 @default.
- W1894536429 cites W2002155653 @default.
- W1894536429 cites W2003142831 @default.
- W1894536429 cites W2003728131 @default.
- W1894536429 cites W2003986773 @default.
- W1894536429 cites W2004875910 @default.
- W1894536429 cites W2005068387 @default.
- W1894536429 cites W2006914719 @default.
- W1894536429 cites W2007725471 @default.
- W1894536429 cites W2008311131 @default.
- W1894536429 cites W2008448204 @default.
- W1894536429 cites W2009563491 @default.
- W1894536429 cites W2010326072 @default.
- W1894536429 cites W2012867417 @default.
- W1894536429 cites W2014134791 @default.
- W1894536429 cites W2017666539 @default.
- W1894536429 cites W2017854405 @default.
- W1894536429 cites W2018683165 @default.
- W1894536429 cites W2019350759 @default.
- W1894536429 cites W2021592954 @default.
- W1894536429 cites W2021996296 @default.
- W1894536429 cites W2023253236 @default.
- W1894536429 cites W2023296392 @default.
- W1894536429 cites W2031334002 @default.
- W1894536429 cites W2032871999 @default.
- W1894536429 cites W2033712039 @default.
- W1894536429 cites W2038535524 @default.
- W1894536429 cites W2041356700 @default.
- W1894536429 cites W2045055151 @default.
- W1894536429 cites W2045167226 @default.
- W1894536429 cites W2045911112 @default.
- W1894536429 cites W2050451559 @default.
- W1894536429 cites W2050827942 @default.
- W1894536429 cites W2051054662 @default.
- W1894536429 cites W2052052497 @default.
- W1894536429 cites W2053367823 @default.
- W1894536429 cites W2055037957 @default.
- W1894536429 cites W2055750908 @default.
- W1894536429 cites W2057692465 @default.
- W1894536429 cites W2057793946 @default.
- W1894536429 cites W2057912627 @default.
- W1894536429 cites W2058221324 @default.
- W1894536429 cites W2058794699 @default.
- W1894536429 cites W2060475101 @default.
- W1894536429 cites W2061101624 @default.
- W1894536429 cites W2063053827 @default.
- W1894536429 cites W2065657273 @default.
- W1894536429 cites W2065888295 @default.
- W1894536429 cites W2066482021 @default.
- W1894536429 cites W2067189227 @default.
- W1894536429 cites W2068201611 @default.
- W1894536429 cites W2071628173 @default.
- W1894536429 cites W2072539987 @default.
- W1894536429 cites W2072589468 @default.
- W1894536429 cites W2072830086 @default.
- W1894536429 cites W2073329698 @default.
- W1894536429 cites W2076922024 @default.
- W1894536429 cites W2079165554 @default.
- W1894536429 cites W2079277029 @default.
- W1894536429 cites W2079582212 @default.
- W1894536429 cites W2080936427 @default.
- W1894536429 cites W2083799705 @default.