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• W1894781685 abstract "Objective To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC. Materials and Methods immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age = 63.6 years old; 20 women, mean age = 63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan–Meier method. Results FABP7 mRNA expression was more frequent in men ( P = 0.07) while BRN2 protein expression was significantly more frequent in women ( P = 0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (–) and BRN2 (+) groups had a worse prognosis both in mRNA level ( P = 0.038) and protein level ( P = 0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels. Conclusions Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC." @default.
• W1894781685 created "2016-06-24" @default.
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• W1894781685 date "2014-01-01" @default.
• W1894781685 modified "2023-09-27" @default.
• W1894781685 title "Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival" @default.
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• W1894781685 doi "https://doi.org/10.4137/cmo.s13684" @default.
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