Matches in SemOpenAlex for { <https://semopenalex.org/work/W1894938963> ?p ?o ?g. }
- W1894938963 endingPage "374" @default.
- W1894938963 startingPage "368" @default.
- W1894938963 abstract "Despite the known anticancer potential of resveratrol, its clinical applications are often hindered by physicochemical limitations such as poor solubility and stability. The encapsulation of resveratrol in formulations such as polymeric nanoparticles and liposomes has shown limited success. This study aimed to develop and optimize a novel drug carrier by co-encapsulating pristine resveratrol alongside cyclodextrin-resveratrol inclusion complexes in the lipophilic and hydrophilic compartments of liposomes, respectively by using a novel dual carrier approach. The particle size, polydispersity index and zeta potential of the final formulation were 131±1.30nm, 0.089±0.005 and -2.64±0.51mV, respectively. Compared to free resveratrol and conventional liposomal formulations with drug release profile of 40-60%, our novel nanoformulations showed complete (100%) drug release in 24h. The formulation was stable for 14days at 4°C. We also studied the in vitro cytotoxicity of resveratrol encapsulated liposomes in HT-29 colon cancer cell lines. The cytotoxicity profile of our liposomes was observed to be dose dependent and enhanced in comparison to free resveratrol (in DMSO). Our study demonstrates that co-encapsulation of pristine resveratrol along with its cyclodextrin complex in liposomal formulations is a plausible option for the enhanced delivery of the hydrophobic chemotherapeutic agent." @default.
- W1894938963 created "2016-06-24" @default.
- W1894938963 creator A5005283924 @default.
- W1894938963 creator A5027627095 @default.
- W1894938963 creator A5033502189 @default.
- W1894938963 creator A5040640303 @default.
- W1894938963 creator A5055486123 @default.
- W1894938963 creator A5078179230 @default.
- W1894938963 date "2016-01-01" @default.
- W1894938963 modified "2023-10-16" @default.
- W1894938963 title "Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach" @default.
- W1894938963 cites W1965444922 @default.
- W1894938963 cites W1966155066 @default.
- W1894938963 cites W1968199192 @default.
- W1894938963 cites W1969688942 @default.
- W1894938963 cites W1972586809 @default.
- W1894938963 cites W1976301691 @default.
- W1894938963 cites W1979175922 @default.
- W1894938963 cites W1985282426 @default.
- W1894938963 cites W1985858988 @default.
- W1894938963 cites W1996312920 @default.
- W1894938963 cites W2000108350 @default.
- W1894938963 cites W2015142587 @default.
- W1894938963 cites W2015408159 @default.
- W1894938963 cites W2016873771 @default.
- W1894938963 cites W2018468627 @default.
- W1894938963 cites W2027091780 @default.
- W1894938963 cites W2031570851 @default.
- W1894938963 cites W2037609941 @default.
- W1894938963 cites W2038100377 @default.
- W1894938963 cites W2042253399 @default.
- W1894938963 cites W2047592082 @default.
- W1894938963 cites W2047817628 @default.
- W1894938963 cites W2053030235 @default.
- W1894938963 cites W2054750511 @default.
- W1894938963 cites W2062219793 @default.
- W1894938963 cites W2066911530 @default.
- W1894938963 cites W2070513847 @default.
- W1894938963 cites W2073610140 @default.
- W1894938963 cites W2084662944 @default.
- W1894938963 cites W2086156875 @default.
- W1894938963 cites W2088336598 @default.
- W1894938963 cites W2090548281 @default.
- W1894938963 cites W2093094256 @default.
- W1894938963 cites W2110812103 @default.
- W1894938963 cites W2115400321 @default.
- W1894938963 cites W2119873087 @default.
- W1894938963 cites W2121539532 @default.
- W1894938963 cites W2125049757 @default.
- W1894938963 cites W2127256052 @default.
- W1894938963 cites W2131474316 @default.
- W1894938963 cites W2139358033 @default.
- W1894938963 cites W2156849286 @default.
- W1894938963 cites W2166566484 @default.
- W1894938963 cites W2317059039 @default.
- W1894938963 cites W2325732769 @default.
- W1894938963 doi "https://doi.org/10.1016/j.jcis.2015.10.022" @default.
- W1894938963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26479200" @default.
- W1894938963 hasPublicationYear "2016" @default.
- W1894938963 type Work @default.
- W1894938963 sameAs 1894938963 @default.
- W1894938963 citedByCount "86" @default.
- W1894938963 countsByYear W18949389632016 @default.
- W1894938963 countsByYear W18949389632017 @default.
- W1894938963 countsByYear W18949389632018 @default.
- W1894938963 countsByYear W18949389632019 @default.
- W1894938963 countsByYear W18949389632020 @default.
- W1894938963 countsByYear W18949389632021 @default.
- W1894938963 countsByYear W18949389632022 @default.
- W1894938963 countsByYear W18949389632023 @default.
- W1894938963 crossrefType "journal-article" @default.
- W1894938963 hasAuthorship W1894938963A5005283924 @default.
- W1894938963 hasAuthorship W1894938963A5027627095 @default.
- W1894938963 hasAuthorship W1894938963A5033502189 @default.
- W1894938963 hasAuthorship W1894938963A5040640303 @default.
- W1894938963 hasAuthorship W1894938963A5055486123 @default.
- W1894938963 hasAuthorship W1894938963A5078179230 @default.
- W1894938963 hasConcept C109316439 @default.
- W1894938963 hasConcept C11432220 @default.
- W1894938963 hasConcept C13245373 @default.
- W1894938963 hasConcept C155672457 @default.
- W1894938963 hasConcept C171250308 @default.
- W1894938963 hasConcept C178790620 @default.
- W1894938963 hasConcept C185154212 @default.
- W1894938963 hasConcept C185592680 @default.
- W1894938963 hasConcept C192562407 @default.
- W1894938963 hasConcept C202751555 @default.
- W1894938963 hasConcept C21951064 @default.
- W1894938963 hasConcept C2776816829 @default.
- W1894938963 hasConcept C2779433975 @default.
- W1894938963 hasConcept C2779820397 @default.
- W1894938963 hasConcept C43617362 @default.
- W1894938963 hasConcept C55493867 @default.
- W1894938963 hasConcept C71924100 @default.
- W1894938963 hasConcept C86181022 @default.
- W1894938963 hasConcept C98274493 @default.
- W1894938963 hasConceptScore W1894938963C109316439 @default.
- W1894938963 hasConceptScore W1894938963C11432220 @default.