FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1894682364> ?p ?o ?g. }

• W1894682364 endingPage "e0004130" @default.
• W1894682364 startingPage "e0004130" @default.
• W1894682364 abstract "Monkeypox is a zoonosis clinically similar to smallpox in humans. Recent evidence has shown a potential risk of increased incidence in central Africa. Despite attempts to isolate the virus from wild rodents and other small mammals, no reservoir host has been identified. In 2003, Monkeypox virus (MPXV) was accidentally introduced into the U.S. via the pet trade and was associated with the Gambian pouched rat (Cricetomys gambianus). Therefore, we investigated the potential reservoir competence of the Gambian pouched rat for MPXV by utilizing a combination of in vivo and in vitro methods. We inoculated three animals by the intradermal route and three animals by the intranasal route, with one mock-infected control for each route. Bioluminescent imaging (BLI) was used to track replicating virus in infected animals and virological assays (e.g. real time PCR, cell culture) were used to determine viral load in blood, urine, ocular, nasal, oral, and rectal swabs. Intradermal inoculation resulted in clinical signs of monkeypox infection in two of three animals. One severely ill animal was euthanized and the other affected animal recovered. In contrast, intranasal inoculation resulted in subclinical infection in all three animals. All animals, regardless of apparent or inapparent infection, shed virus in oral and nasal secretions. Additionally, BLI identified viral replication in the skin without grossly visible lesions. These results suggest that Gambian pouched rats may play an important role in transmission of the virus to humans, as they are hunted for consumption and it is possible for MPXV-infected pouched rats to shed infectious virus without displaying overt clinical signs." @default.
• W1894682364 created "2016-06-24" @default.
• W1894682364 creator A5000928686 @default.
• W1894682364 creator A5007785617 @default.
• W1894682364 creator A5010964128 @default.
• W1894682364 creator A5012453301 @default.
• W1894682364 creator A5035068461 @default.
• W1894682364 creator A5048952101 @default.
• W1894682364 creator A5053162775 @default.
• W1894682364 creator A5063845759 @default.
• W1894682364 creator A5077092566 @default.
• W1894682364 creator A5080119127 @default.
• W1894682364 date "2015-10-30" @default.
• W1894682364 modified "2023-10-16" @default.
• W1894682364 title "Further Assessment of Monkeypox Virus Infection in Gambian Pouched Rats (Cricetomys gambianus) Using In Vivo Bioluminescent Imaging" @default.
• W1894682364 cites W1963600159 @default.
• W1894682364 cites W1973795375 @default.
• W1894682364 cites W1978369229 @default.
• W1894682364 cites W1982539402 @default.
• W1894682364 cites W1984679538 @default.
• W1894682364 cites W1994357942 @default.
• W1894682364 cites W1994622044 @default.
• W1894682364 cites W1996213609 @default.
• W1894682364 cites W2004384520 @default.
• W1894682364 cites W2012788756 @default.
• W1894682364 cites W2030680260 @default.
• W1894682364 cites W2031116739 @default.
• W1894682364 cites W2034512078 @default.
• W1894682364 cites W2037326132 @default.
• W1894682364 cites W2042870665 @default.
• W1894682364 cites W2043441417 @default.
• W1894682364 cites W2048325875 @default.
• W1894682364 cites W2054733388 @default.
• W1894682364 cites W2062389463 @default.
• W1894682364 cites W2065293827 @default.
• W1894682364 cites W2068395730 @default.
• W1894682364 cites W2075170254 @default.
• W1894682364 cites W2083067586 @default.
• W1894682364 cites W2097202840 @default.
• W1894682364 cites W2121101085 @default.
• W1894682364 cites W2122669011 @default.
• W1894682364 cites W2145663614 @default.
• W1894682364 cites W2147358970 @default.
• W1894682364 cites W2154891836 @default.
• W1894682364 cites W2162797950 @default.
• W1894682364 cites W2166801660 @default.
• W1894682364 cites W2168127024 @default.
• W1894682364 cites W2169163327 @default.
• W1894682364 cites W2172904162 @default.
• W1894682364 cites W2398748576 @default.
• W1894682364 cites W2406429910 @default.
• W1894682364 cites W4247460913 @default.
• W1894682364 cites W4296249910 @default.
• W1894682364 doi "https://doi.org/10.1371/journal.pntd.0004130" @default.
• W1894682364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4627722" @default.
• W1894682364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26517839" @default.
• W1894682364 hasPublicationYear "2015" @default.
• W1894682364 type Work @default.
• W1894682364 sameAs 1894682364 @default.
• W1894682364 citedByCount "47" @default.
• W1894682364 countsByYear W18946823642017 @default.
• W1894682364 countsByYear W18946823642018 @default.
• W1894682364 countsByYear W18946823642019 @default.
• W1894682364 countsByYear W18946823642020 @default.
• W1894682364 countsByYear W18946823642022 @default.
• W1894682364 countsByYear W18946823642023 @default.
• W1894682364 crossrefType "journal-article" @default.
• W1894682364 hasAuthorship W1894682364A5000928686 @default.
• W1894682364 hasAuthorship W1894682364A5007785617 @default.
• W1894682364 hasAuthorship W1894682364A5010964128 @default.
• W1894682364 hasAuthorship W1894682364A5012453301 @default.
• W1894682364 hasAuthorship W1894682364A5035068461 @default.
• W1894682364 hasAuthorship W1894682364A5048952101 @default.
• W1894682364 hasAuthorship W1894682364A5053162775 @default.
• W1894682364 hasAuthorship W1894682364A5063845759 @default.
• W1894682364 hasAuthorship W1894682364A5077092566 @default.
• W1894682364 hasAuthorship W1894682364A5080119127 @default.
• W1894682364 hasBestOaLocation W18946823641 @default.
• W1894682364 hasConcept C104317684 @default.
• W1894682364 hasConcept C113280763 @default.
• W1894682364 hasConcept C12914427 @default.
• W1894682364 hasConcept C140704245 @default.
• W1894682364 hasConcept C159047783 @default.
• W1894682364 hasConcept C203014093 @default.
• W1894682364 hasConcept C2522874641 @default.
• W1894682364 hasConcept C2778011067 @default.
• W1894682364 hasConcept C2781356689 @default.
• W1894682364 hasConcept C40767141 @default.
• W1894682364 hasConcept C55493867 @default.
• W1894682364 hasConcept C86803240 @default.
• W1894682364 hasConceptScore W1894682364C104317684 @default.
• W1894682364 hasConceptScore W1894682364C113280763 @default.
• W1894682364 hasConceptScore W1894682364C12914427 @default.
• W1894682364 hasConceptScore W1894682364C140704245 @default.
• W1894682364 hasConceptScore W1894682364C159047783 @default.
• W1894682364 hasConceptScore W1894682364C203014093 @default.
• W1894682364 hasConceptScore W1894682364C2522874641 @default.
• W1894682364 hasConceptScore W1894682364C2778011067 @default.

• next