FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1894630692> ?p ?o ?g. }

• W1894630692 endingPage "999" @default.
• W1894630692 startingPage "987" @default.
• W1894630692 abstract "Summary Deoxynivalenol ( DON ), a trichothecene mycotoxin produced by F usarium graminearum , is harmful to humans and animals. Because different nitrogen sources are known to have opposite effects on DON production, in this study, we characterized the regulatory mechanisms of the AREA transcription factor in trichothecene biosynthesis. The Δ are A mutant showed significantly reduced vegetative growth and DON production in cultures inoculated with hyphae. Suppression of TRI gene expression and DON production by ammonium were diminished in the Δ are A mutant. The deletion of AREA also affected the stimulatory effects of arginine on DON biosynthesis. The AreA ‐green fluorescent protein ( GFP ) fusion complemented the Δ are A mutant, and its localization to the nucleus was enhanced under nitrogen starvation conditions. Site‐directed mutagenesis showed that the conserved predicted protein kinase A ( PKA ) phosphorylation site S874 was important for AreA function, indicating that AreA may be a downstream target of the cyclic adenosine monophosphate ( cAMP )‐ PKA pathway, which is known to regulate DON production. We also showed that AreA interacted with T ri10 in co‐immunoprecipitation assays. The interaction of AreA with T ri10 is probably related to its role in the regulation of TRI gene expression. Interestingly, the Δ are A mutant showed significantly reduced PKA activity and expression of all three predicted ammonium permease ( MEP ) genes, in particular MEP1 , under low ammonium conditions. Taken together, our results show that AREA is involved in the regulation of DON production by ammonium suppression and the cAMP ‐ PKA pathway. The AreA transcription factor may interact with T ri10 and control the expression and up‐regulation of MEP genes." @default.
• W1894630692 created "2016-06-24" @default.
• W1894630692 creator A5022073926 @default.
• W1894630692 creator A5026260090 @default.
• W1894630692 creator A5053044736 @default.
• W1894630692 creator A5079644014 @default.
• W1894630692 creator A5082176762 @default.
• W1894630692 date "2015-05-04" @default.
• W1894630692 modified "2023-10-12" @default.
• W1894630692 title "The AreA transcription factor mediates the regulation of deoxynivalenol (DON) synthesis by ammonium and cyclic adenosine monophosphate (cAMP) signalling in<i>Fusarium graminearum</i>" @default.
• W1894630692 cites W131839835 @default.
• W1894630692 cites W1530090284 @default.
• W1894630692 cites W1562268234 @default.
• W1894630692 cites W1614347411 @default.
• W1894630692 cites W165134962 @default.
• W1894630692 cites W1767202943 @default.
• W1894630692 cites W1935093073 @default.
• W1894630692 cites W1935948820 @default.
• W1894630692 cites W1938883586 @default.
• W1894630692 cites W1963871367 @default.
• W1894630692 cites W1966594946 @default.
• W1894630692 cites W1982968657 @default.
• W1894630692 cites W1994247089 @default.
• W1894630692 cites W1995398216 @default.
• W1894630692 cites W2000395580 @default.
• W1894630692 cites W2000843859 @default.
• W1894630692 cites W2006904944 @default.
• W1894630692 cites W2015218321 @default.
• W1894630692 cites W2016077253 @default.
• W1894630692 cites W2018216894 @default.
• W1894630692 cites W2019359700 @default.
• W1894630692 cites W2019738535 @default.
• W1894630692 cites W2020990240 @default.
• W1894630692 cites W2025209341 @default.
• W1894630692 cites W2035455556 @default.
• W1894630692 cites W2035757135 @default.
• W1894630692 cites W2036354503 @default.
• W1894630692 cites W2042985138 @default.
• W1894630692 cites W2045776897 @default.
• W1894630692 cites W2049922525 @default.
• W1894630692 cites W2064327030 @default.
• W1894630692 cites W2067699530 @default.
• W1894630692 cites W2071118001 @default.
• W1894630692 cites W2081360339 @default.
• W1894630692 cites W2086088421 @default.
• W1894630692 cites W2093296829 @default.
• W1894630692 cites W2093519925 @default.
• W1894630692 cites W2093784855 @default.
• W1894630692 cites W2097458745 @default.
• W1894630692 cites W2100605571 @default.
• W1894630692 cites W2106450047 @default.
• W1894630692 cites W2107277218 @default.
• W1894630692 cites W2107414020 @default.
• W1894630692 cites W2108277015 @default.
• W1894630692 cites W2109174079 @default.
• W1894630692 cites W2113353075 @default.
• W1894630692 cites W2114118401 @default.
• W1894630692 cites W2114853315 @default.
• W1894630692 cites W2117944186 @default.
• W1894630692 cites W2118260141 @default.
• W1894630692 cites W2124603595 @default.
• W1894630692 cites W2125089823 @default.
• W1894630692 cites W2127270784 @default.
• W1894630692 cites W2127464671 @default.
• W1894630692 cites W2139838921 @default.
• W1894630692 cites W2140248780 @default.
• W1894630692 cites W2140602911 @default.
• W1894630692 cites W2141876161 @default.
• W1894630692 cites W2146112868 @default.
• W1894630692 cites W2152187233 @default.
• W1894630692 cites W2152701278 @default.
• W1894630692 cites W2152725474 @default.
• W1894630692 cites W2152745547 @default.
• W1894630692 cites W2153861569 @default.
• W1894630692 cites W2154689564 @default.
• W1894630692 cites W2157209798 @default.
• W1894630692 cites W2158540235 @default.
• W1894630692 cites W2162294196 @default.
• W1894630692 cites W2166193187 @default.
• W1894630692 cites W2168120526 @default.
• W1894630692 cites W2192080449 @default.
• W1894630692 cites W2412666212 @default.
• W1894630692 cites W4249110695 @default.
• W1894630692 doi "https://doi.org/10.1111/mpp.12254" @default.
• W1894630692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6638501" @default.
• W1894630692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25781642" @default.
• W1894630692 hasPublicationYear "2015" @default.
• W1894630692 type Work @default.
• W1894630692 sameAs 1894630692 @default.
• W1894630692 citedByCount "56" @default.
• W1894630692 countsByYear W18946306922015 @default.
• W1894630692 countsByYear W18946306922016 @default.
• W1894630692 countsByYear W18946306922017 @default.
• W1894630692 countsByYear W18946306922018 @default.
• W1894630692 countsByYear W18946306922019 @default.
• W1894630692 countsByYear W18946306922020 @default.
• W1894630692 countsByYear W18946306922021 @default.
• W1894630692 countsByYear W18946306922022 @default.

• next